Effect of High Glucose Levels on Amyloid β Production in Retinas of Spontaneous Diabetes Mellitus Otsuka Long-Evans Tokushima Fatty Rats

Type 2 diabetes mellitus (T2DM) is a chronic, low-grade inflammation disease. T follicular helper (Tfh) cells and T cell immunoglobulin and mucin domain 3 (Tim-3) are implicated in many immune diseases. This study aims to explore whether Tim-3 expression on Tfh cells is associated with T2DM progression. White blood cells (WBCs) were harvested from 30 patients with T2DM and 20 healthy donors. The abundance of circulating Tfh cells (cTfh) and the frequency of Tim-3 were analyzed by flow cytometry. Levels of fasting plasma glucose (FPG), insulin, hemoglobin A1C (HbA1C), and fasting plasma C-peptide were measured. Body mass index (BMI) and diabetes duration were also recorded. Patients with T2DM had higher numbers of cTfh cells. In addition, cTfh cells showed a negative correlation with HbA1C and diabetes duration, a positive correlation with fasting plasma C-peptide. The frequency of Tim-3 on cTfh cells was higher among T2DM patients compared with healthy donors. The in vitro experiment showed that high glucose levels increased the abundance cTfh cells but had no effect on Tim-3 expression. Our results suggest that cTfh cells and associated Tim-3 frequency may contribute to the progression of T2DM, and high glucose levels may influence cTfh cells directly.

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Gene expression of epithelial glucose transporters: the role of diabetes mellitus.

Journal of the American Society of Nephrology ◽

10.1681/asn.v55s29 ◽

1994 ◽

Vol 5 (5) ◽

pp. S29

Author(s):

J H Dominguez ◽

B Song ◽

L Maianu ◽

W T Garvey ◽

M Qulali

Keyword(s):

Gene Expression ◽

Diabetes Mellitus ◽

Small Intestine ◽

High Glucose ◽

Glucose Transporter ◽

Basolateral Membrane ◽

Glucose Levels ◽

Uncontrolled Diabetes ◽

Extracellular Level

The functions of absorption of dietary glucose by the small intestine and reabsorption of filtered glucose by the renal proximal tubule are strikingly similar in their organization and in the way they adapt to uncontrolled diabetes mellitus. In both cases, transepithelial glucose and Na+ fluxes are augmented. The epithelial adaptations to hyperglycemia of uncontrolled diabetes are accomplished by increasing the glucose transport surface area and the number of the efflux glucose transporter GLUT2 located in the basolateral membrane. The signals that modify the size of the epithelium and the overexpression of basolateral GLUT2 are not known. It was speculated that high glucose levels and enhanced Na+ flux may be important factors in the signaling event that culminates in a renal and intestinal epithelium that is modified to transport higher rates of glucose against a higher extracellular level of glucose.

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Perbandingan Kadar Glukosa Pada Ubi Jalar Ungu (Ipomoea batatas Var Ayamurasaki) Menggunakan Metode Luff Schoorl

WARTA FARMASI ◽

10.46356/wfarmasi.v8i2.86 ◽

2019 ◽

Vol 8 (2) ◽

pp. 10-19

Author(s):

Reymon Reymon ◽

Nur Saadah Daud ◽

Feny Alvianty

Keyword(s):

