A case of sensorineural deafness following ingestion of Ecstasy

2001 ◽  
Vol 115 (11) ◽  
pp. 911-915 ◽  
Author(s):  
A. Sharma
Keyword(s):  
Side Effects ◽  
Young People ◽  
Side Effect ◽  
Sensorineural Deafness ◽  
History Of

Ecstasy is a substance of abuse commonly associated with the dance scene and taken by many young people. A brief history of Ecstasy and its side-effects is given. A case of ototoxicity is presented, as an additional side-effect to the long list of complications caused by Ecstasy.

Dermal Discoloration Secondary to Triamcinolone Acetonide Injection Observed in Patients with Autoimmune Disorders

2021 ◽  
Vol 111 (4) ◽  
Author(s):  
James A. Wright ◽  
Jessica A. Wenz ◽  
Gabrielle Jackson Madrigal
Keyword(s):  
Psoriatic Arthritis ◽  
Side Effects ◽  
Autoimmune Disease ◽  
Triamcinolone Acetonide ◽  
Current Literature ◽  
Side Effect ◽  
Inflammatory Conditions ◽  
Rare Side Effect ◽  
History Of ◽  
Synthetic Glucocorticoid

Triamcinolone acetonide is a synthetic glucocorticoid used to treat numerous acute and chronic inflammatory conditions. The various side effects of this drug from parenteral administration are well documented in the literature. In this study, three patients present with a rare side effect of violaceous dermal pigmentation. To the best of the authors' knowledge, this finding is rarely presented in the current literature. The purpose of this study is to provide awareness of a less-documented, delayed side effect from triamcinolone acetonide administration. Although all patients presenting in this study had a known history of autoimmune disease (eg, lupus, psoriatic arthritis) further research is needed to suggest a possible association between dermal violaceous change and the use of triamcinolone.

Increased libido as a buproion-SR side effect: Clinical description of a case

2016 ◽  
Vol 33 (S1) ◽  
pp. S545-S545 ◽  
Author(s):  
L. Gallardo Borge ◽  
C. Noval Canga ◽  
L. Rodíguez Andrés ◽  
I. Sevillano Benito ◽  
M. Hernández García ◽  
...  
Keyword(s):  
Side Effects ◽  
Sexual Dysfunction ◽  
Side Effect ◽  
Muscle Tension ◽  
Negative Influence ◽  
Sexual Life ◽  
Clinical Report ◽  
Consultation Room ◽  
Sexual Side Effects ◽  
History Of

IntroductionBupropion is a dual antidepressant, a norepinephrine and dopamine reuptake inhibitor. Its main use is in affective disorders as major depression. Antidepressants have been commonly associated with sexual side effects in the libido, sexual arousal, orgasm and erectile function. Bupropion has negative influence in sexual function, even it could increase the libido. Due to this, it could be a good option in patients with active sexual life and affective disorder.Clinical reportA 58-year-old female with a long history of depression disorder for 5 years. History of lots of side effects with different treatments, sexual dysfunction with serotonin-antidepressants. Treated with bupropion SR 150 mg/day and alprazolam, she suffered a relapse. The bupropion was increased to 300 mg/day. Three days later she appeared in the consultation room, presented a sense of pre-orgasmic of 72 hours of evolution, high increased libido, tiredness, muscle tension and insomnia. This sense did not improve after the sexual act. It had never happened previously. The side effect improved when the bupropion was reduced to 150 mg/day and disappeared with its withdrawal.ConclusionsThe case made a relationship between the increased of bupropion's dose and the appearance of unusual sexual side effects (increased of libido and pre-orgasmic sense). Not only bupropion is one of the antidepressants that do not cause sexual dysfunction, if not it was reported in some trials that could be a treatment against this dysfunction due to its prosexual effects. The mechanism is unknown but could be related with norepinephrine or dopamine transmission.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Safety Monitoring of COVID Vaccines and Perception of Post-vaccination Side-Effects: Preliminary Findings From The First Month of Routine Monitoring in a Hospital Vaccination Setting of China

2021 ◽  
Author(s):  
Aihua Feng ◽  
Ruoyan Gai Tobe ◽  
Yongqiang Wang ◽  
Ting Yang ◽  
Xiuting Mo ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Side Effects ◽  
Side Effect ◽  
Safety Monitoring ◽  
Affecting Factors ◽  
Post Vaccination ◽  
Perceived Safety ◽  
Vaccination Uptake ◽  
Routine Monitoring ◽  
History Of

Abstract Objectives: This study aims to explore the occurrence of post-vaccination side-effects from COVID-19 vaccines and its affecting factors in a hospital vaccination setting of China.Results: A total of 811 vaccinees aged 17 to 58 years, who finished the full package of two doses in February 2021, have been recruited at the second vaccination uptake. Among all, there have been 66 participants who reported one or more mild side effects, while none of them developed severe cases. Those with history of immune deficiency were more likely to report side effect(s). Although with several concerns, most participants showed willingness to get vaccinated (98.8%) with relevant high proportions of perceived safety (99.5%) and effectiveness (97.3%).

