scholarly journals Serum Bilirubin Levels Can Predict Pancreatic and Biliary Malignancies in Patients with Obstructive Jaundice and Non-conclusive Cytology

2018 ◽  
Vol 6 (1) ◽  
pp. 11-15
Author(s):  
Assad Khan ◽  
Snehal Lapsia ◽  
Mohammed Aslam ◽  
Vishal Kaushik ◽  
Yogi Reddy ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Serum Bilirubin ◽  
Biliary Malignancies

scholarly journals Pre-drainage estimation of the serum bilirubin decreasing rate "b" in patients with obstructive jaundice due to malignancy, in special relation to usefullness of .DELTA.c-AMP15.

Kanzo ◽  
1989 ◽  
Vol 30 (12) ◽  
pp. 1738-1739
Author(s):  
Takao KOJIMA ◽  
Takashi KANO ◽  
Koshiro SAITO ◽  
Hideko KAWAI ◽  
Yosuke KOSHINO ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Serum Bilirubin ◽  
Special Relation

Cholestasis of the Newborn (Obstructive Jaundice)

1983 ◽  
Vol 5 (6) ◽  
pp. 163-171
Author(s):  
Lawrence M. Gartner
Keyword(s):  
Obstructive Jaundice ◽  
Serum Bilirubin ◽  
General Rule ◽  
Water Soluble ◽  
Total Serum Bilirubin ◽  
Total Serum ◽  
Diagnostic Significance ◽  
Unconjugated Hyperbilirubinemia ◽  
Mechanical Interference ◽  
Clinically Significant

Obstructive jaundice of the newborn is a misnomer as fewer than half of all cases usually referred to as "obstructive jaundice" result from mechanical interference with the flow of bile. In the majority of cases, intrinsic liver disease is the cause of this type of jaundice. The term "cholestasis" more comprehensively describes the various disorders and the pathophysiology, which includes retention of direct-reacting (conjugated) bilirubin, bile acids, and other components of bile. Direct-reacting hyperbilirubinemia is almost always the first definitive sign of hepatobiliary dysfunction, often appearing during the first weeks of life just as the normally occurring, indirect-reacting (unconjugated) hyperbilirubinemia of physiologic jaundice of the newborn is receding. Initially, there may be uncertainty as to the significance of the persisting or recurring jaundice, particularly whether the direct-reacting fraction is elevated. As a general rule, when the direct-reacting portion exceeds 2.0 mg/dl and is more than 10% of the total serum bilirubin, it should be considered clinically significant. Although the direct-reacting fraction may occasionally account for 90% of total serum bilirubin, in most cases the direct-reacting portion will range only from 25% to 75%. The degree of variation has no diagnostic significance. As only water-soluble, direct-reacting bilirubin is excreted by the kidney, the presence of bilirubinuria may be used as confirmation of elevation of the direct-reacting fraction.

Jaundice

2013 ◽  
pp. 207-232
Author(s):  
Daniel Marks ◽  
Marcus Harbord
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Obstructive Jaundice ◽  
Autoimmune Hepatitis ◽  
Viral Hepatitis ◽  
Alcoholic Hepatitis ◽  
Serum Bilirubin ◽  
Biliary Cirrhosis ◽  
Drug Induced ◽  
Elevated Bilirubin ◽  
Yellow Pigmentation

Assessment and causes of jaundice Viral hepatitis Alcoholic hepatitis Drug-induced hepatitis Autoimmune hepatitis Haemochromatosis Wilson’s disease Primary biliary cirrhosis Ischaemic hepatitis Obstructive jaundice Acholuric jaundice Sepsis Jaundice refers to yellow pigmentation of the skin and sclera caused by elevated bilirubin levels. It is usually clinically detectable when serum bilirubin concentrations rise above 60...

scholarly journals Liver function trends after biliary decompression in obstructive jaundice: a clinico-pathological-biochemical study

