scholarly journals A systematic review and critical evaluation of inflammatory cytokine associations in hidradenitis suppurativa

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1930 ◽  
Author(s):  
John W. Frew ◽  
Jason E. Hawkes ◽  
James G. Krueger
Keyword(s):  
Systematic Review ◽  
Hidradenitis Suppurativa ◽  
Meta Analysis ◽  
Critical Evaluation ◽  
Treatment Strategies ◽  
Large Degree ◽  
Inflammatory Conditions ◽  
Longitudinal Measurements ◽  
Chi Squared ◽  
The Impact

Background: The pathogenesis of hidradenitis suppurativa (HS) remains unclear. In order to develop effective treatment strategies, a deeper understanding of pathophysiology is needed. This is impaired by multiple small studies with inconsistent methodologies and the impact of co-occurring pro-inflammatory conditions such as smoking and obesity. Methods: This systematic review aimed to collate all published reports of cytokine studies in tissue, blood, serum and exudate. It was registered with PROSPERO (Registration number CRD42018104664) performed in line with the PRISMA checklist. Results: 19 studies were identified comprising 564 individual HS patients and 198 control patients examining 81 discrete cytokines. Methodology was highly varied and the quality of studies was generally low. There was a large degree of variance between the measured levels of cytokines. 78.2% of cytokines demonstrated heterogeneity by the chi-squared test for homogeneity and hence meta-analysis was not deemed appropriate. However, a strong and significant IL-17 signalling component was identified. Conclusions: Cytokines consistently elevated in lesional, peri-lesional and unaffected tissue are identified and discussed. Areas for further investigation include the role of dendritic cells in HS; the contribution of obesity, smoking, diabetes and the microbiome to cytokine profiles in HS; and examining the natural history of this disease through longitudinal measurements of cytokines over time.

scholarly journals Prevalence of comorbidity in Chinese patients with COVID-19: systematic review and meta-analysis of risk factors

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tingxuan Yin ◽  
Yuanjun Li ◽  
Ying Ying ◽  
Zhijun Luo
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Cerebrovascular Disease ◽  
Meta Analysis ◽  
Treatment Strategies ◽  
Chinese Patients ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Underlying Diseases ◽  
The Impact

Abstract Background Coronavirus disease 2019 (COVID-19) is an infectious disease characterized by cough, fever, and fatigue and 20% of cases will develop into severe conditions resulting from acute lung injury with the manifestation of the acute respiratory distress syndrome (ARDS) that accounts for more than 50% of mortality. Currently, it has been reported that some comorbidities are linked with an increased rate of severity and mortality among COVID-19 patients. To assess the role of comorbidity in COVID-19 progression, we performed a systematic review with a meta-analysis on the relationship of COVID-19 severity with 8 different underlying diseases. Methods PubMed, Web of Science, and CNKI were searched for articles investigating the prevalence of comorbidities in severe and non-severe COVID-19 patients. A total of 41 studies comprising 12,526 patients were included. Results Prevalence of some commodities was lower than that in general population such as hypertension (19% vs 23.2%), diabetes (9% vs 10.9%), chronic kidney disease (CKD) (2% vs 9.5%), chronic liver diseases (CLD) (3% vs 24.8%) and chronic obstructive pulmonary disease (COPD) (3% vs 8.6%), while some others including cancer (1% vs 0.6%), cardiovascular disease (6% vs 1.8%) and cerebrovascular disease (2% vs 0.9%) exhibited greater percentage in COVID-19. Cerebrovascular disease (OR = 3.70, 95%CI 2.51–5.45) was found to be the strongest risk factor in disease exacerbation, followed by CKD (OR = 3.60, 95%CI 2.18–5.94), COPD (OR = 3.14, 95% CI 2.35–4.19), cardiovascular disease (OR = 2.76, 95% CI 2.18–3.49), malignancy (OR = 2.63, 95% CI 1.75–3.95), diabetes (OR = 2.49, 95% CI 2.10–2.96) and hypertension (OR = 2.13, 95% CI 1.81–2.51). We found no correlation between CLD and increased disease severity (OR = 1.32, 95% CI 0.96–1.82). Conclusion The impact of all eight underlying diseases on COVID-19 deterioration seemed to be higher in patients outside Hubei. Based on different comorbidities, COVID-19 patients tend to be at risk of developing poor outcomes to a varying degree. Thus, tailored infection prevention and monitoring and treatment strategies targeting these high-risk subgroups might improve prognosis during the COVID-19 pandemic.

