Enhancement Effect of Poly-L-ornithine on the Nasal Absorption of Water-Soluble Macromolecules in Rats

Different formulates of fermented cow and soy milk by Lactobacillus plantarum EMCC 1027 with 50, 100, and 150 mg/100 mL curcumin were investigated for antibacterial, antioxidant, anti-colonic cancer, and anti-inflammation activities. Also, the viability of L. plantarum was monitored during cold storage period. Our results showed that values of antibacterial, antioxidant, anti-colonic cancer, and anti-inflammation activities in crude extracts of fermented soy milk were significantly increased in comparison with crude extracts of fermented cow milk. The addition of different concentrations (100 and 150 mg/100 mL) of curcumin had a significant enhancement effect for all selected health benefits properties. The increase in antioxidant capacity of different crude extracts was in a good correlation with their polyphenols content. Addition of water soluble curcumin did not have any adverse effect on the viability of L. plantarum during fifteen days of cold storage. Therefore, the synergistic effect between fermented cow/soy milk and water soluble curcumin could be recommended. Indeed, extensive research is still needed in order to investigate the molecular mechanisms of health a benefit of different formulates of fermented cow/soy milk and water soluble curcumin.

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Enhancement Effect of Illumination on the Photoluminescence of Water-Soluble CdTe Nanocrystals: Toward Highly Fluorescent CdTe/CdS Core−Shell Structure

Chemistry of Materials ◽

10.1021/cm049172b ◽

2004 ◽

Vol 16 (20) ◽

pp. 3853-3859 ◽

Cited By ~ 323

Author(s):

Haobo Bao ◽

Yanjun Gong ◽

Zhen Li ◽

Mingyuan Gao

Keyword(s):

Shell Structure ◽

Water Soluble ◽

Core Shell ◽

Enhancement Effect ◽

Cdte Nanocrystals ◽

Core Shell Structure

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Transdermal Delivery of Rhizoma Coptidis and Evodia Rutaecarpa: The Effects of Enhancers on Permeation Across SD Mouse Skin

10.21203/rs.3.rs-110148/v1 ◽

2020 ◽

Author(s):

Yu yao Guan ◽

Xue mei Liu ◽

Lei Zheng ◽

Jing Yang ◽

Ji bo Ren ◽

...

Keyword(s):

Acetic Acid ◽

Mouse Skin ◽

Water Soluble ◽

Good Effect ◽

Skin Permeability ◽

Enhancement Effect ◽

Painful Condition ◽

Rhizoma Coptidis ◽

Berberine Hydrochloride ◽

Evodia Rutaecarpa

Abstract Background: Oral ulceration is a common, painful condition of uncertain aetiology. Traditional Chinese medicine has good effect. One kind of treatment method is to use rhizoma coptidis, evodia rutaecarpa powder 10g each mixed with vinegar to paste in the foot springs point. The purpose of this study is to convert this prescription into a corresponding preparation for everyone's convenience. Methods: The enhancement effect of a series of different concentrations of fat-soluble azone, water-soluble azone, dimethyl sulfoxides, acetic acid, on the skin permeability of rhizoma coptidis, evodia rutaecarpa powder was studied in vitro by using Franz diffusion cells and SD mouse skin. The concentrations of the main components palmatine hydrochloride, berberine hydrochloride, evodiamine, rutacarpine in the preparation were determined by an HPLC method. Results: The addition of dimethyl sulfoxide, 2-8% w/w water-soluble azone, 8% w/w fat-soluble azone never increased palmatine hydrochloride and berberine hydrochloride flux with respect to the control preparation. The enhancing effects of 45% acetic acid, 1% water-soluble azone and 5% fat-soluble azone were evident on the palmatine hydrochloride and berberine hydrochloride permeability. The target substances evodiamine and rutacarpine were not detected in the receiving solution, and there were residues in the skin, respectively. The amount of evodiamine and rutacarpine residued in the skin obtained from formulations including 45% w/w acetic acid or 5% w/w fat-soluble azone were significantly higher (p<0.05) than that obtained from the blank control formulation. Conclusions: The experimental results revealed that 5% fat-soluble azone transdermal agent has the optimal performance in the rhizoma coptidis, evodia rutaecarpa preparation.

