scholarly journals Preliminary In vivo evaluation of the acute toxicity of Dillenia philippinensis (Rolfe) fruit extract, anthocyanins and polyphenols in Mice (Mus musculus)

2017 ◽  
Vol 10 (05) ◽  
pp. 51-65
Keyword(s):  
Acute Toxicity ◽  
Mus Musculus ◽  
Fruit Extract ◽  
In Vivo Evaluation

Design, synthesis and in vivo evaluation of sodium 2-benzyl-chloromalonates as new central nervous system depressants

MedChemComm ◽  
2015 ◽  
Vol 6 (8) ◽  
pp. 1427-1437 ◽  
Author(s):  
Andreia Aguiar Vieira ◽  
Bruno Guimarães Marinho ◽  
Luana Gonçalves de Souza ◽  
Patricia Dias Fernandes ◽  
José D. Figueroa-Villar
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Toxicity ◽  
Sleep Deprivation ◽  
High Solubility ◽  
In Vivo Evaluation ◽  
Design Synthesis ◽  
Solubility In Water ◽  
Low Levels

This work describes the design, synthesis and in vivo evaluation of new central nervous system depressing agents that show low levels of acute toxicity, high solubility in water, anxiolytic and hypnotic effects without sleep deprivation.

scholarly journals IN VIVO ANTI-DIABETIC ACTIVITY EVALUATION OF THE BARK OF CASCABELA THEVETIA L. IN STREPTOZOTOCIN INDUCED DIABETIC RATS

2017 ◽  
Vol 9 (6) ◽  
pp. 48
Author(s):  
Neelutpal Gogoi ◽  
Biman Bhuyan
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Acute Toxicity ◽  
Biochemical Parameters ◽  
Density Lipoprotein ◽  
Negative Control ◽  
Antidiabetic Activity ◽  
In Vivo Evaluation ◽  
Acute Toxicity Study

Objective: In this study, the plant Cascabela thevetia L. was selected based on ethnomedicinal documentation reports for evaluation of the antidiabetic activity. The aim of this study was to carry out acute toxicity study and in vivo evaluation of antidiabetic activity in an animal model.Methods: Firstly direct extraction of the dried bark powder was done with methanol using soxhlet apparatus. After collecting the extract, acute toxicity study was performed according to OECD (Organization for Economic Cooperation and Development) guideline 425. For in vivo evaluation of antidiabetic activity, streptozotocin (STZ) and nicotinamide induced type 2 diabetic male rat model was used. Six groups containing six animals in each were taken for the in vivo study and marked as normal control, standard control, negative control and test controls. For all the animals body weight, body temperature, blood glucose levels were determined at an interval of 5 d. After 15 d of treatment different biochemical parameters like triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), alkaline phosphatase level (ALP), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), total protein were determined and the results were evaluated by statistically using one-way analysis of variance (ANOVA). On the 15th day, all the animals were sacrificed and histopathological study of pancreases tissue was done.Results: The effects of the test extracts in lowering the blood glucose level and maintaining other biochemical parameters in the test groups were compared with the effect of standard drug metformin hydrochloride, 10 mg/kg body weight treated group and negative control group. The data were statistically evaluated using one-way analysis of variance (ANOVA) followed by Dunnet comparison all vs control method and taking significant at p<0.01. By comparing different biochemical parameters and histoarchitecture of the different test groups of animals, it was found that group V treated with 200 mg/kg body weight shows a significant effect.Conclusion: After performing the experiment it was found that the bark of Cascabela thevetia L. has the potential for blood glucose lowering activity and able to control abnormal lipids and enzymes level in blood. Further isolation of the compounds can lead to finding out the exact compound responsible for the activity.  

In vivo evaluation of acute toxicity of water-soluble carbon nanotubes

2011 ◽  
Vol 93 (3) ◽  
pp. 603-615 ◽  
Author(s):  
Han Li ◽  
Tao Zhang ◽  
Geyu Liang ◽  
Yanqiu Zhang ◽  
Xikai Wang
Keyword(s):  
Carbon Nanotubes ◽  
Acute Toxicity ◽  
Water Soluble ◽  
In Vivo Evaluation ◽  
Soluble Carbon

scholarly journals In vivo Evaluation and in silico Prediction of the Toxicity of Drepanoalpha Hard capsules

2020 ◽  
Author(s):  
Benjamin Gbolo Zoawe ◽  
Jean-Paul Ngbolua Koto-te-Nyiwa ◽  
Damien Tshibangu Sha-Tshibey ◽  
Patrick Memvanga Bondo ◽  
Dorothee Tshilanda Dinangayi ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Blood Cells ◽  
Guinea Pigs ◽  
Lethal Dose ◽  
White Blood Cells ◽  
Normal Solution ◽  
Histopathological Study ◽  
Acute Administration ◽  
In Vivo Evaluation

This study was carried out in order to investigate the safety of Drepanoalpha hard hard capsules, a phytomedicine used for the management of sickle cell disease in the Democratic Republic of Congo by the acute and sub-acute administration in Guinea pigs. The hard capsules were dissolved in saline normal solution (NaCl 0.9 %). The animals were randomly selected, marked and divided into 2 groups of 5 animals each (3 males and 2 females) for acute toxicity and 4 groups of 3 animals each for sub-acute toxicity. Those received by gavage a single dose of 5000 mg/kg body weight (B.W.) of Drepanoalpha hard capsules for acute toxicity followed by 125 mg/Kg, 250 mg/Kg and 500 mg/Kg B.W. twice daily for 28 days for sub-acute toxicity and saline normal solution (NaCl 0.9 % solution as vehicle). Hematological, biochemical and histopathological analyses were performed and the behavior of the animals was observed after treatment. The results showed that 50 % of the lethal dose (LD50) is greater than 5000 mg/Kg B.W., and the relative weights of vital organs (kidney, liver, lungs, and heart) collected from Guinea pigs at the end of treatment on D14 (acute toxicity) and D28 (sub-acute toxicity) did not undergone significant changes (p>0.05). The results of haematological (Red Blood Cells, White Blood Cells, Haemoglobin, Haematocrit) and biochemical (ALT, AST, Albumin, Total Protein) tests did not show significant differences between the control and test groups at significance level (0.05 for acute toxicity), while the histopathological study revealed none damage to the various organs excised. In conclusion, the results confirm the safety of Drepanoalpha, as shown in previous studies with lyophilisate and decocate in rats and Guinea pigs. Keywords: Acute Toxicity, Sub-acute Toxicity, Hard Capsule, Drepanoalpha

Radiolabelling and in vivo evaluation of [11C]GSK215083 as potential PET radioligand for the 5-HT6 receptor in the porcine brain

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S598-S598 ◽  
Author(s):  
Laurent Martarello ◽  
Vincent J Cunningham ◽  
Julian C Matthews ◽  
Eugenii Rabiner ◽  
Steen Jakobsen ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Porcine Brain
Sign in / Sign up

Export Citation Format

Share Document