scholarly journals Prilocaine-Induced Methemoglobinemia

2020 ◽  
Vol 3 (2) ◽  
pp. 25-28 ◽  
Author(s):  
Alpay Medetalibeyoğlu ◽  
Elif Sitre Koç ◽  
Oyku Beyaz ◽  
Ahmed Edizer
Keyword(s):  
Respiratory Failure ◽  
Side Effects ◽  
Side Effect ◽  
Correct Diagnosis ◽  
Severe Side Effect ◽  
Neurological Manifestations ◽  
Surface Areas ◽  
History Of ◽  
History Of Anesthesia ◽  
Systemic Side Effects

Local anesthetics are used to anesthetize surface areas in several procedures. The history of anesthesia exposure has been established as an important factor for correct diagnosis. When they are used excessively, some systemic side effects such as methemoglobinemia, respiratory failure, cardiovascular arrhythmias, or neurological manifestations may occur. Methemoglobinemia which usually presents with nonspecific symptoms is a serious entity. It is a rare but severe side effect of anesthetics. We herein present a case of methemoglobinemia due to local anesthesia with prilocaine.

scholarly journals Natural History of Paclitaxel-associated Acute Pain Syndrome: A Case Report of Rare Side Effect of Paclitaxel

2021 ◽  
Vol 9 (C) ◽  
pp. 239-242
Author(s):  
Siti Salima ◽  
Ali Budi Harsono ◽  
Aisyah Aisyah ◽  
Kemala Mantilidewi
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Acute Pain ◽  
Side Effect ◽  
Supportive Therapy ◽  
Pain Syndrome ◽  
Rare Side Effect ◽  
History Of ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

BACKGROUND: One of the harshest side effects following anticancer agent treatments is chemotherapy-induced neuropathic pain. After surgical staging, chemotherapy combination of paclitaxel carboplatin could be a choice of therapy for Stage II or more advanced stage of ovarian cancer. Different side effects may appear after the application of paclitaxel. CASE REPORT: Here, we show an uncommon case of paclitaxel-acute pain syndrome (P-APS), and how we deal with such cases according to our experiences. One uncommon side effect is P-APS, which can be treated effectively with the administration of non-steroidal anti-inflammatory drugs, corticosteroid, and supportive therapy. CONCLUSION: One uncommon side effect of Paclitaxel induced neuropathic can be treated effectively with the administration of non-steroidal anti inflammatory drugs, corticosteroid, and supportive therapy.

Was Christianity a Monotheistic Faith from the Beginning?

1982 ◽  
Vol 35 (4) ◽  
pp. 303-336 ◽  
Author(s):  
James D. G. Dunn
Keyword(s):  
Side Effects ◽  
New Testament ◽  
Side Effect ◽  
Human Form ◽  
The New Testament ◽  
History Of ◽  
Christian Origins

Students of the New Testament will be familiar with the influential hypothesis from the first half of this century usually known as the Gnostic redeemer myth. This was the thesis, associated particularly with the name of R. Bultmann, that already in the pre-Christian period there was a widely held belief in a divine figure who came down from heaven and assumed human form in order to redeem the souls of men trapped within human bodies. They will also be aware that while Bultmann's thesis has come under heavy attack and is not widely held today, there are those who still attempt to argue for it, though usually in a substantially modified form. My purpose in this paper is to draw attention to one of the side-effects of this whole debate, an important side-effect which has not been given the attention it deserves. For it is my belief that the quest of the Gnostic redeemer myth within pre-Christian traditions, and the debate thereby stirred up, havetogetherconfused the history of Christology' beginings, particularly in the key issue of Christ's relation with God. Although principally concerned with soteriology, the discussion roused by the hypothesis of the Gnostic redeemer myth has raised the question of Christianity'sthelogy(in the narrower sense of that term). In other words, it forces students of Christian origins to askwhether Christianity began as a departure from Jewish monotheism, whether Christianity was in fact a monotheistic faith from the beginning.

scholarly journals Midwakh (pipe) and seizure: The overlooked link

2021 ◽  
Vol 7 (2) ◽  
pp. 140-142
Author(s):  
Mustafa Mahmood Eid
Keyword(s):  
Young People ◽  
Side Effect ◽  
Case Presentation ◽  
Unwanted Side Effect ◽  
History Of ◽  
Previous Disease ◽  
Smoke Tobacco ◽  
Neurological System