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Application of Implantable Polylactic-Co-Glycolic Acid Microcapsule in Repairing Alveolar Bone Defects

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/5580785 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Jun Jiang ◽

Jianpeng Xiao ◽

Dongqing Wang ◽

Huazhong Cai

Keyword(s):

Alveolar Bone ◽

Drug Loading ◽

Bone Defects ◽

Water Soluble ◽

Enhancement Effect ◽

Optimum Parameters ◽

Surface Method ◽

Implanted Medical Devices ◽

Poor Absorption ◽

Straightforward Approach

Alveolar bone defects (ABDs) were a perennial problem, especially in the aged. Bisphosphonates, especially etidronate sodium (ET), were frequently used in clinical treatment of ABD. However, the oral administration of ET had poor absorption (<1%). Therefore, optimization of a suitable dosage form substituted with ET to locally repair the ABD was a straightforward approach. Polylactide-co-glycolide (PLGA) is a biodegradable material and had been used in locally implanted medical devices. Therefore, an ET-PLGA microcapsule may help local delivery and prolong the activity of healing ABD. In this paper, a preparation method of ET-PLGA microcapsule was optimized by the single-factor investigation and response surface method. Subsequently, the rat ABD model was used to evaluate the enhancement effect of these microcapsules. Finally, the optimum parameters were determined as follows: 40% dichloromethane, 160 mg/mL PLGA, 10% internal aqua/oil phase, 4% PVA, and emulsifying for 10 min. These microcapsules were spherical in shape and fairly monodisperse in a particle size of 27,51 μm (PDI = 0.3), encapsulation rate 96.6%, and drug loading 4.58%. Compared with the ET groups, the total healing volume of ABD in ET-PLGA groups was significantly increased P < 0.05 . ET-PLGA microcapsules significantly enhanced the effect of ET on ABD. This study provided important technical support for the treatment of ABD with bisphosphonates by local administration. This paper has an exploratory significance for the development of water-soluble bioactive components with low bioavailability for ABD.

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Enhancement Effect of Illumination on the Photoluminescence of Water-Soluble CdTe Nanocrystals: Toward Highly Fluorescent CdTe/CdS Core—Shell Structure.

ChemInform ◽

10.1002/chin.200450011 ◽

2004 ◽

Vol 35 (50) ◽

Author(s):

Haobo Bao ◽

Yanjun Gong ◽

Zhen Li ◽

Mingyuan Gao

Keyword(s):

Shell Structure ◽

Water Soluble ◽

Core Shell ◽

Enhancement Effect ◽

Cdte Nanocrystals ◽

Core Shell Structure

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The effect of molecular size on the nasal absorption of water-soluble compounds in the albino rat

Journal of Pharmacy and Pharmacology ◽

10.1111/j.2042-7158.1987.tb03398.x ◽

1987 ◽

Vol 39 (5) ◽

pp. 357-362 ◽

Cited By ~ 56

Author(s):

A. N. Fisher ◽

K. Brown ◽

S. S. Davis ◽

G. D. Parr ◽

D. A. Smith

Keyword(s):

Molecular Size ◽

Water Soluble ◽

Nasal Absorption ◽

Albino Rat

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A Resorcinol-Formaldehyde Resin as an Embedding Material for Electron Microscopy of Membranes

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010006355x ◽

1969 ◽

Vol 27 ◽

pp. 328-329 ◽

Cited By ~ 1

Author(s):

J. G. Robertson ◽

D. F. Parsons

Keyword(s):

Electron Microscopy ◽

Osmium Tetroxide ◽

Neutral Lipids ◽

Lipid Extraction ◽

Water Soluble ◽

Formaldehyde Resin ◽

Electron Microscope Autoradiography ◽

Resorcinol Formaldehyde ◽

Major Disadvantage ◽

Cell Organization

The extraction of lipids from tissues during fixation and embedding for electron microscopy is widely recognized as a source of possible artifact, especially at the membrane level of cell organization. Lipid extraction is also a major disadvantage in electron microscope autoradiography of radioactive lipids, as in studies of the uptake of radioactive fatty acids by intestinal slices. Retention of lipids by fixation with osmium tetroxide is generally limited to glycolipids, phospholipids and highly unsaturated neutral lipids. Saturated neutral lipids and sterols tend to be easily extracted by organic dehydrating reagents prior to embedding. Retention of the more saturated lipids in embedded tissue might be achieved by developing new cross-linking reagents, by the use of highly water soluble embedding materials or by working at very low temperatures.

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