scholarly journals Case Report: rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1218
Author(s):  
Hadeer Rizk Saad ◽  
Noura M. Kamal ◽  
Hatem W. Amer
Keyword(s):  
Connective Tissue ◽  
Giant Cell ◽  
Bone Lesion ◽  
Giant Cells ◽  
World Health ◽  
Ossifying Fibroma ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Juvenile Ossifying Fibroma

Central giant cell granuloma (CGCG) is classified by the World Health Organization as a benign bone lesion. It is found anteriorly in the mandible, with most of the cases crossing the midline. In total, 70% of CGCGs are encountered in young females. Fibro-osseous lesions are a group of pathologies that encompass neoplastic, dysplastic and reactive entities. Juvenile ossifying fibroma, which can be further categorized into juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma, represents an aggressive neoplastic example of these fibro-osseous lesions. JTOF occurs in children at almost equal ratios in both sexes, affecting the maxilla more than mandible. This study aims to report a peculiar case of a hybrid lesion comprising CGCG and JTOF in the mandible of a nine-year-old female patient. Clinical, radiographic and histopathological findings were assessed. Clinical examination revealed an intraoral swelling extending from the right impacted third molar area to the left first molar area. Computed tomography showed a well-defined multilocular radiolucency with diffuse flecks of radioopacities. Histopathologically, the lesion comprised fibrous connective tissue encompassing numerous multinucleated giant cells and other areas of cell-rich connective tissue stroma containing bands of osteoid matrix and anastomosing immature bone trabeculae intermixed with scattered clusters of multinucleated giant cells. We hereby report a case of a rare hybrid lesion comprising CGCG and JTOF.

scholarly journals A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

2021 ◽  
Vol 6 (2) ◽  
pp. 155-158
Author(s):  
Rohini Sebastian ◽  
Meethu Rappai
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Parathyroid Adenoma ◽  
Giant Cell ◽  
Stromal Cells ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

scholarly journals Central Giant Cell Granuloma

2019 ◽  
Vol 2 (1) ◽  
pp. 01-04
Author(s):  
Nilotpol Kashyap ◽  
Manisha Upadhyay ◽  
Rupam Tripathi ◽  
Pallavi Pawar ◽  
Ranjeet Kumar Prasad Sah ◽  
...  
Keyword(s):  
Giant Cell ◽  
Fibrous Tissue ◽  
Giant Cells ◽  
World Health ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion ◽  
Benign Tumours ◽  
Health Organization ◽  
Intraosseous Lesion

Central giant cell granuloma (central giant cell granuloma) is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the jaws [1]. The World Health Organization (WHO) has defined central giant cell granuloma as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells and occasional trabeculae of woven bone [2]. Central giant cell granuloma occurs predominantly in children or young adults, with approximately 75%of cases presenting before 30 years of age although presentation can occur at any age [3]. Females are affected more frequently than males, with a ratio of 2:1

scholarly journals Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

2022 ◽  
Author(s):  
Monir Moradzadeh Khiavi ◽  
Abbas Karimi ◽  
Hassan Mirmohammad Sadeghi ◽  
Samira Derakhshan ◽  
Seyed Mobin Tafreshi ◽  
...  
Keyword(s):  
Giant Cell ◽  
Benign Lesion ◽  
Excisional Biopsy ◽  
Giant Cells ◽  
Histopathological Analysis ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Odontogenic Fibroma ◽  
Central Odontogenic Fibroma

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.  

Cellular cannibalism in giant cells of central giant cell granuloma of jaw bones and giant cell tumors of long bones

2016 ◽  
Vol 8 (2) ◽  
pp. e12214 ◽  
Author(s):  
Gargi S. Sarode ◽  
Sachin C. Sarode ◽  
Shailesh Gawande ◽  
Snehal Patil ◽  
Rahul Anand ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Long Bones ◽  
Giant Cell Granuloma ◽  
Giant Cell Tumors ◽  
Central Giant Cell Granuloma ◽  
Jaw Bones

