scholarly journals Healing process of acetic acid-induced gastric ulcer and gastric mucosal prostaglandin E generation level in rats.

1989 ◽  
Vol 50 (3) ◽  
pp. 366-368 ◽  
Author(s):  
Masayuki UCHIDA ◽  
Osamu KAWANO ◽  
Noriyuki MISAKI ◽  
Osamu IRINO
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Healing Process ◽  
Prostaglandin E ◽  
Generation Level

scholarly journals Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers

2008 ◽  
Vol 51 (4) ◽  
pp. 479-483 ◽  
Author(s):  
Cristina Setim Freitas ◽  
Cristiane Hatsuko Baggio ◽  
Samanta Luiza Araújo ◽  
Maria Consuelo Andrade Marques
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Acute Toxicity ◽  
Aqueous Extract ◽  
Healing Process ◽  
Intraperitoneal Administration ◽  
Oral Route ◽  
Chronic Gastric Ulcer ◽  
Pfaffia Glomerata ◽  
Tissue Healing

The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral route. The administration of the AEP did not prevent ulcers formation. However, the AEP increased of the healing process of previously induced ulcers. The results suggest that AEP chronically administered promote an increase of tissue healing, after the damage induced by acetic acid and the extract seemed to be destituted of toxic effects in the mice by the oral route.

scholarly journals Evaluation of Therapeutic Efficacy of Stigma and Petal Extracts of Crocus sativus L. on Acetic Acid-Induced Gastric Ulcer in Rats

2021 ◽  
Author(s):  
Mahtab Mohammadifard ◽  
Hossein Javdani ◽  
Ghazaleh Khalili-Tanha ◽  
Ali Farahi ◽  
Mohsen Foadoddini ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Healing Process ◽  
Crocus Sativus ◽  
Gastric Ulcers ◽  
Control Group ◽  
Dependent Manner ◽  
Ulcer Size ◽  
Ethanolic Extracts ◽  
Crocus Sativus L

Saffron (Crocus sativus L.) has long been considered a medicinal plant in Traditional Persian Medicine (TPM) due to its therapeutic properties. Despite this interest, its effects on gastrointestinal disorders have not been completely taken into consideration. Hence, this study aimed to evaluate the pharmacological activity of ethanolic extracts of saffron stigma (SS) and saffron petal (SP) in acetic acid-induced gastric ulcer in rats. The gastric ulcer model was imitated by the serosal application of acetic acid in male Wistar rats. Then, the animals were orally fed with 100 mg/kg and 200 mg/kg of ethanolic extracts of SS or SP, omeprazole (40 mg/kg), or saline for 12 days. The macroscopic and microscopic appearances of gastric ulcers and the levels of malondialdehyde (MDA), vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE2) in gastric tissues were assessed. The highest anti-ulcer activity was observed in the omeprazole-treated animals with the lowest ulcer size (4.29 ± 1.78 mm2). SS could not reduce gastric ulcer size in rats. Compared to the untreated rats, SP treatment significantly decreased ulcer indices in a dose-dependent manner. The gastric levels of PGE2, VEGF, and MDA were significantly elevated in the untreated animals with gastric ulcers compared to rats in the control group. The SS extract suppressed the elevated PGE2 and VEGF levels at both doses, while SP did not have a significant influence. Both SS and SP treatments significantly ameliorated MDA levels in rats with gastric ulcers. Omeprazole treatment enhanced the PGE2 level and suppressed MDA contents, but it did not influence the VEGF level. In conclusion, our findings demonstrated that the saffron stigma has no significant effects on the gastric ulcer healing process, while its petals accelerate the process. This discrepancy can be attributed to the difference in the main secondary metabolites between saffron stigma and petals.