scholarly journals The Burden of Hidradenitis Suppurativa Signs and Symptoms in Quality of Life: Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (13) ◽  
pp. 6709
Author(s):  
Trinidad Montero-Vilchez ◽  
Pablo Diaz-Calvillo ◽  
Juan-Angel Rodriguez-Pozo ◽  
Carlos Cuenca-Barrales ◽  
Antonio Martinez-Lopez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Hidradenitis Suppurativa ◽  
Meta Analysis ◽  
Scientific Evidence ◽  
Signs And Symptoms ◽  
Sexual Distress ◽  
The Mean ◽  
The Impact

Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating inflammatory skin disease of the hair follicle that usually presents as painful, deep-seated inflamed lesions in the apocrine gland-bearing areas of the body. HS patients suffer from uncomfortable signs and symptoms, such as pain, pruritus, malodour and suppuration, which may impair patients’ quality of life (QoL). Although HS patients frequently experience these signs and symptoms, they are only occasionally assessed by clinicians and, unexpectedly, the scientific evidence available is limited and heterogeneous. The aim of this study is to summarize the evidence regarding the impact of HS signs and symptoms on QoL to serve as a basis for future research and help clinicians to consider them in the daily care of HS patients. A systematic review and meta-analysis were conducted following PRISMA Guidelines. The following search algorithm was used: (hidradenitis or “acne inversa”) and (pain or itch or odour or malodour or suppuration or oozing or drainage) and (“quality of life”). The literature search identified 836 references, 17 of them met the eligible criteria and were included for analysis, representing 4929 HS patients. Mean age of the participants was 36.28 years and there was a predominance of female sex among study participants. The BMI of the population was in the range of over-weight and about two out five patients were active smokers. Studies included patients with mild to moderate HS, with a mean disease duration of 13.69 years. The HS signs and symptoms assessed were pain, pruritus, malodour and suppuration. Overall, the higher intensity of a sign or symptom correlated with poorer general QoL or specific QoL dimensions including sexual distress, anxiety, depression and sleep. The most frequently employed tool to assess QoL was the Dermatology Life Quality Index (DLQI). DLQI was used in 52.9% of the studies (9/17) with a mean value of 10.70 (2.16 SD). The scores employed to assess signs and symptoms severity were subjective and varied between studies, being the numerical rating scale (NRS) for each of the most used symptoms. The mean NRS value for pain was 3.99 and the mean NRS for pruritus was 4.99. In conclusion, we have summarized, categorized and analyzed the scientific evidence regarding signs and symptoms in HS patients and their impairment in QoL. Their assessment should be thorough and included during routine evaluation of HS patients to motivate therapeutic modifications and increase patients’ health.

scholarly journals Role of Anxiety and Depression in Altering Immune System Associated with Breast Cancer. Systematic Review

2021 ◽  
Vol 6 (1) ◽  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Treatment Strategies ◽  
Anxiety And Depression ◽  
Immune Systems ◽  
Mesh Terms ◽  
Psychological Pressure ◽  
As Stress ◽  
The Impact

Background: Focusing on basic and clinical research, psycho-neuroimmunology researchers are looking at how the factors that cause anxiety and depression and their negative emotions can affect physiological and health conditions. Clinical studies have shown that the central nervous system is associated with endocrine and immune systems. Objectives: To investigate the impact of depression and anxiety on developing breast cancer through immune disturbance pathway Methodology: The present study is a descriptive review of systematic review studies conducted in accordance with the guidelines for preferred cases for reporting systematic and meta-analysis review articles (prisma). Electronic databases including ISI Web of Knowledge, PubMed, and Scopus, were searched from 2012 to 2020. The search strategy psychological, immune response, anxiety disorder, depression, and psychoneuroimmunology. Additionally, we searched the references of retrieved articles to find additional included a combination of the following Medical Subjects Headings (MeSH) terms: breast cancer, potentially related studies. We have considered herbal therapies, which were applied orally, or topically. The content of all articles was evaluated qualitatively after extracting from the desired databases with PRISMA checklist. Results: the impact of psychological problems on people’s illness is very large, when people have a lot of psychological pressure, the incidence will be higher than ordinary people. Health Psychology considers human health to be a complex entity and believes that disease is not caused by a single factor but is the product of biological, psychological, and social factors. Recent research has previously confirmed the effect of psychosocial factors such as stress and how it reacts to the onset and course of the disease. Most of the patients with malignant tumor had negative emotional problems such as anxiety and depression. Depression in cancer is markedly different from depression in healthy individuals, and involves a unique symptomatology and a strong biological etiology. Conclusions: A better understanding of the bidirectional communication between the neuroendocrine and immune systems could contribute to new clinical and treatment strategies.

