Nano-rods of doxorubicin with poly(l-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment

2016 ◽  
Vol 4 (45) ◽  
pp. 7283-7292 ◽  
Author(s):  
Saina Yang ◽  
Feiyan Zhu ◽  
Qian Wang ◽  
Fuxin Liang ◽  
Xiaozhong Qu ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Cancer Treatment ◽  
Survival Time ◽  
Release Profile ◽  
Intratumoral Administration ◽  
Tumor Bearing ◽  
Carrier Free ◽  
Nano Rods

Nano-rods of doxorubicin (DOX) were prepared by co-assembly with poly(l-glutamic acid) (PGA) and demonstrated a desired release profile for intratumoral administration that significantly prolonged the survival time of tumor-bearing mice.

scholarly journals Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 2337-2348 ◽  
Author(s):  
Kazuo Azuma ◽  
Toshitsugu Ishihara ◽  
Hiroyuki Nakamoto ◽  
Takao Amaha ◽  
Tomohiro Osaki ◽  
...  
Keyword(s):  
Mouse Model ◽  
Oral Administration ◽  
Tumor Growth ◽  
Survival Time ◽  
Tumor Bearing Mouse ◽  
Growth And Survival ◽  
Tumor Bearing ◽  
Cladosiphon Okamuranus

scholarly journals Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1877
Author(s):  
Ivan V. Chernikov ◽  
Daniil V. Gladkikh ◽  
Ulyana A. Karelina ◽  
Mariya I. Meschaninova ◽  
Alya G. Ven’yaminova ◽  
...  
Keyword(s):  
Target Gene ◽  
Drug Resistant ◽  
Small Interfering Rnas ◽  
Tumor Bearing ◽  
Carrier Free ◽  
Free Mode ◽  
Derivatives Of ◽  
Transfection Agent

Cholesterol derivatives of nuclease-resistant, anti-MDR1 small-interfering RNAs were designed to contain a 2’-OMe-modified 21-bp siRNA and a 63-bp TsiRNA in order to investigate their accumulation and silencing activity in vitro and in vivo. The results showed that increasing the length of the RNA duplex in such a conjugate increases its biological activity when delivered using a transfection agent. However, the efficiency of accumulation in human drug-resistant KB-8-5 cells during delivery in vitro in a carrier-free mode was reduced as well as efficiency of target gene silencing. TsiRNAs demonstrated a similar biodistribution in KB-8-5 xenograft tumor-bearing SCID mice with more efficient accumulation in organs and tumors than cholesterol-conjugated canonical siRNAs; however, this accumulation did not provide a silencing effect. The lack of correlation between the accumulation in the organ and the silencing activity of cholesterol conjugates of siRNAs of different lengths can be attributed to the fact that trimeric Ch-TsiRNA lags mainly in the intercellular space and does not penetrate sufficiently into the cytoplasm of the cell. Increased accumulation in the organs and in the tumor, by itself, shows that using siRNA with increased molecular weight is an effective approach to control biodistribution and delivery to the target organ.

scholarly journals Nanomelanin Potentially Protects the Spleen from Radiotherapy-Associated Damage and Enhances Immunoactivity in Tumor-Bearing Mice

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1725 ◽  
Author(s):  
Nguyen Thi Le Na ◽  
Sai Duc Loc ◽  
Nguyen Le Minh Tri ◽  
Nguyen Thi Bich Loan ◽  
Ho Anh Son ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Interleukin 2 ◽  
High Dose Rate ◽  
High Dose ◽  
X Rays ◽  
Necrosis Factor Alpha ◽  
Oh Groups ◽  
X Ray ◽  
Tumor Bearing ◽  
Tnf Α

Radiotherapy side-effects present serious problems in cancer treatment. Melanin, a natural polymer with low toxicity, is considered as a potential radio-protector; however, its application as an agent against irradiation during cancer treatment has still received little attention. In this study, nanomelanin particles were prepared, characterized and applied in protecting the spleens of tumor-bearing mice irradiated with X-rays. These nanoparticles had sizes varying in the range of 80–200 nm and contained several important functional groups such as carboxyl (-COO), carbonyl (-C=O) and hydroxyl (-OH) groups on the surfaces. Tumor-bearing mice were treated with nanomelanin at a concentration of 40 mg/kg before irradiating with a single dose of 6.0 Gray of X-ray at a high dose rate (1.0 Gray/min). Impressively, X-ray caused mild splenic fibrosis in 40% of nanomelanin-protected mice, whereas severe fibrosis was observed in 100% of mice treated with X-ray alone. Treatment with nanomelanin also partly rescued the volume and weight of mouse spleens from irradiation through promoting the transcription levels of splenic Interleukin-2 (IL-2) and Tumor Necrosis Factor alpha (TNF-α). More interestingly, splenic T cell and dendritic cell populations were 1.91 and 1.64-fold higher in nanomelanin-treated mice than those in mice which received X-ray alone. Consistently, the percentage of lymphocytes was also significantly greater in blood from nanomelanin-treated mice. In addition, nanomelanin might indirectly induce apoptosis in tumor tissues via activation of TNF-α, Bax, and Caspase-3 genes. In summary, our results demonstrate that nanomelanin protects spleens from X-ray irradiation and consequently enhances immunoactivity in tumor-bearing mice; therefore, we present nanomelanin as a potential protector against damage from radiotherapy in cancer treatment.

