scholarly journals Positron emission tomography/MRI for cardiac diseases assessment

2020 ◽  
Vol 93 (1113) ◽  
pp. 20190836 ◽  
Author(s):  
Osamu Manabe ◽  
Noriko Oyama-Manabe ◽  
Nagara Tamaki
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Current Evidence ◽  
Functional Evaluation ◽  
Clinical Practices ◽  
Positron Emission ◽  
Pet Ct ◽  
Magnetic Resonance Imaging Mri ◽  
Effective Integration

Functional imaging tools have emerged in the last few decades and are increasingly used to assess the function of the human heart in vivo. Positron emission tomography (PET) is used to evaluate myocardial metabolism and blood flow. Magnetic resonance imaging (MRI) is an essential tool for morphological and functional evaluation of the heart. In cardiology, PET is successfully combined with CT for hybrid cardiac imaging. The effective integration of two imaging modalities allows simultaneous data acquisition combining functional, structural and molecular imaging. After PET/CT has been successfully accepted for clinical practices, hybrid PET/MRI is launched. This review elaborates the current evidence of PET/MRI in cardiovascular imaging and its expected clinical applications for a comprehensive assessment of cardiovascular diseases while highlighting the advantages and limitations of this hybrid imaging approach.

Biomaterials in repairing rat femoral defects: In vivo insights from small animal positron emission tomography/computed tomography (PET/CT) studies

2019 ◽  
Vol 73 (1) ◽  
pp. 177-194 ◽  
Author(s):  
Christin Neuber ◽  
Sabine Schulze ◽  
Yvonne Förster ◽  
Frank Hofheinz ◽  
Johanna Wodke ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Small Animal ◽  
Emission Tomography ◽  
Positron Emission ◽  
Pet Ct ◽  
Ct Studies

Utilidad de la tomografía por emisión de positrones/tomografía computada (PET/CT) en pacientes con diagnóstico de meduloblastoma

2020 ◽  
Vol 63 (1) ◽  
pp. 34-41
Author(s):  
Rocío Elizabeth García Dávila ◽  
Sergio Díaz Bello ◽  
Raúl Villanueva Rodríguez ◽  
René López León ◽  
Luis Valencia Vázquez
Keyword(s):  
Positron Emission Tomography ◽  
Central Nervous System ◽  
Nervous System ◽  
Somatostatin Receptors ◽  
Emission Tomography ◽  
Imaging Method ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg

"PET/CT (positron emission tomography/computed tomography, for its acronym in English) is a unique imaging method that provides in vivo evidence of both biochemical and physiological activities of the brain, spinal cord and tumors that involve these structures. Medulloblastoma is the most common malignant tumor of the central nervous system (CNS) in pediatric patients, so PET/CT plays an important role as it provides information on the grade and extent of the tumor as well as to determine the appropriate site for the biopsy, assessing the response to the treatment and the patient’s prognosis. There are different radiopharmaceuticals for the evaluation of central nervous system tumors, but 18F FDG (Fluor-2-fluoro-2-desoxy-D-glucose) and 68Ga-DOTA-NOC (68Ga-DOTA0-1NaI3-octreotide) have been studied to help us evaluate and follow up patients diagnosed with medulloblastoma. Medulloblastoma has an overexpression of glucose transporters, mainly type 1, and an overexpression of predominantly type 2 somatostatin receptors, which allows a high affinity for these radiopharmaceuticals. Key words: Medulloblastoma; positron emission tomography; PET/C; 18F-FDG; 68Ga-DOTA-NOC; brain tumor.

scholarly journals The “Undetermined Significance” of 18F-FDG PET/CT or PET/MRI in Patients with Monoclonal Gammopathy of Undetermined Significance (MGUS)

Medicina ◽  
2021 ◽  
Vol 57 (8) ◽  
pp. 856
Author(s):  
Giorgio Treglia ◽  
Francesco Bertagna ◽  
Domenico Albano
Keyword(s):  
Positron Emission Tomography ◽  
Fdg Pet ◽  
Monoclonal Gammopathy ◽  
Emission Tomography ◽  
Current Evidence ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Undetermined Significance