2019 ◽  
Vol 7 (1) ◽  
pp. 168
Author(s):  
Mohan Lal ◽  
Prabhu Dayal
Keyword(s):  
Obstructive Jaundice ◽  
Serum Bilirubin ◽  
Surgical Intervention ◽  
Biochemical Study ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Recovery Profile ◽  
Common Causes ◽  
Liver Functions ◽  
Malignant Lesions ◽  
Biochemical Assessment

Background: Liver functions tests suggest the underlying cause, estimate the severity, assess prognosis and monitor efficacy of therapy. Severity of liver dysfunction when performed serially may predict prognosis and may be helpful in assessing response to medical therapy or a surgical intervention.Methods: The data was collected in thirty cases of surgical obstructive jaundice in terms of age, sex, etiology, clinical presentation, surgical intervention for biliary drainage and the laboratory liver biochemical and coagulation profiles on a day prior to surgical intervention and post-operatively on 1st week and 4th week were recorded.Results: Of total 30 patients 56.66% were females. Patients with 73.68% of benign disease and 100% of malignant disease were of age more than 40 years. 63.33% of patients had benign cause for biliary obstruction. Choledochoithiasis and periampullary carcinoma were two most common causes of obstructive jaundice. The commonest complaints were; yellowish discolouration of sclera and skin, high colored urine (100%) and acholic stool (70%). Hepatomegaly, palpable gallbladder and ascites were observed in only malignant conditions. Serum bilirubin and transaminases were significantly higher in patients with malignant lesions on pre-operative and postoperative assessment. After decompression the rate of fall of serum bilirubin, serum glutamic-oxaloacetic transaminase and SGPT were almost identical in both benign and malignant biliary obstructions. However, a better biochemical recovery profile was observed in patients with benign lesions, as they returned to normal by 4 weeks but remained at 2 to 3 times of the normal in malignant lesions.Conclusions: Sequential biochemical assessment of liver functions has diagnostic as well as prognostic value in surgical obstructive jaundice.

scholarly journals Obstructive jaundice induces early depression of mitochondrial respiration in rat hepatocytes

2007 ◽  
Vol 22 (4) ◽  
pp. 251-254 ◽  
Author(s):  
Riad Naim Younes ◽  
Renato Sergio Poggetti ◽  
Belchor Fontes ◽  
Mario Matsuo Itinoshe ◽  
Vanda Mitie Yoshida ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Mitochondrial Respiration ◽  
Serum Bilirubin ◽  
Liver Mitochondria ◽  
High Energy ◽  
Serum Bilirubin Level ◽  
Total Serum Bilirubin ◽  
Total Serum ◽  
Control Procedure ◽  
O2 Consumption

INTRODUCTION: Oxidative phosphorylation dysfunction of hepatocyte mitochondria is involved in the pathophysiology of organ dysfunction following obstructive jaundice (OJ). However the time period from biliary occlusion to the occurrence of the dysfunction has not been determined decisively. PURPOSE: To evaluate the early effects (1 d and 7 d) of OJ on liver mitochondria respiratory function in rats. METHODS: Male Wistar rats (200-250 g) were randomly divided into the following 3 groups: laparotomy plus OJ for 24 h (1d group) (n = 10); laparotomy plus OJ for 7 d (7d group) (n = 10); sham control procedure (CTR group) (n = 12). At the end of OJ periods, total serum bilirubin level, hepatic enzyme activity levels (GOT, GTP, Gama-GT, ALP), mitochondrial respiration phases S3 and S4, as well as the respiratory control ratio (RC = S3/S4), and ADP consumption/oxygen consumption (ADP/O) ratio, were determined. RESULTS: Total serum bilirubin, activity of most hepatic enzymes, and O2 consumption during basal (S4) respiration were increased in the 1d and 7d groups (ANOVA, p = 0.05 vs. CTR). After ADP addition, the O2 consumption rate (S3) in the 1d group remained similar to the CTR rate (ANOVA p > .05), while the RC rate was reduced (ANOVA, p = 0.001) vs. CTR. The effects observed on mitochondrial respiration in the 1d group were exacerbated in the 7d group. CONCLUSION: These results indicate that OJ induces early (24 h) depression of liver mitochondria respiration, and thus may lead to early reduction in the production of high energy bonds.

