Chlamydia trachomatis infection and non-gonococcal urethritis in homosexual and heterosexual men in Edinburgh

2002 ◽  
Vol 13 (6) ◽  
pp. 425-426 ◽  
Author(s):  
L Dixon ◽  
S Pearson ◽  
D J Clutterbuck
Keyword(s):  
Chlamydia Trachomatis ◽  
Chlamydial Infection ◽  
Heterosexual Men ◽  
Homosexual Men ◽  
Chain Reaction ◽  
Routine Testing ◽  
Chlamydia Trachomatis Infection ◽  
Gonococcal Urethritis ◽  
The Usa ◽  
And Bisexual

In 1998, when ligase chain reaction testing for chlamydial infection was introduced in our clinic in Edinburgh, routine clinic protocol included the testing of all heterosexual, but not homosexual, men for urethral chlamydial infection. We audited all new homosexual and bisexual male attendees with a diagnosis of chlamydial infection or non-gonococcal urethritis (NGU) in 1999, together with heterosexual men with the same diagnoses attending in alternate months of the same year. Urethral Chlamydia trachomatis infection was detected in 14.6% (350/2402) of heterosexual men and 2.4% (11/465) of homosexual men tested. Fifty percent of chlamydial infections were asymptomatic. In this population 44% (84/190) of NGU in heterosexual men is attributable to C. trachomatis as opposed to only 10% (6/59) of that in homosexual men. These rates of chlamydial infection differ from previous reports in Scotland and recent studies from the USA. Our clinic protocol has been revised to include routine testing for chlamydial infection in all men.

Chlamydia Trachomatis Infection of the Cervix: The Need for a Diagnostic Service

1982 ◽  
Vol 27 (2) ◽  
pp. 147-151 ◽  
Author(s):  
Jennifer M. Hunter ◽  
Isabel W. Smith ◽  
J. F. Peutherer ◽  
A. J. MacAulay
Keyword(s):  
Chlamydia Trachomatis ◽  
Chlamydial Infection ◽  
Screening Service ◽  
Chlamydia Trachomatis Infection ◽  
High Isolation ◽  
Diagnostic Service ◽  
Cervical Infection ◽  
Gonococcal Urethritis ◽  
Symptom Complex

Chlamydia trachomatis was isolated from the cervix in 20.4 per cent (104/511) of women attending a department of genito-urinary medicine. Isolation rates ranged from 43.3 per cent in women with gonorrhoea to 4.2 per cent in women with no STD and who required no treatment. There was no association between the presence of chlamydia in the cervix and any symptom complex. Although high isolation rates were also noted in women with signs of cervicitis and in women whose partners had non-gonococcal urethritis, the accuracy of such clinical and epidemiological criteria in predicting cervical infection was low. In the absence of a screening service the chlamydial infection of 81 women (those who were not NGU contacts) would have been undiagnosed and untreated. The need for a screening service is discussed.

scholarly journals Comparison of the ligase chain reaction with cell culture for the diagnosis of Chlamydia trachomatis infection in women.

1996 ◽  
Vol 49 (2) ◽  
pp. 116-119 ◽  
Author(s):  
G L Ridgway ◽  
G Mumtaz ◽  
A J Robinson ◽  
M Franchini ◽  
C Carder ◽  
...  
Keyword(s):  
Cell Culture ◽  
Chlamydia Trachomatis ◽  
Chain Reaction ◽  
Ligase Chain Reaction ◽  
Chlamydia Trachomatis Infection

Non-chlamydial non-gonococcal urethritis or undiagnosed chlamydial urethritis?

2006 ◽  
Vol 17 (5) ◽  
pp. 296-298 ◽  
Author(s):  
K Manavi ◽  
A McMillan ◽  
H Young
Keyword(s):  
Chlamydial Infection ◽  
False Negative ◽  
Culture Method ◽  
Sexual Partners ◽  
Chain Reaction ◽  
Sexually Transmitted ◽  
Female Partners ◽  
Gonococcal Urethritis ◽  
Negative Results ◽  
False Negative Results

The aim of this study is to investigate the prevalence of sexually transmitted infections (STI) in the partners of men with non-chlamydial, non-gonococcal urethritis (NCNGU). Observational study of the sexual partners of men with NCNGU diagnosed in the Department of Genitourinary Medicine, Edinburgh between 1 June 2002 and 31 December 2003. The diagnosis of chlamydial infection was based on ligase chain reaction (LCx) between June 2002 and March 2003, and on polymerase chain reaction (PCR) thereafter. Gonococcal infection was diagnosed with culture method. Sexual partners of 99 (25%) of the 403 heterosexual men diagnosed with NCNGU were screened. Chlamydial infection was detected in 19 (19%) of the female sexual partners. Higher proportion of female partners of symptomatic men (15/51) had chlamydial infection compared with that of partners of asymptomatic men (4/48) ( P < 0.005). NCNGU may be related to false-negative results of chlamydial diagnostic tests. Screening and treatment of sexual partners of men with NCNGU is therefore necessary.

scholarly journals Prevalence of Chlamydia trachomatis infection diagnosed by polymerase chain reaction in female sex workers in a Northern Mexican City

2019 ◽  
Vol 9 (1) ◽  
pp. 5-8
Author(s):  
Luis Francisco Sánchez-Anguiano ◽  
Nadia Velázquez-Hernández ◽  
Fernando Martín Guerra-Infante ◽  
Marisela Aguilar-Durán ◽  
Alma Rosa Pérez-Álamos ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Chlamydia Trachomatis ◽  
Sex Workers ◽  
Female Sex Workers ◽  
Chain Reaction ◽  
Chlamydia Trachomatis Infection ◽  
Female Sex ◽  
Polymerase Chain