Objective: Numerous drugs and medications from various pharmacological classes can lead to seizures as an unwanted side effect. Midwakh is a pipe commonly used to smoke tobacco blend in small quantities. Midwakh use is increasing, especially among young people. Case Presentation: A 17-year-old patient with a history of seizures was provoked by smoking midwakh, despite having no previous disease history. Conclusion: Although the patient had a negative workup for epilepsy, midwakh should be classified as an epileptogenic drug. More studies need to be conducted on the effects of midwakh on the neurological system.

scholarly journals Predicting the side effects of drugs using matrix factorization on spontaneous reporting database

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kohei Fukuto ◽  
Tatsuya Takagi ◽  
Yu-Shi Tian
Keyword(s):  
Side Effects ◽  
Matrix Factorization ◽  
Side Effect ◽  
Cold Start ◽  
Factorization Method ◽  
Mapping Method ◽  
Spontaneous Reports ◽  
The Matrix ◽  
History Of ◽  
Cold Start Problem

AbstractThe severe side effects of some drugs can threaten the lives of patients and financially jeopardize pharmaceutical companies. Computational methods utilizing chemical, biological, and phenotypic features have been used to address this problem by predicting the side effects. Among these methods, the matrix factorization method, which utilizes the side-effect history of different drugs, has yielded promising results. However, approaches that encapsulate all the characteristics of side-effect prediction have not been investigated to date. To address this gap, we applied the logistic matrix factorization algorithm to a database of spontaneous reports to construct a prediction with higher accuracy. We expressed the distinction in the importance of drug-side effect pairs by a weighting strategy and addressed the cold-start problem via an attribute-to-feature mapping method. Consequently, our proposed model improved the prediction accuracy by 2.5% and efficiently handled the cold-start problem. The proposed methodology is expected to benefit applications such as warning systems in clinical settings.

Cutaneous ulcers following hydroxyurea therapy

Phlebologie ◽  
2004 ◽  
Vol 33 (06) ◽  
pp. 202-205 ◽  
Author(s):  
K. Hartmann ◽  
S. Nagel ◽  
T. Erichsen ◽  
E. Rabe ◽  
K. H. Grips ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Antineoplastic Agent ◽  
Limited Time ◽  
Myeloproliferative Diseases ◽  
Dermatological Side Effects ◽  
Chronic Myeloproliferative Diseases ◽  
Hydroxyurea Therapy

SummaryHydroxyurea (HU) is usually a well tolerated antineoplastic agent and is commonly used in the treatment of chronic myeloproliferative diseases. Dermatological side effects are frequently seen in patients receiving longterm HU therapy. Cutaneous ulcers have been reported occasionally.We report on four patients with cutaneous ulcers whilst on long-term hydroxyurea therapy for myeloproliferative diseases. In all patients we were able to reduce the dose, or stop HU altogether and their ulcers markedly improved. Our observations suggest that cutaneous ulcers should be considered as possible side effect of long-term HU therapy and healing of the ulcers can be achieved not only by cessation of the HU treatment, but also by reducing the dose of hydroxyurea for a limited time.

Probiotics in gastroenterology – from a different angle

2013 ◽  
Vol 154 (8) ◽  
pp. 294-304 ◽  
Author(s):  
György Miklós Buzás
Keyword(s):  
Side Effects ◽  
Beneficial Effect ◽  
Analytical Data ◽  
Well Being ◽  
Gastrointestinal Diseases ◽  
Convincing Evidence ◽  
Probiotic Treatment ◽  
History Of ◽  
Irritable Bowel

After a short overview of the history of probiotics, the author presents the development of human intestinal microflora based on the newest genetic data and the microbiological features of main probiotics. The indications of probiotic administration have been defined and extended in recent years. The author reviews significant results of probiotic treatment in some gastrointestinal diseases based on meta-analytical data. Probiotics are useful in preventing and treating diarrhoea caused by antibiotics and Clostridium difficile caused diarrhoea. In the treatment of Helicobacter pylori infection, preparations containing certain Lactobacillus,Bifidobacterium strains or Saccaromyces boulardii could enhance by 5–10% the rate of successful eradication and reduce the incidence and severity of the side effects. Some symptoms of irritable bowel syndrome and thus the quality of life can be improved by probiotics. Their beneficial effect in ulcerative colitis was proven, while in Crohn’s disease has not yet been defined. The use of probiotics is not included in guidelines, with the exception of the Maastricht IV/Florence consensus. For each disease it is advisable to use probiotics containing strains only with proven beneficial effect. The efficiency of preparations containing mixed strains has not yet been properly investigated. The author reviews the rare but potentially serious side effects of probiotics. In Hungary, there are many probiotic preparations available which can be purchased in pharmacies without prescription: their use is more empirical than evidence-based. The European Food Safety Authority has recently rejected claims for probiotics to be classed as medicines given the lack of convincing evidence on the effects of probiotics on human health and well-being. Clearly, further research is needed to collect evidence which could be incorporated into the international guidelines. Orv. Hetil., 2013, 154, 294–304.

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