Comparison Between Omental Implantation and Omental Patch for Perforated Acetic Acid-Induced Gastric Ulcer in Rats

The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral route. The administration of the AEP did not prevent ulcers formation. However, the AEP increased of the healing process of previously induced ulcers. The results suggest that AEP chronically administered promote an increase of tissue healing, after the damage induced by acetic acid and the extract seemed to be destituted of toxic effects in the mice by the oral route.

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Effect of aqueous extract of aloe vera leaves on gut-brain axis response following acetic acid -induced gastric ulcer in male rats

Journal of North Khorasan University of Medical Sciences ◽

10.29252/jnkums.6.2.347 ◽

2014 ◽

Vol 6 (2) ◽

pp. 347-357

Author(s):

M Sabaghian ◽

Z Keshavarzi ◽

B Bibak ◽

M Vatanchian ◽

T Mohammad Rezapour

Keyword(s):

Acetic Acid ◽

Gastric Ulcer ◽

Aqueous Extract ◽

Aloe Vera ◽

Male Rats

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Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

International Journal of Molecular Sciences ◽

10.3390/ijms21072577 ◽

2020 ◽

Vol 21 (7) ◽

pp. 2577 ◽

Cited By ~ 3

Author(s):

Cuizhu Wang ◽

Yuze Yuan ◽

He Pan ◽

Alan Chen-Yu Hsu ◽

Jinluan Chen ◽

...

Keyword(s):

Nitric Oxide ◽

Acetic Acid ◽

Gastric Ulcer ◽

Growth Factor ◽

Gastric Mucosa ◽

Epidermal Growth Factor ◽

Serum Levels ◽

Gastroprotective Effect ◽

Epidermal Growth ◽

Oxide Synthase

Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the Panax genus, possesses good anti-inflammatory activity. The study aimed to investigate the gastroprotective effect of ocotillol on acetic acid-induced GU rats. The serum levels of endothelin-1 (ET-1) and nitric oxide (NO), the gastric mucosa levels of epidermal growth factor, superoxide dismutase and NO were assessed. Hematoxylin and eosin staining of gastric mucosa for pathological changes and immunohistochemical staining of ET-1, epidermal growth factor receptors and inducible nitric oxide synthase were evaluated. A UPLC-QTOF-MS-based serum metabolomics approach was applied to explore the latent mechanism. A total of 21 potential metabolites involved in 7 metabolic pathways were identified. The study helps us to understand the pathogenesis of GU and to provide a potential natural anti-ulcer agent.

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