scholarly journals Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study

2012 ◽  
Vol 11 (1) ◽  
pp. 128 ◽  
Author(s):  
Xiaofei Lv ◽  
Yuan Zhang ◽  
Shaoqi Rao ◽  
Fengqiong Liu ◽  
Xiaoyu Zuo ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Cluster ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Artery Disease ◽  
Control Study

scholarly journals ACAT-1 gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a case-control study

Oncotarget ◽  
2017 ◽  
Vol 8 (51) ◽  
pp. 89055-89063 ◽  
Author(s):  
Yong-Tao Wang ◽  
Ying-Hong Wang ◽  
Yi-Tong Ma ◽  
Zhen-Yan Fu ◽  
Yi-Ning Yang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han ◽  
Han Population ◽  
Artery Disease ◽  
Control Study ◽  
Increased Susceptibility

scholarly journals PARP-1 Variant Rs1136410 Confers Protection against Coronary Artery Disease in a Chinese Han Population: A Two-Stage Case-Control Study Involving 5643 Subjects

2017 ◽  
Vol 8 ◽  
Author(s):  
Xue-bin Wang ◽  
Ning-hua Cui ◽  
Shuai Zhang ◽  
Shu-ren Guo ◽  
Ze-jin Liu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han ◽  
Two Stage ◽  
Han Population ◽  
Artery Disease ◽  
Parp 1 ◽  
Control Study

scholarly journals The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

2020 ◽  
Author(s):  
Jiayi Gu ◽  
Ping Zhou ◽  
Yongyue Wei ◽  
Wei Gao ◽  
Yujiao Yang ◽  
...  
Keyword(s):  
Case Control Study ◽  
Interleukin 1 ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Artery Disease ◽  
Cad Risk ◽  
Control Study

Abstract Background While increased expression of soluble CD121a (Interleukin 1 Receptor Type 1, IL-1R1) has been shown to be significantly correlated with the severity of coronary artery disease (CAD), it is not yet clear whether IL-1R1 gene variants impact CAD pathogenesis. Methods The present study evaluated the effects of IL-1R1 variants on CAD in a Chinese-Han population; A two-stage case-control study assessed 928 Chinese-Han patients via coronary arteriography for coronary atherosclerosis. The allele and genotype frequencies of the analyzed IL-1R1 polymorphisms were determined via a polymerase chain reaction assay and directly sequenced. Results The IL-1R1 variant rs2234651 was found to be associated with both CAD risk and severity (the degree of exhibited vascular stenosis/number of affected vessels, P = 0.034; Gensini scoring, P = 0.006). Furthermore, significant increase of IL-8 and IL-11 in patients carrying the CT+TT genotype was observed. Finally, serum CD121a levels significantly increased in patients with CAD that harbored the CT+TT genotype ( P <0.05). Conclusions These results demonstrate that the IL-1R1 variant rs2234651 is significantly associated with CAD risk and severity in the analyzed Chinese-Han population and rs2234651 may be a valuable target for CAD prevention and/or treatment.

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