Diabetes Mellitus ◽

Sweet Potato ◽

High Glucose ◽

Ipomoea Batatas ◽

Degenerative Diseases ◽

Sweet Potatoes ◽

Glucose Levels ◽

Low Carbohydrate ◽

Purple Sweet Potato ◽

Different Levels

ABSTRAK Asupan makanan yang mengandung kadar glukosa tinggi perlu diperhatikan untuk mengurangi risiko penyakit degeneratif seperti diabetes mellitus. Hal ini dapat diatasi dengan mengkonsumsi pangan karbohidrat rendah seperti umbi-umbian seperti ubi jalar ungu(Ipomoea batatasVar Ayamurasaki).Penelitian ini bertujuan untuk mengetahui kadar glukosa yang terdapat pada ubi jalar ungu rebus, kukus, bakar dan goreng. Metode yang digunakan adalah eksperimen. Sampel ubi jalar ungu diolah dengan cara direbus, kukus, bakar dan goreng. Sampel yang telah diolah dianalisis kadar glukosanya dengan menggunakan metode Luff Schoorl secara triplo. Berdasarkan hasil penelitian menunjukkan bahwa semua perlakuan mengandung kadar glukosa dengan tingkat yang berbeda pada sampel ubi jalar ungu rebus, kukus, bakar dan goreng berturut-turut yaitu 3,30%, 4,92%, 7,72%, dan 7,36%. Sehingga dapat disimpulkan kadar glukosa terendah diperoleh dari sampel ubi jalar ungu rebus. Kata kunci : Glukosa, Ubi jalar ungu, Luff Schoorl ABSTRACT Intake of foods containing high glucose levels needs to be considered to reduce the risk of degenerative diseases such as diabetes mellitus. This can be overcome by consuming low carbohydrate foods such as tubers such as purple sweet potato (Ipomoea batatas Var Ayamurasaki).This study aims to determine the glucose levels found in boiled, steamed, roasted and fried purple sweet potatoes. The method used is an experiment. The sample of purple sweet potato is processed by boiling, steaming, roasting and frying. Samples that have been processed are analyzed for glucose levels using the Luff Schoorl method in triple. Based on research results showed that all treatments contained glucose levels with different levels in the samples of purple sweet potato boiled, steamed, roasted and fried respectively at 3.30%, 4.92%, 7.72%, and 7.36%. So that it can be concluded that the lowest glucose level was obtained from a sample of boiled purple sweet potato. Keywords: Glucose, purple sweet potato, Luff Schoorl

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Localization of multidomain adaptor proteins, p140Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka Long-Evans Tokushima Fatty rats

Medical Molecular Morphology ◽

10.1007/s00795-013-0008-1 ◽

2013 ◽

Vol 46 (1) ◽

pp. 41-48 ◽

Cited By ~ 3

Author(s):

Masahiro Yamauchi ◽

Kaori Sudo ◽

Hidenori Ito ◽

Ikuko Iwamoto ◽

Rika Morishita ◽

...

Keyword(s):

Diabetes Mellitus ◽

Pancreatic Islet ◽

Spontaneous Diabetes ◽

Adaptor Proteins ◽

Long Evans

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Hyperglycemia Induced by COVID-19 with and without Present Diabetes: A Systematic Review

KELUWIH: Jurnal Kesehatan dan Kedokteran ◽

10.24123/kesdok.v2i2.4431 ◽

2021 ◽

Vol 2 (2) ◽

pp. 64-74

Author(s):

Gembong Satria Mahardhika

Keyword(s):

Diabetes Mellitus ◽

Glucose Level ◽

High Glucose ◽

Cell Structure ◽

Host Cells ◽

Google Scholar ◽

Morbidity Rate ◽

Mortality And Morbidity ◽

Glucose Levels ◽

English Manuscript

Abstract—COVID-19 is a major emerging disease that affects any certain condition. However, a recent report suggests the occurrence of hyperglycemia without any present diabetes in COVID-19 patients. This study aimed to systematically review recent evidence on hyperglycemia in COVID-19 patients. Literature research was done using four search engines, consist of Google Scholar, PubMed, ScienceDirect, and ProQuest, and limited to English manuscript only and published from February 2020 to September 2020. SARS-CoV-2 could damage the pancreas by causing the destruction of the β-cell structure that leads to impairment of glucose metabolism and worsen pre-existing diabetes or determine the appearance of hyperglycemia in non-diabetes. Inflammation also plays a major important role in hyperglycemia related to COVID-19. Hyperglycemia increased the vulnerability of the lung, by promoting and facilitating the entry of the SARS-CoV-2 into the host cells, and decreasing lung function. Moreover, the mortality and morbidity rate conceivable increased due to hyperglycemia. The presence of high glucose levels is linked with the progression of COVID-19 severity. Thus, the glucose level should be concerned, either in a patient with present diabetes or without any presence of diabetes. Examination and monitoring of glucose levels might be a useful tool to prevent the seriousness of COVID-19 Keywords: diabetes mellitus, SARS-CoV-2, high glucose level, pulmonary infection Abstrak—COVID-19 adalah penyakit yang muncul yang mempengaruhi kondisi tertentu.Namun, sebuah laporan baru-baru ini menunjukkan terjadinya hiperglikemia tanpa adanya diabetes pada pasien COVID-19. Penelitian ini bertujuan untuk meninjau secara sistematis bukti terbaru tentang hiperglikemia pada pasien COVID-19. Penelitian literatur dilakukan dengan menggunakan empat mesin pencari, yaitu Google Scholar, PubMed, ScienceDirect, dan ProQuest, dan terbatas hanya pada manuskrip berbahasa Inggris dan diterbitkan dari Februari 2020 hingga September 2020. SARS-CoV-2 dapat merusak pankreas dengan menyebabkan kerusakan pada pankreas. struktur sel β yang menyebabkan gangguan metabolisme glukosa dan memperburuk diabetes yang sudah ada sebelumnya atau menentukan munculnya hiperglikemia pada kelompok non-diabetes. Peradangan juga memainkan peran penting utama dalam hiperglikemia terkait COVID-19. Hiperglikemia meningkatkan kerentanan paru-paru, dengan mendorong dan memfasilitasi masuknya SARS-CoV-2 ke dalam sel inang, dan menurunkan fungsi paru-paru. Selain itu, angka mortalitas dan morbiditas yang diperkirakan meningkat karena hiperglikemia. Adanya kadar glukosa yang tinggi dikaitkan dengan perkembangan keparahan COVID-19. Dengan demikian, kadar glukosa harus diperhatikan, baik pada pasien dengan diabetes saat ini atau tanpa adanya diabetes. Pemeriksaan dan pemantauan kadar glukosa mungkin menjadi alat yang berguna untuk mencegah derajat keparahan COVID-19. Kata kunci: diabetes mellitus, SARS-CoV-2, peningkatan kadar glukosa, infeksi paru