scholarly journals Retrospective analysis of the efficacy of percutaneous transhepatic biliary drainage in palliation of obstructive jaundice in patients with carcinoma gall bladder: Experience from tertiary care center in Northern India

2021 ◽  
Vol 12 (11) ◽  
pp. 98-103
Author(s):  
Milind B. Sawant ◽  
S. Harish ◽  
Nishant Lohia ◽  
S. Anand ◽  
Manoj Prashar ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Obstructive Jaundice ◽  
Gall Bladder ◽  
Biliary Drainage ◽  
Serum Bilirubin ◽  
Percutaneous Transhepatic Biliary Drainage ◽  
Care Center ◽  
Tertiary Care ◽  
Gall Bladder Cancer ◽  
Transhepatic Biliary Drainage

Background: Percutaneous Transhepatic Biliary Drainage (PTBD) is a minimally invasive procedure to palliate the biliary obstruction caused by unresectable malignancy. Aims and Objective: To analyze the outcome of PTBD in patients of unresectable gall bladder cancer presenting with obstructive jaundice in terms of reduction in serum bilirubin levels, symptomatic improvement, and overall survival (OS) at 4 weeks and 12 weeks following the procedure. Materials and Methods: In this retrospective study, PTBD was attempted on 30 patients diagnosed with inoperable gall bladder cancer. Various patient and procedure-related variables were analyzed and recorded both pre and post-PTBD. Outcome data on OS was collected at 4 weeks and 12 weeks. Results: Technical success was achieved in 29 (99.66%) patients. The mean fall in the serum bilirubin at the 7th post-procedural day was 41.5% after the successful PTBD. The most common complication in our study was cholangitis noted in six (21%) patients. OS at 4 weeks and 12 weeks was 79% and 41%, respectively. Conclusion: Younger age and good performance status favored better survival rate in our study.

scholarly journals Clinical Profile and Management Techniques of Surgical Obstructive Jaundice Cases in a Tertiary Center at Bareilly

2019 ◽  
Vol 05 (01) ◽  
pp. 026-030
Author(s):  
Shailendra Kumar Singh ◽  
Porus Choudhary ◽  
Ruby Yadav
Keyword(s):  
Obstructive Jaundice ◽  
Serum Bilirubin ◽  
Common Method ◽  
Biliary Decompression ◽  
Tube Drainage ◽  
T Tube ◽  
Common Presentation ◽  
Tertiary Center ◽  
Malignant Group ◽  
Cbd Exploration

Abstract Introduction Obstructive jaundice is associated with high morbidity and mortality. Obstructive jaundice is not a definitive diagnosis. Detailed evaluation to establish the etiology of the cholestasis and cause of obstruction is crucial to avoid secondary pathologic changes and to plan different surgical techniques to intervene at an early stage. Materials and Methods A cross-sectional study was conducted among 50 cases of surgical obstructive jaundice at Shri Ram Murti Smarak Institute of Medical Sciences (SRMSIMS), Bareilly. Results The mean age of this study population was 48.44 ± 8.2 years, and 48% (24) patients had obstructive jaundice of benign etiology, whereas 52% (26) had malignant etiology. Among males, the common presentation was choledocholithiasis in benign disease and carcinoma of the gallbladder among malignancy. In females also, disease presentation was similar to that of males. Percutaneous transhepatic biliary drainage (PTBD) was the most common method of biliary decompression in malignant group. For biliary decompression in patients of benign etiology, common bile duct (CBD) exploration with T-tube drainage was done in most cases. Conclusion Obstructive jaundice has different etiologic spectrum in both males and females. Irrespective of etiology, common presentation was pain (94% of the cases). Most patients with malignant etiology presented with palpable lump. PTBD was the most common method of biliary decompression in malignant group. CBD exploration with T-tube drainage has higher values of decrease in serum bilirubin, serum bilirubin (indirect), serum alkaline phosphatase, and albumin.

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