Duodenal Involvement is an Independent Prognostic Factor for Patients with Surgically Resected Pancreatic Ductal Adenocarcinoma

2017 ◽  
Vol 24 (8) ◽  
pp. 2379-2386 ◽  
Author(s):  
Marco Dal Molin ◽  
Amanda L. Blackford ◽  
Abdulrehman Siddiqui ◽  
Aaron Brant ◽  
Christy Cho ◽  
...  



Pancreatology ◽  
2020 ◽  
Vol 20 (6) ◽  
pp. 1155-1163
Author(s):  
Yoshihiko Fukukura ◽  
Yuichi Kumagae ◽  
Ryutaro Higashi ◽  
Hiroto Hakamada ◽  
Hiroaki Nagano ◽  
...  


2018 ◽  
Vol 15 (4) ◽  
pp. 321-327 ◽  
Author(s):  
PETR KARASEK ◽  
NATALIA GABLO ◽  
JAN HLAVSA ◽  
IGOR KISS ◽  
PETRA VYCHYTILOVA-FALTEJSKOVA ◽  
...  


PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152523 ◽  
Author(s):  
Daisuke Sato ◽  
Takahiro Tsuchikawa ◽  
Tomoko Mitsuhashi ◽  
Yutaka Hatanaka ◽  
Katsuji Marukawa ◽  
...  


Pancreatology ◽  
2014 ◽  
Vol 14 (5) ◽  
pp. 385-390 ◽  
Author(s):  
Jiao Li ◽  
Dejun Liu ◽  
Rong Hua ◽  
Junfeng Zhang ◽  
Wei Liu ◽  
...  


2019 ◽  
Vol 18 ◽  
pp. 153303381882431 ◽  
Author(s):  
Yan Chen ◽  
Huiyun Zhu ◽  
Yuqiong Wang ◽  
Yingxiao Song ◽  
Pingping Zhang ◽  
...  

The role of microRNA-132 in human pancreatic ductal adenocarcinomas is still ambiguous. We explored the association between microRNA-132 and pancreatic ductal adenocarcinoma prognosis. The expression of microRNA-132 in 50 pancreatic ductal adenocarcinoma tissue samples and pancreatic ductal adenocarcinoma cell lines was examined, and the association between its expression and pancreatic ductal adenocarcinoma prognosis was assessed. Functional analysis and factors downstream of microRNA-132 were investigated. Kaplan-Meier survival curves showed that high expression of microRNA-132 was a significant prognostic factor for 1-year survival of patients with pancreatic ductal adenocarcinoma ( P = .028). Multivariate analysis for overall survival indicated that high expression of microRNA-132 was an independent prognostic factor for patients with pancreatic ductal adenocarcinoma ( P = .044). Low expression of microRNA-132 was associated with poor prognosis in pancreatic ductal adenocarcinoma. Ectopic expression of microRNA-132 significantly inhibited proliferation and promoted apoptosis of 2 pancreatic ductal adenocarcinoma cell lines. Bioinformatic analysis revealed that microRNA-132 may exert its effects on pancreatic ductal adenocarcinoma through downregulating mitogen-activated protein kinase 3 and nuclear transcription factor Y subunit α. The results of this study further our understanding of the relationship between microRNA-132 and pancreatic ductal adenocarcinoma by showing that microRNA-132 might inhibit the progression of pancreatic ductal adenocarcinoma by regulating mitogen-activated protein kinase and nuclear transcription factor Y subunit alpha.



2019 ◽  
Vol 476 (4) ◽  
pp. 561-568 ◽  
Author(s):  
Ekaterina Petrova ◽  
Verena Zielinski ◽  
Louisa Bolm ◽  
Cleopatra Schreiber ◽  
Juliana Knief ◽  
...  






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