Unilateral leg swelling: deep vein thrombosis?

Objective We present two cases of a unilateral leg swelling of unusual aetiology as a reminder to the physician to consider causes of unilateral leg swelling other than deep vein thrombosis, lymphoedema and infectious diseases. Case reports Both of our patients developed progressive leg swelling. Subsequent investigation revealed a lesion compressing the femoral vein. At exploration this was found to be a ganglion cyst. In one patient surgical removal of the cyst and in the other puncture of the cyst and instillation of steroid resulted in prompt resolution of the swelling. Conclusion Venous compression due to external cystic lesions, although rare, is recognized. In strange cases this differential diagnosis should also be taken into account. Therapeutic options are the surgical removal or puncture of the cyst.

Download Full-text

Catheter Directed Thrombolysis for Deep Vein Thrombosis during the First Trimester of Pregnancy: Two Case Reports

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2008.58.2.127 ◽

2008 ◽

Vol 58 (2) ◽

pp. 127

Author(s):

Kum Rae Kim ◽

Won Kyu Park ◽

Jae Woon Kim ◽

Woo Hyung Kwun ◽

Bo Yang Suh ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Case Reports ◽

First Trimester ◽

Vein Thrombosis ◽

Catheter Directed Thrombolysis ◽

First Trimester Of Pregnancy ◽

Deep Vein

Download Full-text

Chronic lower extremity deep vein thrombosis associated with femoral vein compression by a lipoma.

American Journal of Roentgenology ◽

10.2214/ajr.172.6.10350325 ◽

1999 ◽

Vol 172 (6) ◽

pp. 1697-1698 ◽

Cited By ~ 5

Author(s):

P S Brady ◽

L D Spence

Keyword(s):

Deep Vein Thrombosis ◽

Lower Extremity ◽

Femoral Vein ◽

Vein Thrombosis ◽

Deep Vein

Download Full-text

A murine model of deep vein thrombosis Characterization and validation in transgenic mice

Thrombosis and Haemostasis ◽

10.1160/th05-03-0170 ◽

2005 ◽

Vol 94 (09) ◽

pp. 498-503 ◽

Cited By ~ 25

Author(s):

Linda Szema ◽

Chao-Ying Chen ◽

Jeffrey P. Schwab ◽

Gregory Schmeling ◽

Brian C. Cooley

Keyword(s):

Deep Vein Thrombosis ◽

Murine Model ◽

Femoral Vein ◽

Previous History ◽

Bed Rest ◽

Major Surgery ◽

Vein Thrombosis ◽

Transgenic Lines ◽

History Of ◽

Deep Vein

SummaryDeep vein thrombosis (DVT) occurs with high prevalence in association with a number of risk factors, including major surgery, trauma, obesity, bed rest (>5 days), cancer, a previous history of DVT, and several predisposing prothrombotic mutations. A novel murine model of DVT was developed for applications to preclinical studies of transgenically constructed prothrombotic lines and evaluation of new antithrombotic therapies. A transient direct-current electrical injury was induced in the common femoral vein of adult C57Bl/6 mice. A non-occlusive thrombus grew, peaking in size at 30 min, and regressing by 60 min, as revealed by histomorphometric volume reconstruction of the clot. Pre-heparinization greatly reduced clot formation at 10, 30, and 60 min (p<0.01 versus non-heparinized). Homozygous FactorV Leiden mice (analogous to the clinical FactorV Leiden prothrombotic mutation) on a C57Bl/6 background had clot volumes more than twice those of wild-types at 30 min (0.121±0.018 mm3 vs. 0.052±0.008 mm3, respectively; p<0.01). Scanning electron microscopy revealed a clot surface dominated by fibrin strands, in contrast to arterial thrombi which showed a platelet-dominated structure. This new model of DVT presents a quantifiable approach for evaluating thrombosis-related murine transgenic lines and for comparatively evaluating new pharmacologic approaches for prevention of DVT.

Download Full-text

TCTAP C-223 Catheter-directed Thrombolysis, Iliac and Common Femoral Vein Stenting in May-thurner Syndrome with Refractory Deep Vein Thrombosis

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2016.03.438 ◽

2016 ◽

Vol 67 (16) ◽

pp. S373-S374

Author(s):

Chiung-Ray Lu ◽

Ke Wei Chen

Keyword(s):

Deep Vein Thrombosis ◽

Femoral Vein ◽

Common Femoral Vein ◽

Vein Thrombosis ◽

Catheter Directed Thrombolysis ◽

Deep Vein

Download Full-text

Advantages of a Sequential Compression Device in Prevention of Deep Vein Thrombosis

10.1055/s-0039-1684785 ◽

1979 ◽

Author(s):

A.N. Nicolaides ◽

J. Fernandas ◽

A.V. Pollock

Keyword(s):

Deep Vein Thrombosis ◽

Femoral Vein ◽

Test Group ◽

Heparin Group ◽

Similar Time ◽

Vein Thrombosis ◽

Compression Device ◽

Fibrinogen Test ◽

Group B ◽

Deep Vein

A sequential compression device (SCD) (6 chambers) compressing the ankle, calf end thigh sequentially at 35, 30 and 20 mm Hg for 12 seconds in every minute produced a 240% increase in peak velocity in the femoral vein. A non-sequential device (NSD) inflated to 25 mm Hg with a similar time cycle produced only an 180% increase in blood velocity.The two devices were tested clinically; 250 surgical patients were randomised to 3 groups scanned with the 125 I-fibrinogen test. Group A: 7 days subcutaneous heparin. Group B: NSD for 24 hours. Group C: SCD for 24 hours. The SCD was found to be as effective as heparin during the period it was used and more effective than NSD in preventing deep vein thrombosis proximal to the calf.

Download Full-text