Concurrent gonococcal and chlamydial infections among men attending a sexually transmitted diseases clinic

2005 ◽  
Vol 16 (5) ◽  
pp. 357-361 ◽  
Author(s):  
A McMillan ◽  
K Manavi ◽  
H Young
Keyword(s):  
Retrospective Study ◽  
Chlamydia Trachomatis ◽  
Confidence Interval ◽  
Sexually Transmitted Diseases ◽  
Chlamydial Infection ◽  
Empirical Treatment ◽  
Heterosexual Men ◽  
Sexually Transmitted ◽  
High Prevalence ◽  
Sex With Men

The aim of this retrospective study was to determine the prevalence of Chlamydia trachomatis co-infection in men with gonorrhoea attending a sexually transmitted diseases clinic in Edinburgh, Scotland. During the study period, there were 660 cases of culture-proven gonorrhoea. Chlamydial DNA was detected in the urethra in 79 (31%; 95% confidence interval [CI], 25–37%) heterosexual men who have sex with women (MSW); the median age was significantly lower than those with gonorrhoea alone (24.0 versus 30.0; P < 0.0005). The prevalence of urethral chlamydial infection among MSW was significantly higher than among men who have sex with men (MSM) (32 [12%; 95% CI, 8–16%] of 268 MSM) (χ2 = 27.21; P < 0.001). Sixteen (24%; 95% CI, 14–34%) of 68 MSM with rectal gonorrhoea had concurrent rectal chlamydial infection. The high prevalence of concurrent gonorrhoea and chlamydiae therefore warrants empirical treatment and/or testing for chlamydia in all men with urethral gonorrhoea.

Prevalence of Mycoplasma genitalium in men with gonococcal urethritis

1996 ◽  
Vol 7 (6) ◽  
pp. 443-444 ◽  
Author(s):  
M Uno ◽  
T Deguchi ◽  
H Komeda ◽  
M Yasuda ◽  
M Tamaki ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Chlamydia Trachomatis ◽  
Enzyme Immunoassay ◽  
Mycoplasma Genitalium ◽  
Chain Reaction ◽  
Gonococcal Urethritis ◽  
Japanese Male ◽  
Male Patients ◽  
Polymerase Chain

A significant association of Mycoplasma genitalium with non-gonococcal urethritis has been reported, but the prevalence of this mycoplasma in men with gonococcal urethritis has not been so well studied. In this study, we examined urethral swab specimens from 45 Japanese male patients with gonococcal urethritis for the presence of M. genitalium by using a polymerase chain reaction-based assay. We also sought Chlamydia trachomatis by an enzyme immunoassay Chlamydiazyme . Of the 45 specimens, 2 4.4 were positive for the mycoplasma and 12 26.7 were positive for C. trachomatis. The findings suggest that M. genitalium may be a cause not only of non-gonococcal urethritis but also of postgonococcal urethritis.

scholarly journals Comparison of Performances of Two Commercially Available Tests, a PCR Assay and a Ligase Chain Reaction Test, in Detection of Urogenital Chlamydia trachomatis Infection

1998 ◽  
Vol 36 (6) ◽  
pp. 1489-1493 ◽  
Author(s):  
Mirja Puolakkainen ◽  
Eija Hiltunen-Back ◽  
Timo Reunala ◽  
Satu Suhonen ◽  
Pekka Lähteenmäki ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Clinical Laboratory ◽  
Transmitted Disease ◽  
Chain Reaction ◽  
Ligase Chain Reaction ◽  
Chlamydia Trachomatis Infection ◽  
Sexually Transmitted ◽  
Transport Medium ◽  
Sexually Transmitted Disease Clinic ◽  
Chain Reaction Test

The diagnostic performance of a PCR test (Roche Cobas Amplicor CT/NG Test) and that of a ligase chain reaction (LCR) test (Abbott LCxChlamydia trachomatis assay) were compared by using endocervical and urethral swab specimen culture as a reference test. First-void urine (FVU) and endocervical and urethral swab specimens were collected from 1,015 unselected patients attending a sexually transmitted disease clinic and a clinic for adolescents in Helsinki, Finland. Chlamydia trachomatis was cultured from samples from the endocervix or urethra. PCR was performed with fresh and frozen urine and the culture transport medium. LCR was performed with fresh and frozen urine and LCx swab transport medium. Diagnostic consistency and diagnostic accuracy were statistically tested. The test results were identical for 984 patients (97%). Discrepant results were observed for 31 patients. Overall, LCR and PCR showed excellent kappa coefficients of consistency for both swab and FVU specimens (0.93 and 0.95, respectively). Sixty-one patients (6%) were culture positive. Testing of FVU by LCR or PCR increased the overall positivity rates to 7.0 and 7.7%, respectively. While PCR of FVU detected the greatest number of C. trachomatis infections (sensitivity, 96.1%), for some PCR-positive FVU specimens the results could not be confirmed (specificity, 99.6%). PCR and LCR were more sensitive than culture (sensitivities, 92 and 93% versus 79% for culture) in the diagnosis of genital C. trachomatis infection. In conclusion, both tests can be recommended for use in the clinical laboratory and for the screening of asymptomatic C. trachomatis infections.

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