scholarly journals Chemoimmunotherapeutic Approach to Prolonged Survival Time in Combination with Immunization and Glutamic Acid Derivatives with Antitumor Activity in Tumor-Bearing Mice

2007 ◽  
Vol 30 (12) ◽  
pp. 2334-2339 ◽  
Author(s):  
Soma Samanta ◽  
SK. Mahasin Alam ◽  
Soumya Basu ◽  
Tapas Maji ◽  
Dilip Kumar Roy ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Glutamic Acid ◽  
Survival Time ◽  
Prolonged Survival ◽  
Tumor Bearing ◽  
Glutamic Acid Derivatives

Nano-rods of doxorubicin with poly(l-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment

2016 ◽  
Vol 4 (45) ◽  
pp. 7283-7292 ◽  
Author(s):  
Saina Yang ◽  
Feiyan Zhu ◽  
Qian Wang ◽  
Fuxin Liang ◽  
Xiaozhong Qu ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Cancer Treatment ◽  
Survival Time ◽  
Release Profile ◽  
Intratumoral Administration ◽  
Tumor Bearing ◽  
Carrier Free ◽  
Nano Rods

Nano-rods of doxorubicin (DOX) were prepared by co-assembly with poly(l-glutamic acid) (PGA) and demonstrated a desired release profile for intratumoral administration that significantly prolonged the survival time of tumor-bearing mice.

On the Manner of Cyclization of N-Acylated Aspartic and Glutamic Acid Derivatives

2011 ◽  
Vol 17 (2) ◽  
pp. 93-100
Author(s):  
Paweł Zajdel ◽  
Christine Enjalbal ◽  
Marek Żylewski ◽  
Gilles Subra
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Derivatives

Antitumor activity of selective hyperthermia in tumor-bearing rats using thermosensitive magnetoliposomes as a new hyperthermic material

Drug Delivery ◽  
1997 ◽  
Vol 4 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Yoh Masuko ◽  
Kenji Tazawa ◽  
Hitoshi Sato ◽  
Ekapop Viroonchatapan ◽  
Shigeru Takemori ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Bearing

Ternary chromium(III)-nucleotide-amino acid complexes III. L-Glutamic acid derivatives

1989 ◽  
Vol 165 (1) ◽  
pp. 131-137 ◽  
Author(s):  
M. Vicens ◽  
J.J. Fiol ◽  
A. Terron ◽  
V. Moreno
Keyword(s):  
Amino Acid ◽  
Glutamic Acid ◽  
Amino Acid Complexes ◽  
Glutamic Acid Derivatives

scholarly journals A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL: Pharmacokinetics, Biodistribution, andIn VivoAntitumor Efficacy and Safety

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Wang ◽  
Ke-Chun Wu ◽  
Bing-Xiang Zhao ◽  
Xin Zhao ◽  
Xin Wang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Therapeutic Efficacy ◽  
Antitumor Efficacy ◽  
Allergic Reactions ◽  
Cremophor El ◽  
Efficacy And Safety ◽  
Tumor Bearing ◽  
Allergic Effect ◽  
Injection Product

The purpose of this study was to prepare a novel paclitaxel (PTX) microemulsion containing a reduced amount of Cremophor EL (CrEL) which had similar pharmacokinetics and antitumor efficacy as the commercially available PTX injection, but a significantly reduced allergic effect due to the CrEL. The pharmacokinetics, biodistribution,in vivoantitumor activity and safety of PTX microemulsion was evaluated. The results of pharmacokinetic and distribution properties of PTX in the microemulsion were similar to those of the PTX injection. The antitumor efficacy of the PTX microemulsion in OVCRA-3 and A 549 tumor-bearing animals was similar to that of PTX injection. The PTX microemulsion did not cause haemolysis, erythrocyte agglutination or simulative reaction. The incidence and degree of allergic reactions exhibited by the PTX microemulsion group, with or without premedication, were significantly lower than those in the PTX injection group (P<.01). In conclusion, the PTX microemulsion had similar pharmacokinetics and anti-tumor efficacy to the PTX injection, but a significantly reduced allergic effect due to CrEL, indicating that the PTX microemulsion overcomes the disadvantages of the conventional PTX injection and is one way of avoiding the limitations of current injection product while providing suitable therapeutic efficacy.

Solid-phase synthesis of Nα-benzyl-Nα-cinnamyl lysine and glutamic acid derivatives

2000 ◽  
Vol 41 (27) ◽  
pp. 5187-5191 ◽  
Author(s):  
Peter J Connolly ◽  
Kimberly N Beers ◽  
Steven K Wetter ◽  
William V Murray
Keyword(s):  
Glutamic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Glutamic Acid Derivatives

scholarly journals Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 2337-2348 ◽  
Author(s):  
Kazuo Azuma ◽  
Toshitsugu Ishihara ◽  
Hiroyuki Nakamoto ◽  
Takao Amaha ◽  
Tomohiro Osaki ◽  
...  
Keyword(s):  
Mouse Model ◽  
Oral Administration ◽  
Tumor Growth ◽  
Survival Time ◽  
Tumor Bearing Mouse ◽  
Growth And Survival ◽  
Tumor Bearing ◽  
Cladosiphon Okamuranus

NMR and Molecular Dynamics Study of the Binding Mode of Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives: Novel MurD Ligase Inhibitors

2009 ◽  
Vol 52 (9) ◽  
pp. 2899-2908 ◽  
Author(s):  
Mihael Simčič ◽  
Milan Hodošček ◽  
Jan Humljan ◽  
Katja Kristan ◽  
Uroš Urleb ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Glutamic Acid ◽  
Binding Mode ◽  
Glutamic Acid Derivatives ◽  
Murd Ligase

Prolonged anoxic survival due to anoxia pre-exposure: brain ATP, lactate, and pyruvate

1964 ◽  
Vol 207 (2) ◽  
pp. 452-456 ◽  
Author(s):  
Nancy Ann Dahl ◽  
William M. Balfour
Keyword(s):  
Energy Metabolism ◽  
Survival Time ◽  
Glucose Concentration ◽  
Prolonged Survival ◽  
Anaerobic Glycolysis ◽  
Cerebral Energy Metabolism ◽  
Atp Concentration ◽  
Lactate And Pyruvate ◽  
The Brain

Rats subjected to a brief anoxia can survive go sec in a second anoxia, compared to a 60-sec survival time of control animals. Slower disappearance of ATP concentration in the brain during the second exposure indicates this longer survival is due to an altered cerebral energy metabolism. Initial cerebral ATP concentration is no higher in pre-exposed animals than in controls. When glycolysis is inhibited by iodoacetate before testing in anoxia, the advantage of pre-exposure disappears, suggesting the longer survival may be due to increased anacrobic glycolysis. Lactate accumulates faster during anoxia in the brains of pre-exposed animals than in controls, suggesting that increased anaerobic glycolysis is the cause of the prolonged survival. This effect is not due to increased cerebral glucose concentration. A possible reason for this increased glycolysis, and thus the prolonged survival, could be an increase of a compound, such as pyruvate, capable of oxidizing NADH. The initial pyruvate is higher in pre-exposed animals than in controls and injection of pyruvate increases the survival time slightly.

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