scholarly journals In Vitro Release of Metoclopramide from Hydrophobic Matrix Tablets. Influence of Hydrodynamic Conditions on Kinetic Release Parameters.

2001 ◽  
Vol 49 (10) ◽  
pp. 1267-1271 ◽  
Author(s):  
Paloma FRUTOS ◽  
Cristina PABÓN ◽  
José L. LASTRES ◽  
Gloria FRUTOS
Keyword(s):  
In Vitro Release ◽  
Matrix Tablets ◽  
Hydrodynamic Conditions ◽  
Hydrophobic Matrix ◽  
Kinetic Release ◽  
Vitro Release

scholarly journals In vitro Release Kinetics Study of Ranolazine from Swellable Hydrophilic Matrix Tablets

1970 ◽  
Vol 8 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Mohammad Nezab Uddin ◽  
Ishtiaq Ahmed ◽  
Monzurul Amin Roni ◽  
Muhammad Rashedul Islam ◽  
Mohammad Habibur Rahman ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Release Kinetics ◽  
In Vitro Release ◽  
High Viscosity ◽  
Matrix Tablets ◽  
Release Studies ◽  
The Matrix ◽  
Vitro Release

The objective of this study was to design oral sustained release matrix tablets of Ranolazine usinghydroxypropyl methylcellulose (HPMC) as the retardant polymer and to study the effect of formulation factors suchas polymer proportion and polymer viscosity on the release of drug. In vitro release studies were performed usingUSP type II apparatus (paddle method) in 900 mL of 0.1N HCl at 100 rpm for 12 hours. The release kinetics wasanalyzed using the zero-order, first order, Higuchi and Korsmeyer-Peppas equations to explore and explain themechanism of drug release from the matrix tablets. In vitro release studies revealed that the release rate decreasedwith increase in polymer proportion and viscosity grade. Mathematical analysis of the release kinetics indicated thatthe nature of drug release from the matrix tablets was dependent on drug diffusion and polymer relaxation andtherefore followed non-Fickian or anomalous release. The developed controlled release matrix tablets of Ranolazineprepared with high viscosity HPMC extended release up to 12 hours.Key words: Ranolazine; Sustained release; Methocel E50 Premium LV; Methocel K100LV CR; Methocel K4M CR;Methocel K15M CR.DOI: 10.3329/dujps.v8i1.5333Dhaka Univ. J. Pharm. Sci. 8(1): 31-38, 2009 (June)

scholarly journals A study on the influence of the formulation factors on in vitro release of ketoprofen from sustained release tablets

2021 ◽  
Vol 14 (1) ◽  
pp. 41-48
Author(s):  
Larisa Cimpoaie ◽  
◽  
Luca Liviu Rus ◽  
Rareș Iuliu Iovanov ◽  
◽  
...  
Keyword(s):  
Sustained Release ◽  
In Vitro Release ◽  
Matrix Tablets ◽  
Inert Matrix ◽  
Sustained Release Tablets ◽  
Formulation Factors ◽  
Release Data ◽  
Vitro Release ◽  
Inert Matrix Tablets

Objectives. The aim of this study was to investigate the influence of formulation factors on in vitro release of ketoprofen from sustained release inert matrix tablets. Materials and methods. Laboratory scale, Ketoprofen sustained release inert matrix tablets were manufactured using Kollidon® SR as matrix formator, by direct tableting of powder blends. The influence of the formulation factors (X1 – matrix formator excipient and X2 – diluent type) on in vitro release of ketoprofen from sustained release tablets was studied by using a full factorial 23 experimental plan. Outcomes. Pharmacotechnical characterization of manufactured laboratory scale batches was performed and all 12 batches fulfilled European Pharmacopeia requests. In vitro release showed a sustained release profile in all cases. Variance analysis (ANOVA) showed a good correlation between experimental conditions and answers. In vitro release testing was performed in phosphate buffer pH = 7.4. Percentage release was determined spectrophotometrically at 258 nm. A decrease in the rate of in vitro release was registered, up to 4 h and 6 h when lactose DC and mannitol DC were used as diluents, respectively. Isomalt DC has increased the rate of in vitro release up to 6 h. Conclusions. In vitro release data, corresponding to formulation N1 shoed a good fitting with Weitbull, Korshmeyer-Peppas and Higuchi models while in vitro release data corresponding to formulation N8 presented a good fitting with Weitbull and Korsmeyer-Peppas. In case of formulations N1 and N8 a non-Fickian diff usion mechanism seems to be involved in drug release from the matrix tablets.

