Radiation Safety in Nuclear Medicine: Report I. Topical Problems

2021 ◽  
Vol 66 (1) ◽  
pp. 29-36
Author(s):  
Boris Narkevich
Keyword(s):  
Nuclear Medicine ◽  
Radionuclide Therapy ◽  
Radiation Safety ◽  
Current State ◽  
Radionuclide Diagnostics

The current state and prospects of ensuring radiation safety in the nuclear medicine divisions of Russia are analyzed. The literature data and the main results of our own research to ensure the radiation safety of patients, staff, caregivers and the environment in the departments of radionuclide diagnostics and radionuclide therapy are presented. The most important and requiring solutions to ensure radiation safety in nuclear medicine are considered.

scholarly journals Rhenium-188 Production in Hospitals, by W-188/Re-188 Generator, for Easy Use in Radionuclide Therapy

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Maria Argyrou ◽  
Alexia Valassi ◽  
Maria Andreou ◽  
Maria Lyra
Keyword(s):  
Nuclear Medicine ◽  
Radiation Dose ◽  
Radionuclide Therapy ◽  
Radiation Safety ◽  
Low Cost ◽  
High Energy ◽  
Therapeutic Applications ◽  
Total Radiation Dose ◽  
Absorbed Radiation Dose ◽  
Effective Penetration

Rhenium-188 (Re-188) is a high energy -emitting radioisotope obtained from the tungsten-188/rhenium-188 (W-188/Re-188) generator, which has shown utility for a variety of therapeutic applications in nuclear medicine, oncology, and interventional radiology/cardiology. Re-188 decay is accompanied by a 155 keV predominant energy -emission, which could be detected by -cameras, for imaging, biodistribution, or absorbed radiation dose studies. Its attractive physical properties and its potential low cost associated with a long-lived parent make it an interesting option for clinical use. The setup and daily use of W-188/Re-188 generator in hospital nuclear medicine departments are discussed in detail. The clinical efficacy, for several therapeutic applications, of a variety of Re-188-labeled agents is demonstrated. The high energy of the -emission of Re-188 is particularly well suited for effective penetration in solid tumours. Its total radiation dose delivered to tissues is comparable to other radionuclides used in therapy. Furthermore, radiation safety and shielding requirements are an important subject of matter. In the case of bone metastases treatment, therapeutic ratios are presented in order to describe the efficacy of Re-188 usage.

scholarly journals Actual problems of nuclear medicine in pediatrics (review)

2021 ◽  
Vol 30 (4) ◽  
pp. 69-84
Author(s):  
A.S. Krylov ◽  
◽  
B.Ya. Narkevich ◽  
A.D. Ryzhkov ◽  
◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Medical Procedures ◽  
Radionuclide Studies ◽  
Normative Documents ◽  
Current State ◽  
Optimal Value ◽  
Radiation Induced ◽  
Radionuclide Diagnostics ◽  
Psychological Features

On the basis of literature data and personal experience, the current state and prospects for the development of nuclear medicine in pediatrics are analyzed. The main directions of radionuclide diagnostics and radionuclide therapy in children are briefly considered. The importance of accu-rate determination of the optimal value of the activity of a specific radiopharmaceutical adminis-tered to a child, taking into account his body weight and the study protocol, was noted. A tendency for an increase in the radiation load on patients is shown due to the widespread introduction into clinical practice of hybrid installations for radionuclide studies, when using which the dose of in-ternal radiation from radiopharmaceuticals is supplemented by the dose of external radiation from X-ray CT. The need to take into account the risk of radiation-induced carcinogenesis in nu-clear medical procedures, the probability of which in children is significantly higher than in adults, is emphasized. The technological and psychological features of these procedures in children are discussed. The necessity of substantial revision of domestic normative documents regulating the use of means and methods of nuclear medicine in pediatrics has been substantiated.

scholarly journals Manual on the proper use of yttrium-90-labeled anti-P-cadherin antibody injection for radionuclide therapy in clinical trials

2019 ◽  
Vol 33 (11) ◽  
pp. 787-805 ◽  
Author(s):  
Makoto Hosono ◽  
Hideharu Ikebuchi ◽  
Seigo Kinuya ◽  
Sachiko Yanagida ◽  
Yoshihide Nakamura ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Nuclear Medicine ◽  
Radiation Protection ◽  
Radionuclide Therapy ◽  
Japanese Society ◽  
Radiation Safety ◽  
Japanese Version ◽  
Ministry Of Health ◽  
Safety Issues ◽  
Yttrium 90

Abstract We present the guideline for use of yttrium-90-labeled anti-P-cadherin antibody injection for radionuclide therapy in clinical trials on the basis of radiation safety issues in Japan. This guideline was prepared by a study supported by the Ministry of Health, Labour, and Welfare, and approved by the Japanese Society of Nuclear Medicine. Treatment using yttrium-90-labeled anti-P-cadherin antibody injection in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection shown here are considered internationally useful as well. Only the original Japanese version is the formal document.

Radiation Safety in Nuclear Medicine: Report II. Normative Documents

2021 ◽  
Vol 66 (6) ◽  
pp. 18-25
Author(s):  
Boris Narkevich
Keyword(s):  
Nuclear Medicine ◽  
Working Conditions ◽  
Radiation Safety ◽  
Normative Documents ◽  
Regulatory Documents ◽  
Current State ◽  
Nuclear Medicine Practice

The specifics of improving current regulatory acts on nuclear medicine under the conditions of the "regulatory guillotine" are considered. The current state of regulatory documentation on ensuring the radiation safety of patients, personnel, individuals from the population and the environment, as well as on assessing working conditions and pension provision for personnel of domestic nuclear medicine units, is analyzed. The presence of a large number of provisions that are scientifically unsubstantiated and inconsistent with international recommendations and many years of nuclear medicine practice is shown. A number of proposals have been developed to introduce appropriate amendments to regulatory documents intended for practical use after the end of the “regulatory guillotine”.

Bifunctional Chelators for Radiorhenium: Past, Present and Future Outlook

2022 ◽  
Author(s):  
Diana Melis ◽  
Andrew Burgoyne ◽  
Maarten Ooms ◽  
Gilles Gasser
Keyword(s):  
Nuclear Medicine ◽  
Cancer Treatment ◽  
Radionuclide Therapy ◽  
Targeted Radionuclide Therapy ◽  
Future Outlook ◽  
Bifunctional Chelators ◽  
Normal Tissues

Targeted radionuclide therapy (TRNT) is an ever-expanding field of nuclear medicine that provides a personalised approach to cancer treatment while limiting toxicity to normal tissues. It involves the radiolabelling of...

scholarly journals Assessment of radiation safety awareness among nuclear medicine nurses: a pilot study

2014 ◽  
Vol 546 ◽  
pp. 012015
Author(s):  
N A Yunus ◽  
M H R O Abdullah ◽  
M A Said ◽  
P E Ch'ng
Keyword(s):  
Nuclear Medicine ◽  
Pilot Study ◽  
Radiation Safety ◽  
Safety Awareness

Radiation safety in nuclear medicine

2001 ◽  
Vol 28 (7) ◽  
pp. 948-948
Author(s):  
J.A.J. Camps
Keyword(s):  
Nuclear Medicine ◽  
Radiation Safety
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