scholarly journals Clinical efficacy of phentolamine in the treatment of feeding intolerance in premature infants with low birth weight

2020 ◽  
Vol 36 (7) ◽  
Author(s):  
Hongya Li ◽  
Bin Li ◽  
Xuehua Wen
Keyword(s):  
Birth Weight ◽  
Length Of Stay ◽  
Low Birth Weight ◽  
Parenteral Nutrition ◽  
Clinical Efficacy ◽  
Premature Infants ◽  
Feeding Intolerance ◽  
Disappearance Time ◽  
Basic Standard ◽  
Basic Treatment

Objective: To discuss the clinical efficacy of phentolamine in the treatment of feeding intolerance in premature infants with low birth weight. Methods: Seventy-one low-birth-weight infants with feeding intolerance were randomly divided into the phentolamine group and the erythromycin group (38 patients and 33 patients, respectively). The infants were given basic treatment, such as gastric lavage, temporary fasting, nutritional support and abdominal massage. The phentolamine group was intravenously pumped with phentolamine as the basis of basic treatment, while the erythromycin group was given erythromycin as the basis of basic treatment. The time for gastrointestinal symptoms to disappear, the time the basic standard was reached, the time parenteral nutrition was used, the total time enteral feeding was implemented, the length of stay, and the increase in physical indexes according to the corrected gestational age of 40 weeks of the two groups were compared. Results: There was no significant difference between the phentolamine group and the erythromycin group in vomiting disappearance time or the increase in physical indicators at the corrected gestational age of 40 weeks (P>0.05), while the abdominal distension disappearance time, the time of restoration to birth weight, the time to reach the basic standard, the total time of parenteral nutrition, the total time of enteral feeding, and the length of stay in the phentolamine group were shorter than those in the erythromycin group, with significant differences (P<0.05). Conclusion: Phentolamine has a significant effect on alleviating symptoms and shortening the treatment time while treating feeding intolerance in premature infants with low birth weight, without adverse events, so it is worthy of clinical promotion. doi: https://doi.org/10.12669/pjms.36.7.2633 How to cite this:Li H, Li B, Wen X. Clinical efficacy of phentolamine in the treatment of feeding intolerance in premature infants with low birth weight. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.2633 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Clinical Efficacy of Starter Parenteral Nutrition in Very Low Birth Weight Infants

2021 ◽  
Vol 38 (4) ◽  
pp. 462-472
Author(s):  
Jee Hyun Sung ◽  
Na Ri Lim ◽  
Eun Yong Jeon ◽  
Hu Kyoung Lee ◽  
Se In Sung ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Parenteral Nutrition ◽  
Clinical Efficacy ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants

scholarly journals Does Feeding Intolerance in Very Low Birth Weight Premature Infants Predict Necrotizing Enterocolitis?

2021 ◽  
Vol 28 (1) ◽  
pp. 51-54
Author(s):  
Meliha Aksoy Okan ◽  
Elif Özalkaya ◽  
Sevilay Topcuoğlu ◽  
Nilgun Karadag ◽  
Güner Karatekin
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Premature Infants ◽  
Very Low Birth Weight ◽  
Feeding Intolerance

scholarly journals The Effect of Fish Oil-Based Lipid Emulsion and Soybean Oil-Based Lipid Emulsion on Cholestasis Associated with Long-Term Parenteral Nutrition in Premature Infants

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Leilei Wang ◽  
Jing Zhang ◽  
Jiejin Gao ◽  
Yan Qian ◽  
Ya Ling
Keyword(s):  
Birth Weight ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Soybean Oil ◽  
Premature Infants ◽  
Lipid Emulsion ◽  
Lipid Emulsions ◽  
Feeding Intolerance ◽  
Total Dosage

Purpose. To retrospectively study the effect of fish oil-based lipid emulsion and soybean oil-based lipid emulsion on cholestasis associated with long-term parenteral nutrition in premature infants.Methods. Soybean oil-based lipid emulsion and fish oil-based lipid emulsion had been applied in our neonatology department clinically between 2010 and 2014. There were 61 qualified premature infants included in this study and divided into two groups. Soybean oil group was made up of 32 premature infants, while fish oil group was made up of 29 premature infants. Analysis was made on the gender, feeding intolerance, infection history, birth weight, gestational age, duration of parenteral nutrition, total dosage of amino acid, age at which feeding began, usage of lipid emulsions, and incidence of cholestasis between the two groups.Results. There were no statistical differences in terms of gender, feeding intolerance, infection history, birth weight, gestational age, duration of parenteral nutrition, total dosage of amino acid, and age at which feeding began. Besides, total incidence of cholestasis was 21.3%, and the days of life of occurrence of cholestasis were53±5.0days. Incidence of cholestasis had no statistical difference in the two groups.Conclusion. This study did not find the different role of fish oil-based lipid emulsions and soybean oil-based lipid emulsions in cholestasis associated with long-term parenteral nutrition in premature infants.

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