Monitoring the Changes of Upper Limb Water in Breast Cancer Patients by Segmental Multi-Frequency Bioelectrical Impedance Analysis

Background: The surgical treatments of breast cancer associated or not with axillary drainage and radiotherapy constitute the main cause of secondary upper limb lymphedema. Obesity is a particularly aggravating aspect in patients with lymphedema. Novel concepts of subclinical systemic lymphedeman and clinical systemic lymphedema have recently been described. The aim of the present study was to evaluate the evolution of subclinical systemic lymphedema to upper limb lymphedema following treatment for breast cancer. Case: A 36-year-old female patient had been submitted to treatment for breast cancer involving left-side mastectomy and lymph node drainage during a pregnancy three years earlier. She had undergone both chemotherapy and radiotherapy. The patient had a portacath in the right arm for chemotherapy, which was removed after the first evaluation. She was submitted to bioelectrical impedance analysis, which revealed an increase in intracellular and extracellular water and body water in all limbs and the trunk above the normal range. The patient returned approximately two years after the initial evaluation, complaining of edema in the left arm. Conclusion: The treatment of breast cancer in patients with lipedema could lead to the development of subclinical lymphedema in patients with a BMI less than 30 kg/m2. Therefore, such conditions constitute a warning sign for the development of lymphedema.

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3053 POSTER Venous Thrombosis Rates in Early Breast Cancer Patients Receiving Standard Chemotherapy, a Retrospective Analysis. Investigation and Treatment of Upper Limb Symptoms

European Journal of Cancer ◽

10.1016/s0959-8049(11)71126-1 ◽

2011 ◽

Vol 47 ◽

pp. S238

Author(s):

J. Kahan ◽

O. Oikonomidou ◽

N. Greenwood ◽

T. Marler-Hausen ◽

A. Rigg

Keyword(s):

Breast Cancer ◽

Venous Thrombosis ◽

Retrospective Analysis ◽

Cancer Patients ◽

Early Breast Cancer ◽

Upper Limb ◽

Breast Cancer Patients ◽

Standard Chemotherapy

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THE ASSESSMENT OF HYDRATION IN ADVANCED CANCER PATIENTS USING BIOELECTRICAL IMPEDANCE ANALYSIS

BMJ Supportive & Palliative Care ◽

10.1136/bmjspcare-2014-000654.8 ◽

2014 ◽

Vol 4 (Suppl 1) ◽

pp. A3.2-A3 ◽

Cited By ~ 1

Author(s):

Amara Nwosu ◽

Catriona Mayland ◽

Andrea Varro ◽

John Ellershaw

Keyword(s):

Cancer Patients ◽

Advanced Cancer ◽

Bioelectrical Impedance Analysis ◽

Bioelectrical Impedance ◽

Impedance Analysis ◽

Advanced Cancer Patients

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Prospective metrological validation of multifrequency bioelectrical impedance analysis against volumetric imaging to identify sarcopenia in head and neck cancer patients undergoing radiation therapy

10.1101/19006668 ◽

2019 ◽

Author(s):

Aaron J. Grossberg ◽

Crosby D. Rock ◽

Jared Edwards ◽

Abdallah S.R. Mohamed ◽

Debra Ruzensky ◽

...

Keyword(s):

Body Composition ◽

Radiation Therapy ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Body Mass ◽

