Effect Of Exercise Intensity On Postprandial Lipemia And Oxidative Stress Markers After A High-fat Meal

The medicinal plantsArtemisia iwayomogi(A. iwayomogi) andCurcuma longa(C. longa) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM). In this study we evaluated the effect of the water extract of a mixture ofA. iwayomogiandC. longa(ACE) on high-fat diet-induced metabolic syndrome in a mouse model. Four groups of C57BL/6N male mice (except for the naive group) were fed a high-fat diet freely for 10 weeks. Among these, three groups (except the control group) were administered a high-fat diet supplemented with ACE (100 or 200 mg/kg) or curcumin (50 mg/kg). Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed. ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPARγ; fatty acid synthase, FAS; sterol regulatory element-binding transcription factor-1c, SREBP-1c; and peroxisome proliferator-activated receptor alpha, PPARα). The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model.

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Effects of Two Combined Exercise Designs Associated With High-Fat Meal Consumption on Postprandial Lipemia, Insulinemia, and Oxidative Stress

The Journal of Strength and Conditioning Research ◽

10.1519/jsc.0000000000001984 ◽

2018 ◽

Vol 32 (5) ◽

pp. 1422-1430

Author(s):

Juliano B. Farinha ◽

Carlos Ernani O. Macedo ◽

Josianne Rodrigues-Krause ◽

Renata L. Krüger ◽

Francesco P. Boeno ◽

...

Keyword(s):

Oxidative Stress ◽

Postprandial Lipemia ◽

High Fat ◽

Combined Exercise ◽

And Oxidative Stress ◽

Fat Meal ◽

Meal Consumption

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Acute Administration of Tibolone Prevents Oxidative Stress in Ovariectomized Rats Fed High-Fat-and-Fructose Diet

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-0659-9928 ◽

2018 ◽

Vol 127 (06) ◽

pp. 396-404 ◽

Cited By ~ 3

Author(s):

Norma Angélica Estrada Cruz ◽

Julio César Almanza Pérez ◽

Ángeles Fortis Barrera ◽

Juan Manuel Gallardo ◽

Leticia Manuel Apolinar ◽

...

Keyword(s):

Oxidative Stress ◽

Enzymatic Activity ◽

Metabolic Parameters ◽

Ovariectomized Rats ◽

Acute Administration ◽

Oxidative Stress Markers ◽

High Fat ◽

Glucose Levels ◽

Stress Markers ◽

And Oxidative Stress

AbstractIn addition to oxidative stress due to the increase of free radicals, estrogen deficiency is associated with changes in enzymatic activity, glutathione redox ratio (GSH/GSSG), and the content of oxidative markers such as malondialdehyde. Tibolone, a synthetic steroid, has been used as an elective treatment for the relief of menopausal symptoms. However, the acute effects of hormonal therapy with tibolone on metabolic parameters and oxidative stress markers associated with the first stages of estrogen deficiency are still unknown. The study aimed to evaluate if the acute administration of tibolone reduces oxidative stress in ovariectomized rats fed high-fat-and-fructose diet. Rats were fed a standard diet or a diet consisting of 10% lard-supplemented chow and 20% high-fructose syrup in the drinking water plus tibolone or vehicle for seven days. Weight, cholesterol, triglycerides, and glucose levels, as well as antioxidant enzymes and oxidative stress markers were quantified in the serum of each experimental group. It was observed that seven days of diet and tibolone treatment in the ovariectomized group reduced weight, triglycerides, cholesterol, glucose levels and advanced glycation end products but did not change GSH/GSSG ratio nor the enzymatic activity of superoxide dismutase. Also, both glutathione peroxidase and glutathione reductase activity decreased, as well as malondialdehyde levels. These results suggest that the acute treatment with tibolone prevented the changes in the metabolic parameters analyzed as well as the increase in the levels of malondialdehyde and AGEs induced by ovariectomy and high-fat diet.

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