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257-OR: High Glucose Levels and Risk of Vascular Diseases—Observational Studies and Mendelian Randomization Studies of the General Population

Diabetes ◽

10.2337/db19-257-or ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 257-OR

Author(s):

FRIDA EMANUELSSON ◽

SARAH MAROTT ◽

ANNE TYBJAERG-HANSEN ◽

BØRGE GRØNNE NORDESTGAARD ◽

MARIANNE BENN

Keyword(s):

General Population ◽

High Glucose ◽

Observational Studies ◽

Mendelian Randomization ◽

Vascular Diseases ◽

Glucose Levels

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Efeitos dos Programas de Treinamento Aeróbio, de Força e Combinado na Glicose Sanguínea em Diabéticos do Tipo 2: uma Revisão Sistemática/ Effects of Aerobic, Strength and Combined Programs Training on Blood Glucose in Type 2 Diabetic: a Systematic Review.

REVISTA CIÊNCIAS EM SAÚDE ◽

10.21876/rcsfmit.v5i1.301 ◽

1970 ◽

Vol 5 (1) ◽

pp. 61-74 ◽

Cited By ~ 1

Author(s):

Alexandre de Souza E Silva ◽

Maria Paula Gonçalves Mota

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Type 2 Diabetes ◽

Blood Glucose ◽

Training Program ◽

Aerobic Training ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Pubmed Database

O trabalho tem como objetivo analisar os estudos que avaliaram os efeitos dos programas de treinamento aeróbio, força e combinado nos níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Foi utilizado o método de revisão sistemática, sendo utilizada a base de dados PubMed. As palavras chaves utilizadas para pesquisa foram training and diabetes. Foram identificados 484 artigos originais. Apenas 17 estudos respeitaram os critérios de inclusão. Os resultados evidenciam que os programas de treinamento aeróbio diminuíram os níveis de glicose. O programa de treinamento de força também foi favorável à diminuição dos níveis de glicose sanguínea. Já o programa de treinamento combinado não demonstrou efeitos favoráveis no controle da glicose sanguínea. Conclui-se que o programa de treinamento aeróbio e de força ajudam a controlar os níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Palavras-chave: diabetes mellitus, treinamento, glicose.ABSTRACTThe study aims to analyze the studies that evaluated the effects of aerobic, strength and combined programs training in blood glucose levels in people with type 2 diabetes. We used a systematic review method and is used to PubMed database. The key words used for searching were training and diabetes. We identified 484 original articles. Only 17 studies complied with the inclusion criteria. The results show that aerobic training programs decreased glucose levels. The strength training program was also favorable to decrease in blood glucose levels. But the combined training program has not shown favorable effects on blood glucose control. We conclude that the aerobic training and strength helps control blood glucose levels in individuals with type 2 diabetes. Keywords: diabetes mellitus, training, glucose.

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Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

Clinical Phytoscience ◽

10.1186/s40816-019-0138-7 ◽

2019 ◽

Vol 5 (1) ◽

Author(s):

Musri Musman ◽

Mauli Zakia ◽

Ratu Fazlia Inda Rahmayani ◽

Erlidawati Erlidawati ◽

Safrida Safrida

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Body Weight ◽

Blood Glucose ◽

Phyllanthus Emblica ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Phenolic Extract

Abstract Background Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. Results The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

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