The Relationship between Total Ige and Neutrophils Count with Degrees of Asthma Control in Adult Atopic Patients

The present issue of Multidisciplinary Respiratory Medicine includes a paper by Bora et al. [1] investigating the relationship between the asthma control test (ACT) and airway inflammation. In a group of stable asthmatic patients admitted to a pulmonary outpatient clinic, the authors carried out the ACT, pulmonary function tests, methacholine bronchial provocation test (MBPT), fractional exhaled nitric oxide level (FeNO), and induced sputum test. [...]

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Neuropeptide Y as a potential biomarker in patients with asthma and obesity

Russian Pulmonology ◽

10.18093/0869-0189-2021-31-6-759-767 ◽

2021 ◽

Vol 31 (6) ◽

pp. 759-767

Author(s):

Yanina S. Shkatova ◽

Sergey N. Avdeev ◽

Andrey V. Budnevsky ◽

Ludmila V. Tribuntceva

Keyword(s):

Body Weight ◽

Oxidative Damage ◽

Neuropeptide Y ◽

Asthma Control ◽

Clinical Course ◽

Inverse Correlation ◽

Positive Correlation ◽

Normal Body ◽

Normal Body Weight ◽

The Relationship

The phenotype of asthma with obesity is particularly difficult to treat, while its prevalence is increasing. In recent years, special attention has been paid to neuropeptide Y (NPY) due to its possible effect on the severity of the clinical course of asthma.Aim. To identify the relationship between the level of NPY and the clinical course of asthma in patients with obesity and overweight.Methods. The study included 113 patients (27, or 23.89% of men and 86, or 76.11% of women) diagnosed with asthma of moderate severity, whose average age was 57.81 ± 13.05 years. Patients were divided into three groups — with normal body weight, overweight, and obesity. The examination included spirometry, body mass index (BMI), and a questionnaire. Also, Asthma Control Test (ACT) was used. The levels of leptin, adiponectin, NPY, and general oxidative damage were measured in all patients.Results. Asthma control was significantly lower in the group of patients with asthma and obesity compared with the normal body weight and overweight patients. Leptin level was significantly higher in the group of patients with asthma and obesity compared with the normal body weight and overweight patients. The level of NPY was significantly higher in the group of patients with obesity than in the patients with normal body weight and overweight. No significant differences in the level of adiponectin were found between the groups. The NPY level had a high inverse correlation with VLC index, a moderate/medium inverse correlation with forced expiratory volume in 1 sec, forced expiratory flow (FEF) at 25%; forced vital capacity, Tiffno index, FEF 50%, peak expiratory flow, ACT score, and a moderate positive correlation with the level of total oxidative damage.Conclusion. A higher level of NPY is observed in patients with asthma and obesity. This level has an inverse correlation with spirometric parameters, asthma control (evaluated via ACT) and a positive correlation with the level of general oxidative damage, which indicates a possible proinflammatory effect of NPY that contributes to an unfavorable course of asthma. Thus, further studies are required to establish the nature of the relationship between NPY and asthma exacerbations, as well as the mechanism of NPY influence on asthma pathogenesis.

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Is There Benefit in Identifying Asthma Triggers During an Exacerbation?

Clinical Pediatrics ◽

10.1177/0009922819887399 ◽

2019 ◽

Vol 59 (2) ◽

pp. 142-147

Author(s):

Pushpom James ◽

Anna Cornish ◽

Kaylan Brady ◽

Jennifer Morrison ◽

Yvonne Giunta ◽

...

Keyword(s):

Prospective Study ◽

Asthma Control ◽

Asthma Exacerbation ◽

Pediatric Patients ◽

Objective Assessment ◽

Specific Ige ◽

Total Ige ◽

Symptom Resolution ◽

A Prospective Study ◽

Asthma Triggers

Introduction. Allergen-specific IgE (sIgE) testing provides an objective assessment of sensitization to an allergen. Goal. To identify the time when serum measurements of sIgE would be most sensitive. Methods. This was a prospective study conducted between September 1, 2015, and February 25, 2019. Subjects ≥5 and ≤18 years of age, seen in the ED or admitted with an asthma exacerbation, were tested for total IgE and 8 perennial sIgE levels. Subjects with elevated sIgE were tested again after symptom resolution. Results. A total of 104 subjects were enrolled; 50 subjects were eligible for inclusion in the analysis. There were statistically significant differences between the visits for all sIgE, except Alternaria alternatum. Conclusions. In pediatric patients, serum sIgE levels measured during an asthma exacerbation were elevated compared with when their asthma was in better control. sIgE testing during an asthma exacerbation may help identify asthma triggers, mitigate exposure, and hence improve asthma control.

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