Monoclonal gammopathy of undetermined significance (MGUS) is a highly prevalent condition with the possible risk of progression to multiple myeloma (MM) or a lymphoproliferative neoplasm in a small percentage of patients. Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) or positron emission tomography/magnetic resonance imaging (PET/MRI) are imaging methods increasingly used in patients with MM. The aim of this communication is to underline that, taking into account current evidence-based data, compared to MM the role of 18F-FDG PET/CT or PET/MRI in MGUS is still undetermined and more studies should be performed before suggesting 18F-FDG PET/CT or PET/MRI for evaluation of MM progression in patients with MGUS.

scholarly journals A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Nanoscale ◽  
2019 ◽  
Vol 11 (28) ◽  
pp. 13243-13248 ◽  
Author(s):  
Arnab Banerjee ◽  
Vitor Alves ◽  
Tiago Rondão ◽  
José Sereno ◽  
Ângela Neves ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Receptor Proteins ◽  
Positron Emission ◽  
Surface Receptor ◽  
Magnetic Resonance Imaging Mri

A new radiolabeling strategy which did not change the morphology, surface receptor proteins and internal RNA content of SEVs used for PET/MRI imaging and detection of their location in brain.

scholarly journals Positron Emission Tomography in the Study of Brain Metabolism in Psychiatric and Neuropsychiatric Disorders

1990 ◽  
Vol 157 (S9) ◽  
pp. 82-95 ◽  
Author(s):  
C. J. Bench ◽  
R. J. Dolan ◽  
K. J. Friston ◽  
R. S. J. Frackowiak
Keyword(s):  
Positron Emission Tomography ◽  
Brain Function ◽  
Brain Metabolism ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Computerised Tomography ◽  
Basic Principles ◽  
Positron Emission ◽  
Magnetic Resonance Imaging Mri

Positron emission tomography (PET) differs fundamentally from computerised tomography (CT) and magnetic resonance imaging (MRI) in that it is a method for measuring function as opposed to structure. It is the most powerful tool available for the measurement of in-vivo brain function. This review describes the basic principles of the technique and its application to the study of brain metabolism in neurological and psychiatric disorder. The development of resting-state metabolic studies by the application of specific activation paradigms, a major current focus of the technique, is discussed.

scholarly journals Comparison of In vivo [18F]Fluoro-desoxyglucose and [18F]Fluoro-thymidine Positron Emission Tomography for Disease Monitoring in a Mouse Model of Higher-Risk Myelodysplastic Syndrome

2021 ◽  
Author(s):  
Laure Sarda-Mantel ◽  
Panhong Gou ◽  
Fortune Hontonnou ◽  
Benoit Hosten ◽  
Nicolas Vignal ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Bone Marrow ◽  
Mouse Model ◽  
Myelodysplastic Syndrome ◽  
Hot Spots ◽  
Emission Tomography ◽  
Flt Pet ◽  
Positron Emission ◽  
Pet Ct

Higher-risk myelodysplastic syndrome (HR-MDS) has a poor prognosis in the absence of efficient therapy. The evaluation of new therapies in animal models of HR-MDS is hampered by the absence of accurate in vivo biomarkers of the disease. In this study we compared [18F]Fluoro-desoxyglucose Positron Emission Tomography (FDG-PET) and [18F]Fluoro-thymidine (FLT)-PET imaging for disease follow-up in a triple transgenic MMTVtTA/TetoBCL-2/MRP8NRASD12 mouse model of HR-MDS. Normal control FVB/N mice (G1,n=9) and HR-MDS mice (G2,n=12) underwent both FDG- and FLT-PET procedures at 2-day intervals, on a dedicated small animal device. Blood cell counting, BCL-2 and Mac-1hi/Gr-1lo expression measurements in blood were performed before each PET procedure. Visually, PET images of G2 mice demonstrated homogeneous FDG uptake in the whole skeleton similar to that observed in G1 mice, and abnormal FLT hot spots in bone marrow not observed in G1 mice. The intensity of FLT hot spots in bone marrow was higher in 3-months old G2 mice than in 2-months old G2 mice, concordant with a higher percentage of cells expressing Mac-1hi/Gr-1lo and lower platelets counts. We conclude that FLT-PET/CT imaging is a more valuable surrogate non-invasive quantitative marker of HR-MDS bone marrow involvement than FDG-PET/CT in our mouse model of HR-MDS.

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