Prognosis Value of Peripheral Lymphocytes Count in Colorectal Cancer Patients with Normal Serum CEA—Lymphocytes Predict Prognosis of Colorectal Cancer

2021 ◽  
Vol 11 (11) ◽  
pp. 5364-5372
Author(s):  
雅诗 蔡
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Normal Serum ◽  
Peripheral Lymphocytes ◽  
Serum Cea ◽  
Colorectal Cancer Patients

Evaluation of serum CXCL5 as a serum marker for prognosis of colorectal cancer patients.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 442-442 ◽  
Author(s):  
M. Kawamura ◽  
Y. Toiyama ◽  
K. Tanaka ◽  
H. Yasuda ◽  
H. Fujikawa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Normal Serum ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Serum Samples ◽  
Preoperative Serum ◽  
Colorectal Cancer Patients

442 Background: CXCL5 is known as CXC chemokine which promotes angiogenesis related to cancer. However, the function of serum level of CXCL5 (sCXCL5) has not been fully studied in colorectal cancer. The purpose of this study was to evaluate the relationships between preoperative sCXCL5 and clinicopathological features and prognosis in colorectal cancer. Methods: This was a single-institution, retrospective study. Preoperative serum samples of 250 colorectal cancer patients (between 1998 and 2007, median age: 65.3 years, male 159/female 91) were available for the study, and 33 normal serum was examined and used as a control. sCXCL5 level was assayed using a commercially available enzyme-linked immunosorbent assay kit, and analyzed statistically. Results: Mean level of sCXCL5 was significantly higher in colorectal cancer patients than in control group (p=0.013). Patients with liver metastases had significantly higher sCXCL5 level than those without metastases (p=0.0086), and in logistic analysis, sCXCL5 was an independent marker for predicting liver metastasis (p=0.040). Overall survival of patients with elevated sCXCL5 level was significantly worse than those with lower sCXCL5 (p=0.0006). Conclusions: Preoperative sCXCL5 level was increased in colorectal cancer patients compared to in healthy volunteer and elevated sCXCL5 was correlated with liver metastasis and poor prognosis for overall survival in colorectal cancer patients. Elevated sCXCL5 has been proposed as a useful predictive marker for liver metastasis and overall survival in colorectal cancer. No significant financial relationships to disclose.

scholarly journals Hubungan Nilai Carcinoembryonic Antigen dengan Derajat Diferensiasi pada Karsinoma Kolorektal di RSUP Prof. Dr. R. D. Kandou Manado

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
John Wesley ◽  
Toar Mambu ◽  
Heber Sapan ◽  
Winfried M. Sumanti
Keyword(s):  
Colorectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Cancer Patients ◽  
Correlation Study ◽  
North Sulawesi ◽  
Preoperative Serum ◽  
Serum Carcinoembryonic Antigen ◽  
Serum Cea ◽  
Differentiation Stage ◽  
Colorectal Cancer Patients

Abstract: Colorectal cancer is a serious health problem in Indonesia as well as in North Sulawesi. Serum carcinoembryonic antigen (CEA) is a progmostic factor in patients with this disease. This study was aimed to obtain the correlation between the histopathological differentiation stage and serum CEA level in colorectal cancer patients at Prof. Dr. R. D. Kandou Hospital Manado. This was an analytical correlation study. Subjects were colorectal cancer patients who had preoperative serum CEA level and histopathological differentiation stage results. Data were analyzed with Anova test (variant analysis) and Spearman Rho test. The results showed that there were 58 colorectal cancer patients enrolled in this study. The patients’ data were obtained from the Digestive Surgery clinic and nursery room of Prof. Dr. R. D. Kandou Hospital Manado. Of the 58 patients, 37 (63.79%) had moderate differentiated colorectal cancer. Related to serum CEA level, 23 patients (39.65%) had moderate differentiated colorectal cancer with serum CEA level 20-100 ng/ml. The Spearman Rho test showed that there was a positive correlation between serum CEA level and histopathoplogical differentiation stage of cancer (r = 0.877 and P = 0.001). Conclusion: There was a significant correlation between serum CEA level and histopathological differentiation stage of colorectal cancer. The better the differentiation stage, the higher the serum CEA level.Keywords: carcinoembryonic antigen, colorectal cancer, differentiation stageAbstrak: Karsinoma kolorektal (KKR) telah menjadi masalah kesehatan yang serius di Indonesia dan Sulawesi Utara pada khususnya. Kadar carcinoembryonic antigen (CEA) merupakan salah satu faktor prognostik pada penderita KKR. Penelitian ini bertujuan untuk mengetahui hubungan antara derajat diferensiasi histopatologik dengan kadar CEA dalam serum pada pasien KKR di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini ialah analitik korelatif. Subyek penelitian ialah 58 pasien KKR yang mempunyai hasil pemeriksaan kadar CEA serum preoperasi dan pemeriksaan derajat diferensiasi histopatologik. Analisis statistik menggunakan uji Anova (analisis variansi) dan korelasi Spearman Rho. Data pasien diambil dari pasien yang datang dan kontrol di Poliklinik Bedah Digestif serta dari ruang perawatan Bedah Digestif RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan derajat diferensiasi tumor kolorektal terbanyak ialah diferensiasi sedang/moderate differentiated yaitu 37 pasien (63,79%). Bila dihubungkan dengan nilai CEA serum, yang terbanyak ditemukan ialah jenis diferensiasi sedang pada pasien dengan kadar CEA serum 20-100 ng/ml sebanyak 23 orang (39,65%). Uji Spearman Rho memperlihatkan bahwa kadar CEA berkorelasi positif dengan derajat diferensiasi KKR (r = 0,877 dan P = 0,0001). Simpulan: Terdapat korelasi bermakna antara kadar CEA serum dan derajat diferensiasi kanker kolorektal. Derajat diferensiasi KKR yang baik memiliki kadar CEA yang tinggi.Kata kunci: carcinoembryonic antigen, karsinoma kolorektal, derajat differensiasi

scholarly journals Relationship between plasma calcium and carcinoembryonic antigen among colorectal cancer patients

