scholarly journals Pathogenetic Mechanisms of Bronchial Asthma and Airway Hyperresponsiveness: A Pharmacological View. Possible role of nitric oxide in NANC relaxation of the airway and in airway hyperreactivity in airway disease.

1998 ◽  
Vol 111 (4) ◽  
pp. 205-215
Author(s):  
Yushi ITO ◽  
Kanichiro FUJISAWA
Keyword(s):  
Nitric Oxide ◽  
Bronchial Asthma ◽  
Airway Hyperresponsiveness ◽  
Airway Disease ◽  
Airway Hyperreactivity ◽  
Pathogenetic Mechanisms ◽  
Nanc Relaxation

Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses toAspergillus fumigatus

2002 ◽  
Vol 283 (1) ◽  
pp. L198-L204 ◽  
Author(s):  
Jane M. Schuh ◽  
Kate Blease ◽  
Steven L. Kunkel ◽  
Cory M. Hogaboam
Keyword(s):  
T Cell ◽  
Airway Hyperresponsiveness ◽  
Airway Disease ◽  
Allergic Airway Disease ◽  
Th2 Cells ◽  
Wild Type ◽  
Cell Recruitment ◽  
Chronic Model ◽  
Airway Responses

Eotaxin/CCL11 is a major chemoattractant for eosinophils and Th2 cells. As such, it represents an attractive target in the treatment of allergic disease. The present study addresses the role of eotaxin/CCL11 during acute and chronic allergic airway responses to the fungus Aspergillus fumigatus. Mice lacking the eotaxin gene (Eo−/−) and wild-type mice (Eo+/+) were sensitized to A. fumigatus and received either an intratracheal challenge with soluble A. fumigatusantigens (acute model) or an intratracheal challenge with live A. fumigatus spores or conidia (chronic model). Airway hyperresponsiveness and eosinophil, but not T cell, recruitment were significantly decreased at 24 h after the soluble allergen in A. fumigatus-sensitized Eo−/− mice compared with similarly sensitized Eo+/+ mice. In contrast, the development of chronic allergic airway disease due to A. fumigatus conidia was not altered by the lack of eotaxin. Together, these data suggest that eotaxin initiates allergic airway disease due to A. fumigatus, but this chemokine did not appear to contribute to the maintenance of A. fumigatus-induced allergic airway disease.

scholarly journals Modulatory Effects of L-Arginine on Methylxanthine-Induced Cardiotoxicity in Rats: A Differential Role for Nitric Oxide (NO)

2021 ◽  
pp. 1-6
Author(s):  
Arunabha Ray ◽  
Md Shamsuzzaman ◽  
Jagdish C. Joshi ◽  
Kavita Gulati ◽  
Arunabha Ray
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Adverse Effect ◽  
Troponin I ◽  
Therapeutic Index ◽  
Airway Disease ◽  
Cardiac Biomarkers ◽  
Qtc Interval ◽  
Beneficial Effects

Methylxanthines are potent bronchodilators used in obstructive airway disease like COPD and bronchial asthma, but the narrow therapeutic index and resultant adverse effect profile have restricted their use. Novel beneficial effects and modes of action are now being proposed for these pharmacoeconomically viable agents. Cardiotoxicity is a prominent adverse effect of methylxanthone and thus we investigated possible mechanisms for such toxicity with an aim to devise ameliorative strategies for counteracting such undesirable effects. In view of the cardioprotective role of nitric oxide (NO) and NO mimetics, the present study investigated the possible modulatory role of L-arginine, a NO precursor, in theophylline induced cardiotoxicity in rats, with a view to exploring strategies for facilitating the safe use of this drug. The methylxanthine, aminophylline induced cardiotoxic effects like increased heart rat, raised mean BP, inverted T-waves and prolonged QTc interval (in ECG). These were accompanied by increased levels of cardiac biomarkers like Troponin-I, CPK-MB, and ADMA. Oxidative stress markers like MDA were elevated whereas, antioxidant defence markers like GSH and SOD were suppressed. Co-administration of L-arginine (with aminophylline) had dose-related effects on cardiac function (heart rate, mean BP, ECG changes) and cardiospecific biomarkers (TnI, CPK-MB, ADMA) - the lower dose being protective whereas the higher dose potentiating some of the cardiac effects and cardiospecific/oxidative stress biomarker levels. The results indicate a biphasic involvement of NO in the cardiotoxic effect of theophylline and suggests possible interactions of NO with reactive oxygen species during such modulations of cardiotoxicity.

scholarly journals Role of nitric oxide in the development and partial reversal of allergen-induced airway hyperreactivity in conscious, unrestrained guinea-pigs

1998 ◽  
Vol 123 (7) ◽  
pp. 1450-1456 ◽  
Author(s):  
Martin Schuiling ◽  
Annet B. Zuidhof ◽  
Monique A. A. Bonouvrie ◽  
Nicolette Venema ◽  
Johan Zaagsma ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Guinea Pigs ◽  
Airway Hyperreactivity ◽  
Partial Reversal
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