scholarly journals Age-Related Differences in the Clinical Characteristics and Treatment of Elderly Patients With Atrial Fibrillation in Japan　― Insight From the ANAFIE (All Nippon AF In Elderly) Registry ―

2020 ◽  
Vol 84 (3) ◽  
pp. 388-396 ◽  
Author(s):  
Ken-ichi Hiasa ◽  
Hidetaka Kaku ◽  
Hiroshi Inoue ◽  
Takeshi Yamashita ◽  
Masaharu Akao ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Elderly Patients ◽  
Clinical Characteristics ◽  
Age Related

scholarly journals Clinical characteristics of super-elderly patients with atrial fibrillation: from the Fushimi AF registry

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4275-P4275
Author(s):  
Y. Yamashita ◽  
M. Esato ◽  
Y. H. Chun ◽  
H. Tsuji ◽  
H. Wada ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Elderly Patients ◽  
Clinical Characteristics

scholarly journals Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tatyana V. Sukhacheva ◽  
Natalia V. Nizyaeva ◽  
Maria V. Samsonova ◽  
Andrey L. Cherniaev ◽  
Artem A. Burov ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Mitral Valve Regurgitation ◽  
Ultrastructural Level ◽  
Cardiomyocyte Hypertrophy ◽  
Myocardial Remodeling ◽  
Valve Regurgitation ◽  
Atrial Myocardium ◽  
Functional Changes ◽  
Age Related ◽  
Transitional Forms

AbstractTelocytes are interstitial cells with long, thin processes by which they contact each other and form a network in the interstitium. Myocardial remodeling of adult patients with different forms of atrial fibrillation (AF) occurs with an increase in fibrosis, age-related isolated atrial amyloidosis (IAA), cardiomyocyte hypertrophy and myolysis. This study aimed to determine the ultrastructural and immunohistochemical features of cardiac telocytes in patients with AF and AF + IAA. IAA associated with accumulation of atrial natriuretic factor was detected in 4.3–25% biopsies of left (LAA) and 21.7–41.7% of right (RAA) atrial appendage myocardium. Telocytes were identified at ultrastructural level more often in AF + IAA, than in AF group and correlated with AF duration and mitral valve regurgitation. Telocytes had ultrastructural signs of synthetic, proliferative, and phagocytic activity. Telocytes corresponded to CD117+, vimentin+, CD34+, CD44+, CD68+, CD16+, S100-, CD105- immunophenotype. No significant differences in telocytes morphology and immunophenotype were found in patients with various forms of AF. CD68-positive cells were detected more often in AF + IAA than AF group. We assume that in aged AF + IAA patients remodeling of atrial myocardium provoked transformation of telocytes into “transitional forms” combining the morphological and immunohistochemical features with signs of fibroblast-, histiocyte- and endotheliocyte-like cells.

Impact of frailty and atrial fibrillation in elderly patients with acute coronary syndromes

2021 ◽  
Vol 51 (5) ◽  
Author(s):  
María Asunción Esteve‐Pastor ◽  
Ernesto Martín ◽  
Oriol Alegre ◽  
Francesc Formiga ◽  
Juan Sanchís ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Elderly Patients ◽  
Acute Coronary Syndromes ◽  
Coronary Syndromes

scholarly journals The safety of catheter ablation of atrial fibrillation in elderly patients -analysis of the nationwide database in Japan, JROAD-DPC-

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y Yokoyama ◽  
K Miyamoto ◽  
M Nakai ◽  
Y Sumita ◽  
N Ueda ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Elderly Patients ◽  
Complication Rate ◽  
Safety Data ◽  
Public Institution ◽  
Funding Source ◽  
Chads2 Score ◽  
Aged Patients ◽  
Nationwide Database

Abstract Background “Age” is one of the major concerns and determinants of the indications for catheter ablation (CA) of atrial fibrillation (AF). There are little safety data on CA of AF according to the age. This study aimed to assess the safety of CA in elderly patients undergoing CA of AF. Methods and results We investigated the complication rate of CA of AF for the different age groups (<60 years, 60–65, 65–70, 70–75, 75–80, 80–85, and ≥85) by a nationwide database (Japanese Registry Of All cardiac and vascular Diseases [JROAD]-DPC). The JROAD-DPC included 73,296 patients (65±11 years, 52,883 men) who underwent CA of AF from 516 hospitals in Japan. Aged patients had more comorbidities and a significantly increased CHADS2 score and higher rate of female according to a higher age. The overall complication rate was 2.6% and in-hospital mortality was 0.05%. By comparing each age group, complications occurred more frequently in higher aged groups. A multivariate adjusted hazard ratio revealed an increased age was independently and significantly associated with the overall complications (odds ratio was 1.25, 1.35, 1.72, 1.86, 2.76 and 3.13 respectively; reference <60 years). Conclusions The frequency of complications was significantly higher according to a higher age. We should take note of the indications and procedure for CA of AF in aged patients. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): Intramural Research Fund 17 (Kusano) for Cardiovascular Diseases of the National Cerebral and Cardiovascular Center

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