W1563 Roles of An Inducible Prostaglandin E Synthase, mPGES-1 in the Healing of Acetic Acid-Induced Gastric Ulcer and Angiogenesis

2009 ◽  
Vol 136 (5) ◽  
pp. A-692
Author(s):  
Takako Ae ◽  
Takashi Ohno ◽  
Youichiro Hattori ◽  
Katsunori Saigenji ◽  
Masataka Majima
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Prostaglandin E ◽  
Prostaglandin E Synthase

Increased expression of an amino acid transporter LAT1 in healing of acetic acid-induced chronic gastric ulcer in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A153-A153
Author(s):  
S MIYAMOTO ◽  
K KATO ◽  
Y ISHII ◽  
S ASAI ◽  
T NAGAISHI ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Amino Acid ◽  
Amino Acid Transporter ◽  
Chronic Gastric Ulcer ◽  
Acid Transporter

Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tosan Peter Omayone ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Acetic Acid ◽  
Untreated Control ◽  
Wistar Rats ◽  
Low Dose ◽  
Healing Process ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Haematological Changes ◽  
Therapeutic Properties ◽  
Histopathological Effects

Abstract Objectives Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats. Methods Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment. Results Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA. Conclusions Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.

Comparison Between Omental Implantation and Omental Patch for Perforated Acetic Acid-Induced Gastric Ulcer in Rats

2005 ◽  
Vol 13 (1) ◽  
pp. A14-A14
Author(s):  
Yasunori Matoba ◽  
Akira Tokunaga ◽  
Yukichi Moriyama ◽  
Shinya Iida ◽  
Norio Matsukura ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Omental Patch

scholarly journals Rabbit gastric ulcer models: comparison and evaluation of acetic acid-induced ulcer and mucosectomy-induced ulcer

2013 ◽  
Vol 29 (2) ◽  
pp. 96 ◽  
Author(s):  
Jin Hee Maeng ◽  
Eunhye Lee ◽  
Don Haeng Lee ◽  
Su-Geun Yang
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Models Comparison

scholarly journals Ulcer Protective and Ulcer Healing Activities of Aqueous and Methanolic Extracts of Leaves of Rumex Bequaertii De Wild (Polygonaceae) in Rats

2015 ◽  
Vol 6 (2) ◽  
pp. 61
Author(s):  
Gilbert Ateufack ◽  
Breuil R. Dongmo Feudjio ◽  
William Nana Yousseu ◽  
Albert D. Atsamo ◽  
Albert Kamanyi
Keyword(s):  
Acetic Acid ◽  
Significant Variation ◽  
Healing Process ◽  
Negative Control ◽  
Chronic Ulcer ◽  
Male Rats ◽  
Control Group ◽  
Traditional Use ◽  
Mucus Production ◽  
Methanolic Extracts

The aqueous and methanolic extracts of Rumex bequaertii leaves were investigated for their ability to prevent and treated ulceration of the gastric mucosa in animal models.For this, adult male rats three to four months old and weighing on average 180 g were used for both tests. The extracts were tested orally at doses of 125, 250 and 500 mg/kg, on ulcerations experimentally induced by HCl/ethanol and pylorus ligation (acute ulcer) and acetic acid (chronic ulcer).These extracts showed protective and healing properties on ulcer induced models. A dose of 500 mg/kg of the two extracts inhibited ulceration induced by HCl/ethanol by 98.86 and 91.59 % respectively. With pyloric ligation, no significant variation of the volume of gastric juices, pH and gastric acidity was observed compared to the negative control rats. The aqueous extract alone at different doses presented a significant reduction of the ulceration surface resulting from chronic ulcer induced with acetic acid compared to the negative control group that received distilled water. For all three models of gastric ulcer induction used, the mass of mucus significantly increased in the groups that received the extracts. There was no significant variation in plasmatic nitric oxide (NO) concentrationand gastric supernatant of rats treated with both extracts compared to both control groups. These results reveal that the healing process of the extracts is not achieved through the NO pathway. This process could be due to increase in mucus production and thus supports its traditional use of the plant

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