2018 ◽  
Vol 5 (6) ◽  
pp. 1995 ◽  
Author(s):  
Promise N. Wichendu ◽  
Collins Amadi
Keyword(s):  
Colorectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Cancer Patients ◽  
Serum Calcium ◽  
Plasma Calcium ◽  
Study Cohort ◽  
Total Calcium ◽  
Serum Cea ◽  
Colorectal Cancer Patients ◽  
Low Serum

Background: Low serum calcium is hypothesized to influence colorectal carcinogenesis. Hence, this study was set out to investigate the pattern of plasma calcium in patients with colorectal cancer, and to determine the relationship between the mineral with carcinoembryonic antigen (CEA) among patients with colorectal cancer.Methods: This was a retrospective study of 45 colorectal cancer patients who presented to a tertiary hospital in Nigeria. The laboratory characteristics of these patients were evaluated. Records of sex, age, serum albumin, plasma total calcium, and serum CEA test results from 1st January 2008 to 31st December 2017 were retrieved from laboratory and medical records and analyzed with SPSS software version 20.Results: There were a total of 45 records of colorectal patients in this study, among them were 62.2% males and 37.8% females. The majority (57.8%) of the study cohorts are within the age group 50 to 59 years. Low total calcium was observed in 37.8% of the study cohort while 66.7% tested positive for CEA. The positive CEA group had lower total calcium level than those with negative CEA results (p = 0.001). Negative but weak correlations of total calcium and serum CEA was observed among the overall study cohort (r = -0.485; p = 0.001) and those with positive test for CEA (r = -0.384; p = 0.036).Conclusions: The evidence from this study suggests that low serum calcium could be a risk factor for colorectal cancer and is also associated with higher serum level of the CEA biomarker.

CEA tissue staining in colorectal cancer patients. A way to improve the usefulness of serial serum CEA evaluation

Cancer ◽  
1985 ◽  
Vol 55 (11) ◽  
pp. 2624-2629 ◽  
Author(s):  
Giuseppe Midiri ◽  
Claudio Amanti ◽  
Marco Benedetti ◽  
Costantino Campisi ◽  
Giuseppe Santeusanio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Serum Cea ◽  
Serial Serum ◽  
Colorectal Cancer Patients

Serum CEA monitoring in the follow-up of colorectal cancer patients with negative preoperative serum CEA

1980 ◽  
Vol 16 (8) ◽  
pp. 1099-1103 ◽  
Author(s):  
G. Mariani ◽  
M. Carmellini ◽  
F. Bonaguidi ◽  
M.A. Benelli ◽  
M.G. Toni
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Preoperative Serum ◽  
Serum Cea ◽  
Colorectal Cancer Patients

Patterns of serum CEA levels in different clinico-pathological variables of colorectal cancer

2020 ◽  
Vol 14 (2) ◽  
pp. 68-71
Author(s):  
Muhammad Hayat ◽  
Ghulam Haider ◽  
Shahid Hussain ◽  
Perwasha Kerio ◽  
Ravisha Bai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Tertiary Care ◽  
Elevated Serum ◽  
Response To Therapy ◽  
Care Hospital ◽  
Significant Difference ◽  
Serum Carcinoembryonic Antigen ◽  
Serum Cea ◽  
Colorectal Cancer Patients

Background: Globally, colorectal malignancy is the 3rd most frequent cancer and the 2nd major cause of mortality. Serum carcinoembryonic antigen (CEA) is a simple tumor marker for the diagnosis, predicting response to therapy and survival and identifying the recurrence of colorectal cancer. Therefore, the aim was to evaluate the pattern of serum CEA levels in patients with colorectal cancer presenting at a tertiary care hospital in Karachi Patients and methods: It was a cross-sectional study conducted at the Department of Medical Oncology of Jinnah Postgraduate Medical Center, Karachi from January till August 2019. One ninety-nine patients of 12-80 years age and either gender diagnosed with colorectal cancer (biopsy-proven) were included. Data on demographics, clinical and pathological findings were recorded in the pre-designed proforma. The serum CEA levels in colorectal cancer patients were assessed using an ELISA kit. CEA levels higher than 5.0 ng/mL were deemed as elevated CEA levels in colorectal patients. Data were analyzed using SPSS version 23. Results: A total of 191 colorectal cancer patients were included. The mean age of the patients was 42.81±15.22 years. Most of the patients (61.3%) were male. Out of 191 colorectal cancer patients, 60 (31.4%) had CEA level 0-0.3 ng/ml, whereas 79 (41.4%) had elevated serum CEA level (>10 ng/ml). The CEA levels were stratified with respect to effect modifiers. The size of the tumor, TNM staging and localization and metastasis of cancer showed a statistically significant difference between levels of CEA (p<0.05). Conclusion: The raised CEA levels are associated with clinically progressive or presence of residual and recurrent disease. For patients with progressive tumors, particularly colorectal carcinoma, CEA assays are an important guide to assess the burden of the tumor, hence clinicians and surgeons ought to monitor antigen levels. It is recommended to enhance the clinical efficacy of the CEA levels.

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