Abstract
Background While increased expression of soluble CD121a (Interleukin 1 Receptor Type 1, IL-1R1) has been shown to be significantly correlated with the severity of coronary artery disease (CAD), it is not yet clear whether IL-1R1 gene variants impact CAD pathogenesis. Methods The present study evaluated the effects of IL-1R1 variants on CAD in a Chinese-Han population; A two-stage case-control study assessed 928 Chinese-Han patients via coronary arteriography for coronary atherosclerosis. The allele and genotype frequencies of the analyzed IL-1R1 polymorphisms were determined via a polymerase chain reaction assay and directly sequenced. Results The IL-1R1 variant rs2234651 was found to be associated with both CAD risk and severity (the degree of exhibited vascular stenosis/number of affected vessels, P = 0.034; Gensini scoring, P = 0.006). Furthermore, significant increase of IL-8 and IL-11 in patients carrying the CT+TT genotype was observed. Finally, serum CD121a levels significantly increased in patients with CAD that harbored the CT+TT genotype ( P <0.05). Conclusions These results demonstrate that the IL-1R1 variant rs2234651 is significantly associated with CAD risk and severity in the analyzed Chinese-Han population and rs2234651 may be a valuable target for CAD prevention and/or treatment.
Promoter Polymorphism of Toll-Like Receptor 4 is Associated with a Decreased Risk of Coronary Artery Disease: A Case-Control Study in the Chinese Han Population