Synchronous Central Giant Cell Granuloma and Ossifying Fibroma of the Mandible

2012 ◽  
Vol 23 (6) ◽  
pp. e645-e647
Author(s):  
Bong Chul Kim ◽  
Jun Lee ◽  
Boyoung Choi ◽  
Seung-Ki Min ◽  
Jung-Hoon Yoon
Keyword(s):  
Giant Cell ◽  
Ossifying Fibroma ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma

scholarly journals A UNIQUE CASE REPORT OF AGGRESSIVE CENTRAL GIANT CELL GRANULOMA OF THE MANDIBLE TREATED WITH CONSERVATIVE SURGICAL ENUCLEATION WITH LONG TERM FOLLOW-UP

2019 ◽  
Author(s):  
Gourab Das ◽  
Bharat Shukla ◽  
Dhritiman Pathak ◽  
Abhishek Singh ◽  
Shailesh Kumar
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Woven Bone ◽  
Long Term Follow Up ◽  
Benign Tumours ◽  
Bone Trabeculae ◽  
Surgical Aspects

Central Giant Cell Granuloma (CGCG) is an intrabony lesion showing cellular fibrosis with numerous foci of haemorrhage, woven bone trabeculae and multinucleated giant cells. It is more commonly found in the mandible than maxilla. Among all benign tumours of jaw, it accounts for less than 7%. According to the reports, in approximately 48% cases, it is diagnosed in the first two decades of life and in almost 60% cases, before 30 years of age. This paper presents a case of CGCG involving the mandibular left anterior region of a female patient with clinical, radiological, histopathological and surgical aspects of the lesion. Key Words- Central Giant Cell Granuloma (CGCG), CONSERVATIVE SURGICAL ENUCLEATION

scholarly journals Annular Elastolytic Giant Cell Granuloma - A Rare Case with Systemic Involvement

2016 ◽  
Vol 15 (3) ◽  
pp. 488-491
Author(s):  
Suchibrata Das ◽  
Joyeeta Chowdhury ◽  
Sangita Patra ◽  
Arun Achar
Keyword(s):  
Giant Cell ◽  
Cell Lymphoma ◽  
Medical Science ◽  
Giant Cells ◽  
Elastic Fibers ◽  
Cutaneous T Cell Lymphoma ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Systemic Involvement ◽  
Exposed Skin

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous dermatosis characterized by loss of elastic fibers and elastophagocytosis by multinucleated giant cells. It is characterized by annular plaques that are similar to those observed in granuloma annulare but that specifically appear in sun-exposed skin and occurs more commonly in females than males. There have been reported cases of AEGCG associated with diabetes mellitus, systemic sarcoidosis, cutaneous amyloidosis, molluscum contagiosum, squamous cell carcinoma of the lung and cutaneous T-cell lymphoma. We report a case of AEGCG in both sun-exposed as well as covered areas of a middle aged lady with hepatic nodules and Barret’s esophagus.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.488-491

scholarly journals Giant cell tumor of bone in an eighteenth-century Italian mummy

2021 ◽  
Author(s):  
Luca Ventura ◽  
Enrico Petrella ◽  
Sara Piciucchi ◽  
Elisabetta Cilli ◽  
Donata Luiselli ◽  
...  
Keyword(s):  
Eighteenth Century ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Bone Cyst ◽  
Giant Cells ◽  
Cell Tumor ◽  
World Health ◽  
Ossifying Fibroma ◽  
Small Subset ◽  
Left Femur

AbstractGiant cell tumor (GCT) of the bone is a locally aggressive and rarely metastasizing neoplasm. It is composed of neoplastic mononuclear stromal cells with a monotonous appearance admixed with macrophages and osteoclast-like giant cells. In a small subset of cases, GCT is malignant. Terminology previously related to this entity, and which is no longer supported by the World Health Organization, includes osteoclastoma and benign fibrous histiocytoma (BFH). Giant cells occur in numerous other pathologic conditions of the bone, which accounts for the misrepresentation of these non-GCT tumors in the early literature. Non-ossifying fibroma (NOF), aneurysmal bone cyst, and chondroblastoma have been erroneously labeled GCT for this reason. A single description of an ancient GCT was reported by Brothwell and Sandison and subsequently mentioned by Aufderheide and Rodrìguez-Martìn who were astonished that more of these tumors had not been identified in archaeological cases. To the best of our knowledge, no other cases of ancient GCT have been cited in the paleopathology literature. The study of this type of neoplasm in antiquity can be used as a means to better understand its characteristics and behavior and to expand the depth of time of the etiology of these lesions. We report a case of GCT of the left femur observed following the total body CT imaging of a partially mummified adult female, dating to eighteenth century.

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