Reduction in Dietary Calcium/Phosphorus Ratio Reduces Bone Mass and Strength in Ovariectomized Rats Enhancing Bone Turnover

2005 ◽  
Vol 69 (10) ◽  
pp. 1970-1973 ◽  
Author(s):  
Moyuru KOSHIHARA ◽  
Ritsuko MASUYAMA ◽  
Mariko UEHARA ◽  
Kazuharu SUZUKI
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Dietary Calcium ◽  
Ovariectomized Rats ◽  
Calcium Phosphorus

Effects of tibolone or ee treatment on bone mass and bone turnover in mature ovariectomized rats

1996 ◽  
Vol 6 (S1) ◽  
pp. 210-210 ◽  
Author(s):  
AGH Ederveen ◽  
HJ Kloosterboer
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Ovariectomized Rats

Long-term minodronic acid (ONO-5920/YM529) treatment suppresses increased bone turnover, plus prevents reduction in bone mass and bone strength in ovariectomized rats with established osteopenia

Bone ◽  
2008 ◽  
Vol 43 (5) ◽  
pp. 894-900 ◽  
Author(s):  
Makoto Tanaka ◽  
Hiroshi Mori ◽  
Ryoji Kayasuga ◽  
Yasuo Ochi ◽  
Naoki Kawada ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Bone Strength ◽  
Ovariectomized Rats ◽  
Minodronic Acid

scholarly journals Association between dietary calcium and phosphorus intakes, dietary calcium/phosphorus ratio and bone mass in the Korean population

2014 ◽  
Vol 13 (1) ◽  
Author(s):  
Kyung-Jin Lee ◽  
Kyung-Soo Kim ◽  
Ha-Na Kim ◽  
Jin-A Seo ◽  
Sang-Wook Song
Keyword(s):  
Bone Mass ◽  
Dietary Calcium ◽  
Korean Population ◽  
Calcium Phosphorus ◽  
Calcium And Phosphorus

Bone turnover in growing pigs fed three levels of dietary calcium

2000 ◽  
Vol 80 (4) ◽  
pp. 547-557 ◽  
Author(s):  
Torben Larsen ◽  
José A. Fernández ◽  
Ricarda M. Engberg
Keyword(s):  
Bone Resorption ◽  
Bone Mass ◽  
Bone Turnover ◽  
Bone Development ◽  
Dietary Calcium ◽  
Growing Pigs ◽  
Morphometric Analyses ◽  
Medium Level ◽  
Cross Links ◽  
Carboxy Terminal

The effect of dietary calcium level on bone quality and quantity was evaluated in growing pigs by means of histomorphometric methods as well as basic bone parameters and chemical indicators of bone turnover in the blood. Thirty growing pigs were allocated to three levels of dietary calcium, 3.5, 9.4 and 16.4 g kg−1DM, respectively. Blood was drawn five times throughout 62 d and analyzed for Ca, P, hydroxyproline, alkaline phosphatase and 1-carboxy terminal telopeptide (1CTP). On days 50 and 60 of the experiment, oxytetracycline was injected i.m. and the animals were sacrificed on day 62. Transiliac bone samples were obtained, processed undecalcified and used in morphologic and morphometric analyses. Medium or high dietary calcium resulted in a higher retention of calcium, and more bone mass as indicated by a higher trabecular bone volume and a lower bone resorption. The mineral appositional rate in the bones was also higher in these groups, indicating a fast growth rate. Conversely, a low dietary calcium supply, resulted in lower overall calcium retention, lower bone mass, and a higher extent of resorption lacunae and osteoid extent and width. Higher remodeling activity and osteoid accumulation were due to deficient mineralization as indicated by a lower mineralization rate and prolonged mineralization lag time. Bone markers in the blood were only slightly affected by the dietary calcium differences. It was concluded that the medium level of dietary calcium was sufficient to sustain sound bone development. Key words: Histomorphometric analysis, bone formation, bone resorption, hydroxyproline, cross-links, mineralization

Effect of dietary calcium: Phosphorus ratio on bone mineralization and intestinal calcium absorption in ovariectomized rats

BioFactors ◽  
2004 ◽  
Vol 22 (1-4) ◽  
pp. 39-42 ◽  
Author(s):  
Moyuru Koshihara ◽  
Ritsuko Masuyama ◽  
Mariko Uehara ◽  
Kazuharu Suzuki
Keyword(s):  
Calcium Absorption ◽  
Bone Mineralization ◽  
Dietary Calcium ◽  
Intestinal Calcium Absorption ◽  
Ovariectomized Rats ◽  
Calcium Phosphorus

