scholarly journals Actual problems of nuclear medicine in pediatrics (review)

2021 ◽  
Vol 30 (4) ◽  
pp. 69-84
Author(s):  
A.S. Krylov ◽  
◽  
B.Ya. Narkevich ◽  
A.D. Ryzhkov ◽  
◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Medical Procedures ◽  
Radionuclide Studies ◽  
Normative Documents ◽  
Current State ◽  
Optimal Value ◽  
Radiation Induced ◽  
Radionuclide Diagnostics ◽  
Psychological Features

On the basis of literature data and personal experience, the current state and prospects for the development of nuclear medicine in pediatrics are analyzed. The main directions of radionuclide diagnostics and radionuclide therapy in children are briefly considered. The importance of accu-rate determination of the optimal value of the activity of a specific radiopharmaceutical adminis-tered to a child, taking into account his body weight and the study protocol, was noted. A tendency for an increase in the radiation load on patients is shown due to the widespread introduction into clinical practice of hybrid installations for radionuclide studies, when using which the dose of in-ternal radiation from radiopharmaceuticals is supplemented by the dose of external radiation from X-ray CT. The need to take into account the risk of radiation-induced carcinogenesis in nu-clear medical procedures, the probability of which in children is significantly higher than in adults, is emphasized. The technological and psychological features of these procedures in children are discussed. The necessity of substantial revision of domestic normative documents regulating the use of means and methods of nuclear medicine in pediatrics has been substantiated.

scholarly journals Methods for modeling the kinetics of radiopharmaceuticals with iodine isotopes in nuclear medicine problems

2020 ◽  
Vol 61 (2) ◽  
pp. 108-124
Author(s):  
Alexander V. Matveev ◽  
Keyword(s):  
Nuclear Medicine ◽  
Kinetic Parameters ◽  
Quantitative Data ◽  
The Body ◽  
Pharmacokinetic Parameters ◽  
Model Parameters ◽  
Pharmacokinetic Models ◽  
Radionuclide Studies ◽  
Radionuclide Diagnostics ◽  
Kinetics Of

The paper considers modeling methods and develops a unified approach to the construction of mathematical models of the kinetics of radiopharmaceuticals with iodine isotopes in the human body during diagnostic and therapeutic procedures of nuclear medicine. Based on this approach, three- and four-compartment pharmacokinetic models were developed and corresponding calculation programs were created in the C++ programming language for processing and evaluating the results of radionuclide diagnostics and therapy. Various methods for identifying model parameters based on quantitative data from radionuclide studies of the functional state of vital organs are proposed. The results of pharmacokinetic modeling for radionuclide diagnostics of the liver, kidney, and thyroid using iodine-containing radiopharmaceuticals are presented and analyzed. Using clinical and diagnostic data, individual pharmacokinetic parameters of transport of different radiopharmaceuticals in the body (transport constants, half-life periods, maximum activity in the organ and the time of its achievement) were determined. It is shown that the pharmacokinetic characteristics for each patient are strictly individual and cannot be described by averaged kinetic parameters. Within the framework of three pharmacokinetic models, “Activity-time” relationships were obtained and analyzed for different organs and tissues, including for tissues in which the activity of a radiopharmaceutical is impossible or difficult to measure by clinical methods. Also discussed are the features and the results of simulation and dosimetric planning of radioiodine therapy of the thyroid gland. It is shown that the values of absorbed radiation doses are very sensitive to the kinetic parameters of the compartment model. Therefore, special attention should be paid to obtaining accurate quantitative data from ultrasound and thyroid radiometry and identifying simulation parameters based on them. The work is based on the principles and methods of pharmacokinetics. For the numerical solution of systems of differential equations of the pharmacokinetic models we used Runge-Kutta methods and Rosenbrock method. The Hooke-Jeeves method was used to find the minimum of a function of several variables when identifying modeling parameters.

Radiation Safety in Nuclear Medicine: Report II. Normative Documents

2021 ◽  
Vol 66 (6) ◽  
pp. 18-25
Author(s):  
Boris Narkevich
Keyword(s):  
Nuclear Medicine ◽  
Working Conditions ◽  
Radiation Safety ◽  
Normative Documents ◽  
Regulatory Documents ◽  
Current State ◽  
Nuclear Medicine Practice

The specifics of improving current regulatory acts on nuclear medicine under the conditions of the "regulatory guillotine" are considered. The current state of regulatory documentation on ensuring the radiation safety of patients, personnel, individuals from the population and the environment, as well as on assessing working conditions and pension provision for personnel of domestic nuclear medicine units, is analyzed. The presence of a large number of provisions that are scientifically unsubstantiated and inconsistent with international recommendations and many years of nuclear medicine practice is shown. A number of proposals have been developed to introduce appropriate amendments to regulatory documents intended for practical use after the end of the “regulatory guillotine”.