scholarly journals The impact of lymphadenectomy on survival outcomes of ovarian clear cell carcinoma: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yan Liu ◽  
Changzhen Huang ◽  
Ran Chu ◽  
Xingsheng Yang ◽  
Beihua Kong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Meta Analysis ◽  
Treatment Strategies ◽  
Disease Free Survival ◽  
Ovarian Clear Cell Carcinoma ◽  
Free Survival ◽  
The Impact

Background: The treatment strategies for ovarian clear cell carcinoma (OCCC) are the same as those for epithelial ovarian cancer. Due to the rarity of OCCC, no prospective studies of its surgery have been reported. Therefore, the therapeutic significance of lymphadenectomy for OCCC needs to be further clarified. Objectives: To assess the effectiveness of lymphadenectomy in patients with ovarian clear cell carcinoma by a meta-analysis. Search Strategy: The Web of Science, Scopus, PubMed, and other sources (e.g. Google Scholar) were searched from each database’s earliest inception to June 2021. Selection Criteria: English-language publications of observational studies that investigated the role of lymphadenectomy in patients with OCCC were included. Data Collection and Analysis: The pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated. Main Results: The analysis demonstrated that lymphadenectomy is associated with significantly improved disease-specific survival (DSS) (HR=0.76; 95%CI=0.60-0.95; P=0.02; I2= 0.0%) and disease-free survival (DFS) (HR=0.58; 95%CI=0.33-1.00; P=0.05; I2=61%), but not for overall survival (OS) (HR=0.80; 95%CI=0.60-1.06; P=0.12; I2= 19%) and progression-free survival (PFS) (HR=0.95; 95%CI=0.64-1.42; P=0.79; I2= 0.0%). But it is worth noting that several single studies indicated a tendency of improved OS, PFS, DFS, DSS with lymphadenectomy. Conclusions: Lymphadenectomy could not significantly improve OS and PFS for OCCC, but is associated with improved DFS and DSS. Gynecologic oncologists should tailor treatment to patients to achieve optimal outcomes. And further studies are necessary to validate the impact of lymphadenectomy on OCCC. Keywords: ovarian clear cell carcinoma, lymphadenectomy, survival, systematic review, meta- analysis

scholarly journals The Impact of Inclusion Setting on the Academic Performance, Social Interaction and Self-Esteem of Deaf and Hard of Hearing Students: Systematic Review and Meta-Analysis

2020 ◽  
Vol 19 (10) ◽  
pp. 248-264
Author(s):  
Sulaiman M. Alshutwi ◽  
Aznan Che Ahmad ◽  
Lay Wah Lee
Keyword(s):  
Systematic Review ◽  
Academic Performance ◽  
Social Interaction ◽  
Hard Of Hearing ◽  
Meta Analysis ◽  
Critical Evaluation ◽  
Self Esteem ◽  
Cochrane Library ◽  
Future Research ◽  
The Impact

This research investigates the impact of inclusion setting on academic performance, social interaction, and deaf and hard-of-hearing (D/HH) students’ self-esteem. As opposed to the traditional nature of conducting a literature review, meta-analysis has the advantage of offering a critical evaluation of several previous studies with a common theme and combining their results. This has the potential of increasing statistical power which improves the generalizability of findings to a wider population. Thus, this study provides important conclusions that are likely to influence future research and decisions made by policymakers regarding the impact of inclusion setting on academic performance, social interaction and self-esteem of D/HH students. Guidelines of PRISMA (2009) was adopted for searching relevant studies by using keywords. The websites of World Library World Cat, Cochrane Library, Web of Science, Biomed Central, Psyc INFO, Global Health, MEDLINE, EMBASE, PubMed, and Google Scholar were searched for relevant research conducted from January 1st, 1990 to February 28th, 2020. Therefore, the present study is a systematic review of the studies followed by a meta-analysis of proportions carried out using Med Calc online software. The results of the present findings have demonstrated that inclusion setting improves academic performance, social interaction, and self-esteem of D/HH students. Based on our findings, we recommend that D/HH children should have access to a ‘good inclusion setting’. Therefore, policymakers and practitioners ought to advocate the need for developing special strategies for such children.

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