Bone Mass Changes In Vivo During the Entire Reproductive Cycle in Rats Feeding Different Dietary Calcium and Calcium/Phosphorus Ratio Content

2003 ◽  
Vol 73 (6) ◽  
pp. 594-600 ◽  
Author(s):  
S. Zeni ◽  
A. Weisstaub ◽  
S. Di Gregorio ◽  
P. Ronanre de Ferrer ◽  
M. L. de Portela
Keyword(s):  
Bone Mass ◽  
Reproductive Cycle ◽  
Dietary Calcium ◽  
Calcium Phosphorus

Avaliação da Eficácia da Administração de Dexametasona ou Metilprednisolona para Produzir Osteoporose em Ratas/ Evaluating the Effectiveness of Dexamethasone or Methylprednisolone to Produce Osteoporosis in Rats

2011 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nilo César do Vale Baracho ◽  
Alexandre Mata de Paula ◽  
Roberto Franzini Junior ◽  
Rogério Mariotto Bitetti da Silva ◽  
Bruno Appolari ◽  
...  
Keyword(s):  
Bone Mass ◽  
Disease Incidence ◽  
Public Health Problem ◽  
Bone Thickness ◽  
Good Marker ◽  
Significant Difference ◽  
Group Control ◽  
Successful Induction ◽  
Calcium Phosphorus ◽  
De Medicina

Introdução: A osteoporose é considerada um grave problema de saúde pública em todo o mundo. No Brasil ainda não há dados estatísticos sobre a real incidência desta doença. Os glicocorticóides representam uma classe de drogas muito usada, sendo que podem influenciar significativamente a massa óssea. Entretanto, após tratamento com glicocorticóides em ratos, esses podem ou não apresentar alterações na massa óssea. Objetivo: Avaliar a eficácia da administração de dexametasona ou metilprednisolona em produzir osteoporose em ratas. Métodos: Vinte e quatro ratas, oriundas do biotério da Faculdade de Medicina de Itajubá, foram utilizadas e divididas em três grupos: controle, metilprednisolona e dexametasona. Foram avaliados íons e proteínas totais sanguíneos e feita a análise histopatológica de tecido ósseo. Resultados e conclusão: Pela análise histológica da espessura trabecular óssea, houve redução da massa óssea dos grupos tratados com glicocorticóides em comparação com o grupo controle, evidenciando o sucesso da indução de osteoporose. Além disso, houve uma maior redução da massa óssea no grupo tratado com dexametasona, em comparação com o grupo tratado com metilprednisolona. A análise bioquímica de cálcio, fósforo, magnésio e proteínas totais não sofreram diferença significativa entres os grupos, não sendo um bom marcador para remodelamento ósseo e para diagnóstico de osteoporose.Evaluating the Effectiveness of Dexamethasone or Methylprednisolone to Produce Osteoporosis in RatsIntroduction: Osteoporosis is considered a serious public health problem in worldwide. In Brazil we do not have statistics on the real disease incidence. Glucocorticoids are a class of drugs widely used, and can significantly influence bone mass. However, after treatment with glucocorticoids in rats, these may or may not show changes in bone mass. Objective: Evaluating the effectiveness of dexamethasone or methylprednisolone to produce osteoporosis in rats. Methods: Twenty-four rats, originated from the vivarium of the Faculty of Medicine Itajubá were used and divided into three groups: control, methylprednisolone and dexamethasone. Ions was evaluated blood and histopathology of bone tissue. Results and conclusion: by histologic analysis of trabecular bone thickness, a reduction of the mass bone in the groups treated with glucocorticoids compared with the group control, demonstrating the successful induction of osteoporosis. Furthermore, there was a greater reduction in bone mass in the group treated with dexamethasone compared with the group treated with methylprednisolone. The analysis biochemistry of calcium, phosphorus, magnesium and total protein did not undergo significant difference among the groups, there is a good marker for bone remodeling and osteoporosis diagnosis.

scholarly journals THE EFFECT OF DIETARY CALCIUM, PHOSPHORUS, AND VITAMIN D ON THE UTILIZATION OF IRON

1943 ◽  
Vol 147 (1) ◽  
pp. 71-75
Author(s):  
Irvin Fuhr ◽  
H. Steenbock
Keyword(s):  
Vitamin D ◽  
Dietary Calcium ◽  
Calcium Phosphorus
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