A Novel Immunohistochemical Staining Method Allows Ultrarapid Detection of Lymph Node Micrometastases While Conserving Antibody

Endocrine tumors are rarely observed in pigs, and pheochromocytomas have been only punctually described. The current report describes a white and firm, 15-cm in diameter, neoplastic mass located in the adrenal gland with metastasis to regional lymph nodes in a 2.5-year-old sow. The masses had marked desmoplasia that supported a population of polygonal-to-spindle–shaped neoplastic cells arranged into cords and packets within a delicate fibrovascular stroma. Immunohistochemical staining of the tumor was positive for chromogranin and negative for neurofilament protein in adrenal and lymph node masses, which was characteristic of a malignant pheochromocytoma.

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Detection of Lymph Node Micrometastases and Isolated Tumor Cells in Sentinel and Nonsentinel Lymph Nodes of Colon Cancer Patients

World Journal of Surgery ◽

10.1007/s00268-005-0094-x ◽

2005 ◽

Vol 29 (9) ◽

pp. 1172-1175 ◽

Cited By ~ 32

Author(s):

Andreas Bembenek ◽

Ulrike Schneider ◽

Stephan Gretschel ◽

Joerg Fischer ◽

Peter M. Schlag

Keyword(s):

Colon Cancer ◽

Lymph Node ◽

Lymph Nodes ◽

Cancer Patients ◽

Tumor Cells ◽

Isolated Tumor Cells ◽

Lymph Node Micrometastases

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Detection of sentinel and non-sentinel lymph node micrometastases by complete serial sectioning and immunohistochemical analysis for gastric cancer

Journal of Experimental & Clinical Cancer Research ◽

10.1186/1756-9966-27-7 ◽

2008 ◽

Vol 27 (1) ◽

Cited By ~ 35

Author(s):

Kaname Ishii ◽

Shinichi Kinami ◽

Kenichiro Funaki ◽

Hideto Fujita ◽

Itasu Ninomiya ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Immunohistochemical Analysis ◽

Serial Sectioning ◽

Lymph Node Micrometastases

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Sentinel Lymph Node Micrometastases in Breast Cancer: Prognostic Relevance and Therapeutic Implications

From Local Invasion to Metastatic Cancer ◽

10.1007/978-1-60327-087-8_29 ◽

2009 ◽

pp. 339-345 ◽

Cited By ~ 1

Author(s):

Igor Langer ◽

Ulrich Guller ◽

Carsten Thomas Viehl ◽

Markus Zuber

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Lymph Node Micrometastases ◽

Therapeutic Implications ◽

Prognostic Relevance

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Recurrence of Lymph Node Micrometastases After Radiotherapy for Head and Neck Carcinoma: A Propensity Score-matched Study

Cancer Diagnosis & Prognosis ◽

10.21873/cdp.10022 ◽

2021 ◽

Vol 1 (3) ◽

pp. 165-172

Author(s):

YU SUZUKI ◽

KEIICHI JINGU ◽

EIICHI ISHIDA ◽

TAKAKI MURATA ◽

MASAKI KUBOZONO

Keyword(s):

Lymph Node ◽

Propensity Score ◽

Head And Neck ◽

Irradiation Dose ◽

Concurrent Chemoradiotherapy ◽

Head And Neck Carcinoma ◽

Lymph Node Micrometastases ◽

Neck Carcinoma ◽

Matched Study ◽

Observation Period

Background: The standard irradiation dose to the elective lymph node area (ELNA) in locally patients with advanced head and neck squamous cell carcinoma (LA-HNSCC) to control lymph node micrometastases (LN-MM) has not changed since it was empirically determined in the 1950s. We investigated the optimal irradiation dose for controlling LN-MM in ELNAs. Patients and Methods: The pattern of recurrence of LA-HNSCC was retrospectively evaluated in patients who underwent concurrent chemoradiotherapy with cisplatin or radiation therapy alone. Results: In total, 162 patients were enrolled. The median observation period was 34 months. No recurrence was found in ELNAs. After propensity score matching, a cisplatin dose of ≥200 mg/m2 yielded a significantly higher overall survival rate (p≤0.001) and locoregional control rate (p=0.034) than did a dose of <100 mg/m2. Conclusion: CCRT with a cisplatin dose of ≥200 mg/m2 can reduce the irradiation dose to 40-44 Gy at 2 Gy per fraction to control LN-MM.

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