Ameliorative Effect of Captopril and Valsartan on an Animal Model of Diabetic Cardiomyopathy

Despite extensive research efforts, there is no unanimous approval of any animal model to evaluate the toxicity of sulphur mustard [SM; bis (2-chloroethyl) sulphide] or nitrogen mustard [HN-3; tris-(2-chloroethyl) amine] and screening of various prophylactic and therapeutic agents against them. In this study, differential toxicity of mustard agents in higher animal model that is male rabbit was determined. Protective efficacy of DRDE 07 [S-2(2-aminoethylamino) ethyl phenyl sulphide] and its analogues were also evaluated against SM and HN-3 toxicity. Differential toxicity study of SM and HN-3 reveals that both the compounds were more toxic by percutaneous route as compared to subcutaneous route. Till date, there is no recommended drug to counteract SM induced toxicity or mortality in vivo. However, DRDE 07 (an amifostine analogue) and its analogues are found to be very effective protective agents against percutaneously exposed SM in rabbits. The present experiments also showed that SM does not cause skin injury alone but also can cause systemic toxicity as well. DRDE 07 and many of its analogues may prove as prototype compounds for the development of better prophylactic and therapeutic drugs to counter the toxicity of SM or HN-3. In conclusion, rodents and rabbits can be used for the screening of drugs against the blistering agents.

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Ameliorative effect of ethanolic Gymnema sylvestre extract on diabetic cardiomyopathy against streptozotocin-induced diabetes in Wistar rats

International Journal of Green Pharmacy ◽

10.4103/0973-8258.111595 ◽

2013 ◽

Vol 7 (1) ◽

pp. 6 ◽

Cited By ~ 1

Author(s):

Vinay Kumar ◽

Uma Bhandari ◽

ChakraDhar Tripathi ◽

Geetika Khanna

Keyword(s):

Diabetic Cardiomyopathy ◽

Wistar Rats ◽

Gymnema Sylvestre ◽

Ameliorative Effect ◽

Streptozotocin Induced Diabetes

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Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy

PLoS ONE ◽

10.1371/journal.pone.0060931 ◽

2013 ◽

Vol 8 (4) ◽

pp. e60931 ◽

Cited By ~ 80

Author(s):

Sebastián D. Calligaris ◽

Manuel Lecanda ◽

Felipe Solis ◽

Marcelo Ezquer ◽

Jaime Gutiérrez ◽

...

Keyword(s):

Animal Model ◽

Diabetic Cardiomyopathy ◽

High Fat Diet ◽

High Fat ◽

Early Phases

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Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways

Bioscience Biotechnology and Biochemistry ◽

10.1080/09168451.2020.1815170 ◽

2020 ◽

Vol 84 (12) ◽

pp. 2533-2544 ◽

Cited By ~ 1

Author(s):

Yan Wang ◽

Hui Sun ◽

Jianwu Zhang ◽

Zhiyang Xia ◽

Wei Chen

Keyword(s):

Diabetic Cardiomyopathy ◽

Caspase 3 ◽

Ameliorative Effect

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Ameliorative Effect of Flavonoid-rich Extracts from Gongronema latifolium Against Diabetic Cardiomyopathy via serpin A3 and socs3-a in Streptozocin Treated Rats

Biomarkers ◽

10.1080/1354750x.2021.2023220 ◽

2021 ◽

pp. 1-28

Author(s):

Babatunji Emmanuel Oyinloye ◽

B. O. Ajiboye ◽

Oluwafolakemi Johnson ◽

Olutunmise Victoria Owolabi ◽

Jerius Nkwuda Ejeje ◽

...

Keyword(s):

Diabetic Cardiomyopathy ◽

Ameliorative Effect ◽

Gongronema Latifolium

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The ameliorative effect of AST2017-01 in an ovalbumin-induced allergic rhinitis animal model

Inflammation Research ◽

10.1007/s00011-019-01226-y ◽

2019 ◽

Vol 68 (5) ◽

pp. 387-395 ◽

Cited By ~ 4

Author(s):

Hee-Yun Kim ◽

Hyunwoo Jee ◽

Jun-Ho Yeom ◽

Hyun-Ja Jeong ◽

Hyung-Min Kim

Keyword(s):

Animal Model ◽

Allergic Rhinitis ◽

Ameliorative Effect

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Ultrastructural investigation of spontaneous pituitary gonadotroph cell adenomas in aging Sprague-Dawley rats

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100077086 ◽

1983 ◽

Vol 41 ◽

pp. 702-703

Author(s):

D. J. McComb ◽

J. Beri ◽

F. Zak ◽

K. Kovacs

Keyword(s):

Electron Microscopy ◽

Animal Model ◽

Epoxy Resin ◽

Immunoelectron Microscopy ◽

Tumor Type ◽

Gonadal Function ◽

Sprague Dawley ◽

Male And Female ◽

Reticulin Fibers ◽

Sprague Dawley Rats

Gonadotroph cell adenomas of the pituitary are infrequent in human patients and are not invariably associated with altered gonadal function. To date, no animal model of this tumor type exists. Herein, we describe spontaneous gonadotroph cell adenomas in old male and female Sprague-Dawley rats by histology, immunocytology and electron microscopy.The material consisted of the pituitaries of 27 male and 38 female Sprague Dawley rats, all 26 months of age or older, removed at routine autopsy. Sections of formal in-fixed, paraffin-embedded tissue were stained with hematoxylin-phloxine-saffron (HPS), the PAS method and the Gordon-Sweet technique for the demonstration of reticulin fibers. For immunostaining, sections were exposed to anti-rat β-LH, anti-ratβ-TSH, anti-rat PRL, anti-rat GH and anti-rat ACTH 1-39. For electron microscopy, tissue was fixed in 2.5% glutaraldehyde, postfixed in 1% OsO4 and embedded in epoxy-resin. Tissue fixed in 10% formalin, embedded in epoxy resin without osmification, was used for immunoelectron microscopy.

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