Genetically altered Salmonella typhimurium profoundly increases survival in nude mice with metastatic PC-3 prostate tumors

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14653-14653
Author(s):  
R. M. Hoffman ◽  
M. Zhao ◽  
J. Geller ◽  
M. Yang ◽  
H. Ma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Salmonella Typhimurium ◽  
Survival Time ◽  
Nude Mice ◽  
Normal Tissue ◽  
Potential Treatment ◽  
Human Prostate Cancer ◽  
Progressive Decrease ◽  
The Past ◽  
Tumor Bearing

14653 Background: We previously published that a genetically-altered Salmonella typhimurium, expressing GFP, could completely destroy subcutaneously-implanted PC-3 tumors in nude mice when injected locally or intravenously (PNAS 102, 755–60, 2005). The bacteria are leu-arg auxotrophs which enable the bacteria to grow in PC-3 tumors but not in normal tissue. Methods: In the current study, we explore the effect of this bacteria, termed S. typhimurium A1, on metastatic PC-3 tumors orthotopically implanted in nude mice. PC-3 is a non-hormone-dependent prostate cancer. In this study, 20 mice were implanted orthotopically with PC-3 tumors expressing GFP. Approximately 2 weeks following implantation, the tumors were externally imageable. Ten of the 20 mice served as controls and followed until death without treatment. Ten mice were given the S. typhimurium A1 weekly intravenously, beginning at 2 weeks when the tumor GFP was first externally visible, and survival time was compared to the untreated mice. Ten additional non-tumor-bearing mice served as controls for the possible toxicity of S. typhimurium A1 and were also injected weekly with the bacteria intravenously. Results: Of the 10 mice with the PC-3 tumors injected weekly with S. typhimurium A1, 7 were alive and well at the time the last untreated mouse died. Currently, 4 treated mice remain alive and well 17 weeks following implantation. 3 of these 4 mice had no external fluorescence for the past 5 weeks despite discontinuing S. typhimurium A1. One mouse shows a progressive decrease in fluorescence, only a tiny spot if left. This mouse continues on S. typhimurium injection weekly. Conclusions: Injection of genetically-altered leu-arg-auxotrophic S. typhimurium into mice with metastatic PC-3 tumors has resulted in more than the tripling of lifespan of 4 of the mice. Three of the mice appear “cured” and have not external fluorescence despite discontinuing S. typhimurium treatment for the past 5 weeks. One mouse continues on weekly injections of S. typhimurium and is well with decreasing fluorescence. Since human prostate cancer eventually becomes non-androgen-dependent similar to PC-3 tumors, genetically-altered bacteria represent a novel potential treatment for this disease. No significant financial relationships to disclose.

Three times of intratumor injection of the sustained released by ROS with penicillin-combined chemotherapy drugs for the long of survival period of the tumor-bearing mouse.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e22098-e22098
Author(s):  
Dong Chen ◽  
Qiang Fu ◽  
Jian Zhang ◽  
Yan Han ◽  
Bian Li ◽  
...  
Keyword(s):  
Survival Rate ◽  
Survival Time ◽  
Intratumoral Injection ◽  
Life Extension ◽  
Control Group ◽  
Extension Rate ◽  
Tumor Diameter ◽  
Chemotherapy Drugs ◽  
Tumor Bearing ◽  
Significant Difference

e22098 Background: To study the effect of sustained release by ROS with hapten for three intratumoral injections of chemical drugs on the survival of tumor-bearing mice. Methods: Mice bearing solid tumors of H22 liver cancer were randomly divided into groups with the longest tumor diameter of about 4-7 mm. They were administered intratumorally the next day, with a second interval of 7 days and an interval of 14 days (the 15th day of the experiment). During the period of administration and observation, the death of mice was observed daily, and the time of death was recorded to calculate the life extension rate. Results: The weight of mice in group Ⅲ and group Ⅳ was lower than that in control group, suggesting that chemotherapeutic drugs caused damage of mice and did not significantly increase body weight. Tumor size: Tumor volume experimental groups were different from the Control group, showing a significant anti-tumor effect; but there was no difference compared with Dox Control. Survival The survival rate of each group of mice is closely related to the tumor progression and drug treatment. The survival rate of each group after 45 days of treatment is significantly higher than that of the Control group. The average survival time of group Ⅳ, group Ⅰ and group Ⅱ was longer than that of control group with significant difference. Conclusions: After intratumoral injection 3 times, the survival time of mice is been prolonged.

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for intratumoral administration with improved therapeutic efficacy in tumor-bearing mice

2015 ◽  
Vol 3 (39) ◽  
pp. 7707-7717 ◽  
Author(s):  
Jinyan Lin ◽  
Yanxiu Li ◽  
Yang Li ◽  
Fei Cui ◽  
Fei Yu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Polymeric Nanoparticles ◽  
Intratumoral Administration ◽  
Tumor Bearing ◽  
Highly Efficient

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for highly efficient cancer chemotherapy: more elongated is better.

Addressing the Needs of Children When a Parent Has Cancer

2021 ◽  
pp. 745-752
Author(s):  
Cynthia W. Moore ◽  
Greer J. Dent ◽  
Paula K. Rauch
Keyword(s):  
Cancer Treatment ◽  
Developmental Stage ◽  
Survival Time ◽  
Communication Strategies ◽  
Research Literature ◽  
Parental Cancer ◽  
Open Communication ◽  
Parents And Children ◽  
Key Issues ◽  
The Impact

This chapter reviews key issues of concern for parents with cancer, recognizing that addressing these parenting concerns as part of routine cancer treatment has the potential to alleviate an important source of patient distress. Research literature on the impact of parental cancer on children’s adjustment, and factors associated with better coping, is briefly reviewed. Practical suggestions are made for promoting open communication between parents and children about the parent’s illness and for supporting day-to-day family functioning, particularly when a parent’s prognosis is poor and survival time may be much shorter than hoped. Tables summarize child concerns common to each developmental stage and options for supports at each stage, communication strategies, and suggestions for preparing children for separations and hospital visits.

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