Influence of formulation and process variables on in vitro release of theophylline from directly-compressed Eudragit matrix tablets

Il Farmaco ◽  
2005 ◽  
Vol 60 (11-12) ◽  
pp. 913-918 ◽  
Author(s):  
A. Ceballos ◽  
M. Cirri ◽  
F. Maestrelli ◽  
G. Corti ◽  
P. Mura
Keyword(s):  
In Vitro Release ◽  
Matrix Tablets ◽  
Process Variables ◽  
Vitro Release

Modified in vitro release of the chronobiotic hormone melatonin from matrix tablets based on the marine sulfated polysaccharide ulvan

2018 ◽  
Vol 44 ◽  
pp. 41-48 ◽  
Author(s):  
Marilena Vlachou ◽  
Konstantina Tragou ◽  
Angeliki Siamidi ◽  
Stefanos Kikionis ◽  
Angelos-Leontios Chatzianagnostou ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Sulfated Polysaccharide ◽  
Matrix Tablets ◽  
Vitro Release

scholarly journals Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems

2021 ◽  
Vol 22 (7) ◽  
pp. 3339
Author(s):  
Martyna Zagórska-Dziok ◽  
Patrycja Kleczkowska ◽  
Ewa Olędzka ◽  
Ramona Figat ◽  
Marcin Sobczak
Keyword(s):  
In Vitro Release ◽  
Burst Release ◽  
Skin Cells ◽  
Zero Order Kinetics ◽  
Kinetic Release ◽  
Polymeric Hydrogels ◽  
Fresh Insight ◽  
Vitro Release ◽  
Insight Into

Polymeric hydrogels play an increasingly important role in medicine, pharmacy and cosmetology. They appear to be one of the most promising groups of biomaterials due to their favorable physicochemical properties and biocompatibility. The objective of the presented study was to synthesize new poly(chitosan-ester-ether-urethane) hydrogels and to study the kinetic release of genistein (GEN) from these biomaterials. In view of the above, six non-toxic hydrogels were synthesized via the Ring-Opening Polymerization (ROP) and polyaddition processes. The poly(ester-ether) components of the hydrogels have been produced in the presence of the enzyme as a biocatalyst. In some cases, the in vitro release rate of GEN from the obtained hydrogels was characterized by near-zero-order kinetics, without "burst release" and with non-Fickian transport. It is important to note that developed hydrogels have been shown to possess the desired safety profile due to lack of cytotoxicity to skin cells (keratinocytes and fibroblasts). Taking into account the non-toxicity of hydrogels and the relatively highly controlled release profile of GEN, these results may provide fresh insight into polymeric hydrogels as an effective dermatological and/or cosmetological tool.

Chronobiotic Hormone Melatonin: Comparative in vitro Release Studies from Matrix Tablets and Liposomal Formulations

2017 ◽  
Vol 14 (4) ◽  
pp. 476-480 ◽  
Author(s):  
Androniki Zampakola ◽  
Angeliki Siamidi ◽  
Natassa Pippa ◽  
Costas Demetzos ◽  
Marilena Vlachou
Keyword(s):  
In Vitro Release ◽  
Matrix Tablets ◽  
Liposomal Formulations ◽  
Release Studies ◽  
Vitro Release
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