Neck Cancer ◽

Bioelectrical Impedance Analysis ◽

Bioelectrical Impedance ◽

Impedance Analysis

AbstractImportanceDepleted skeletal muscle mass (sarcopenia) is associated with decreased survival and cancer control in head and neck cancer patients treated with radiotherapy. There is a need for validated measures of body composition that can be implemented in routine clinical workflow.ObjectiveTo validate the use of bioelectrical impedance analysis (BIA) for body composition analysis and diagnosis of sarcopenia in head and neck cancer patients.DesignIn this prospective observational cohort study, baseline 50 patients with head and neck cancer undergoing radiation therapy (RT) were enrolled between February 2016 and March 2017. Baseline BIA measures of skeletal muscle (SM) mass, fat-free mass (FMM), and fat mass (FM) were compared to CT-based estimates of body composition using linear regression. Sex-specific BIA-derived thresholds for sarcopenia were defined by the maximum Youden Index on receiver operator characteristic (ROC) curves of BIA against CT-defined sarcopenia. Changes in body composition across treatment were compared against changes in body weight using linear regression.ParticipantsIn total, 50 patients with pathologically confirmed stage I to IVB non-metastatic head and neck cancer treated with definitive radiation therapy were enrolled.SettingSingle academic referral center.Main Outcome and MeasureThe primary outcome was relative agreement between baseline lean body mass and fat body mass predicted from BIA measurement and CT imaging.ResultsOf the 48 evaluable patients 16 (33.3%) were sarcopenic at baseline based on CT analysis. BIA measures of body composition were strongly correlated with CT measures: SM mass (r = 0.97; R2 = 0.94; p < 0.0001), FFM (r = 0.97; R2 = 0.94; p < 0.0001) and FM (r = 0.95; R2 = 0.90; p < 0.0001). Relationship with normalized indices of SM mass, FFM, and FM was similar between BIA and CT, but not BIA and body mass index (BMI). Patients lost a mean of 5.7 ± 5.8 kg during treatment, of which 1.5 ± 1.9 kg was SM, 2.6 ± 3.3 kg was FFM, and 2.2 ± 2.6 kg was FM. Eight additional patients developed sarcopenia by the end of RT.ConclusionsBIA provides accurate estimates of body composition in head and neck cancer patients. Implementation of BIA in clinical practice may identify patients with sarcopenia.Trial RegistrationClinicalTrials.gov identifier: NCT02615275

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Upper limb lymphedema related to breast cancer therapy: incidence, risk factors, diagnostic techniques, risk reduction and optimal management

International Surgery Journal ◽

10.18203/2349-2902.isj20184636 ◽

2018 ◽

Vol 5 (11) ◽

pp. 3633

Author(s):

Hatem A. Saleh ◽

Tarek M. Rageh ◽

Suzan A. Alhassanin ◽

Mohamed A. Megahed

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Cancer Patients ◽

Upper Limb ◽

Diagnostic Techniques ◽

Breast Cancer Patients ◽

Breast Cancer Therapy ◽

Cancer Management ◽

Breast Cancer Management ◽

Incidence Risk

Background: Lymphedema remains to be a great source of morbidity for breast cancer survivors. The aim of this work is to study upper limb lymphedema following breast cancer therapy for breast cancer patients regarding its incidence, risk factors, diagnostic techniques, risk reduction and optimal management.Methods: This prospective study was done on two hundred breast cancer patients who underwent breast cancer management. The study was done in the period between May 2016 and July 2018. Exclusion criteria were Male patients, Female patients with metastatic breast cancer and who already had upper limb lymphedema before breast cancer management. All patients underwent follow up for incidence, risk factors, diagnostic techniques and management of lymphedema. Statistical analysis used: The collected data were organized, tabulated and statistically analyzed using SPSS softwareResults: The incidence of lymphedema was (18 %) distributed as follow: grade I = 55.6%, grade II = 33.3%, grade III = 11.1 % and grade IV = 0 %. The most relevant risk factors for development of lymphedema were: age between 41 and 50 years and diabetes mellitus. Higher incidence of pain (66.7%) and restricted motion (61.1%) were observed in lymphedema cases.Conclusions: Old (41:50 years) and diabetic patients are at the highest risk for developing lymphedema. Breast cancer patients of stage IIIB who had undergone modified radical mastectomy or who developed postoperative seroma are at higher risk for developing lymphedema. Physical exercises and compression garment are important part of treatment plan.

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