Mechanism of Thrombin-Induced Changes in Vascular Endothelial Cell Permeability

2021 ◽  
Vol 11 (02) ◽  
pp. 96-105
Author(s):  
浩文 叶
Keyword(s):  
Endothelial Cell ◽  
Vascular Endothelial Cell ◽  
Cell Permeability ◽  
Vascular Endothelial ◽  
Endothelial Cell Permeability ◽  
Induced Changes

scholarly journals Diesel exhaust particles modulate vascular endothelial cell permeability: Implication of ZO-1 expression

2010 ◽  
Vol 197 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Rongsong Li ◽  
Zhi Ning ◽  
Jeffrey Cui ◽  
Fei Yu ◽  
Constantinos Sioutas ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Diesel Exhaust ◽  
Vascular Endothelial Cell ◽  
Diesel Exhaust Particles ◽  
Cell Permeability ◽  
Vascular Endothelial ◽  
Endothelial Cell Permeability ◽  
Exhaust Particles

TOMOR NECROSIS FACTOR AND INTERLEUKIN 1-α INCREASE VASCULAR ENDOTHELIAL CELL PERMEABILITY

1988 ◽  
Vol 16 (4) ◽  
pp. 396
Author(s):  
James A Royall ◽  
Roger L Berkow ◽  
Joseph S Beckman ◽  
Bruce A Freeman
Keyword(s):  
Endothelial Cell ◽  
Interleukin 1 ◽  
Vascular Endothelial Cell ◽  
Cell Permeability ◽  
Vascular Endothelial ◽  
Endothelial Cell Permeability ◽  
Necrosis Factor

Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability

1989 ◽  
Vol 257 (6) ◽  
pp. L399-L410 ◽  
Author(s):  
J. A. Royall ◽  
R. L. Berkow ◽  
J. S. Beckman ◽  
M. K. Cunningham ◽  
S. Matalon ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Interleukin 1 ◽  
Endotoxic Shock ◽  
Cell Monolayer ◽  
Vascular Endothelial Cell ◽  
Cell Permeability ◽  
Vascular Endothelial ◽  
Endothelial Cell Permeability ◽  
Necrosis Factor

Endotoxic shock is associated with acute vascular endothelial injury resulting in edema. Tumor necrosis factor (TNF) and interleukin 1 (IL-1) are cytokines produced by endotoxin-stimulated mononuclear phagocytes that are potential mediators of endotoxic shock. In this study, we investigated the effects of TNF and IL-1 alpha on vascular endothelial cell permeability in vitro. The movement of radiolabeled macromolecules of different sizes (57Co-vitamin B12, 125I-cytochrome c, and 131I-albumin; 6.5-35A) across bovine aortic endothelial cell monolayers was measured after exposure to these cytokines. TNF induced a time- and dose-dependent increase in endothelial cell monolayer permeability that was enhanced in the presence of serum. The peak increase was noted after 12 h of incubation with less alteration of permeability with longer incubations. IL-1 alpha caused a similar time-dependent increase in endothelial cell monolayer permeability, but the peak effect of IL-1 alpha was seen after 24 h. Therefore the increased permeability seen with TNF cannot be explained by release of endogenous IL-1 alone. Neither TNF nor IL-1 alpha increased release of [14C]adenine, and the only effect on lactate dehydrogenase release was a small, but statistically significant, increase after 24 h of incubation. From these studies, we conclude that TNF and IL-1 alpha directly increase vascular endothelial cell permeability in vitro and speculate that these cytokines may be involved in the acute vascular endothelial injury associated with endotoxic shock.

scholarly journals P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability

2004 ◽  
Vol 95 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Naoko Tanaka ◽  
Kumiko Kawasaki ◽  
Namie Nejime ◽  
Yoko Kubota ◽  
Kazuki Nakamura ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Vascular Endothelial Cell ◽  
Cell Permeability ◽  
Vascular Endothelial ◽  
P2y Receptor ◽  
Human Vascular Endothelial Cell ◽  
Endothelial Cell Permeability
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