Radiation Safety in Nuclear Medicine: Report I. Topical Problems

2021 ◽  
Vol 66 (1) ◽  
pp. 29-36
Author(s):  
Boris Narkevich
Keyword(s):  
Nuclear Medicine ◽  
Radionuclide Therapy ◽  
Radiation Safety ◽  
Current State ◽  
Radionuclide Diagnostics

The current state and prospects of ensuring radiation safety in the nuclear medicine divisions of Russia are analyzed. The literature data and the main results of our own research to ensure the radiation safety of patients, staff, caregivers and the environment in the departments of radionuclide diagnostics and radionuclide therapy are presented. The most important and requiring solutions to ensure radiation safety in nuclear medicine are considered.

Review of the Current State and Future Development in Standardizing Natural Lighting in Interiors

2018 ◽  
pp. 5-26 ◽  
Author(s):  
Stanislav Darula
Keyword(s):  
Human Life ◽  
Natural Light ◽  
Artificial Lighting ◽  
Computer Tools ◽  
Natural Lighting ◽  
Current State ◽  
Minimum Requirements ◽  
Life On Earth ◽  
Window Design

Three elements mainly wind, water and sun seemed to determine in ancient ages the basic phenomena of life on Earth. Architectural history documented the importance of sun influence on urban and building construction already in layouts of Mesopotamian and Greek houses. Not only sun radiation but especially daylight played a significant role in the creation of indoor environment. Later, in the 20th century, a search of interaction between human life in buildings and natural conditions were studied considering well­being and energy conscious design recently using computer tools in complex research and more detail interdisciplinary solutions. At the same time the restricted daytime availability of natural light was supplemented by more efficient and continually cheaper artificial lighting of interiors. There are two main approaches to standardize the design and evaluation of indoor visual environment. The first is based on the determination of the minimum requirements respecting human health and visibility needs in all activities while the second emphasizes the behaviour and comfort of occupants in buildings considering year­around natural changes of physical quantities like light, temperature, noise and energy consumption. The new current standardization basis for daylight evaluation and window design criteria stimulate the study of methodology principles that historically were based on the overcast type of sky luminance pattern avoiding yearly availability of sky illuminance levels. New trends to base the daylight standardization on yearly or long­term availability of daylight are using the averages or median sky illuminance levels to characterise local climatological conditions. This paper offers the review and discussion about the principles of the natural light standardization with a short introduction to the history and current state, with a trial to focus on the possible development of lighting engineering and its standards in future.

Disability as a social phenomenon

2020 ◽  
pp. 22-38
Author(s):  
Natalia Guseva ◽  
Vitaliy Berdutin
Keyword(s):  
Social Protection ◽  
Russian Society ◽  
Stage Model ◽  
High Quality ◽  
Rehabilitation Programs ◽  
Current State ◽  
The Social ◽  
Consistent Solution ◽  
First Time

At present, the problem of establishing disability is a point at issue in Russia. Despite the fact that medical criteria for disability are being developed very actively, high-quality methods for assessing social hallmarks are still lacking. Since disability is a phenomenon inherent in any society, each state forms a social and economic policy for people with disabilities in accordance with its level of development, priorities and opportunities. We have proposed a three-stage model, which includes a system for the consistent solution of the main tasks aimed at studying the causes and consequences of the problems encountered today in the social protection of citizens with health problems. The article shows why the existing approaches to the determination of disability and rehabilitation programs do not correspond to the current state of Russian society and why a decrease in the rate of persons recognized as disabled for the first time does not indicate an improvement in the health of the population. The authors proposed a number of measures with a view to correcting the situation according to the results of the study.

Integrative Approach in Law Understanding: the History of the Origin of Ideas and the Current State

2020 ◽  
Vol 2 (1) ◽  
pp. 115-130
Author(s):  
R. R. Palekha ◽  
Keyword(s):  
Central Place ◽  
Scientific Basis ◽  
Integrative Approach ◽  
Current State ◽  
History Of ◽  
Legal Thinking ◽  
Reliable Knowledge ◽  
The Right ◽  
Fat Formulation

Introduction. Right understanding is the most live, interesting and, at the same time, the uncertain and changeable area of researches which takes the central place as in the general theory of the right, and gains the increasing value in industry jurisprudence that is connected with its considerable teoretiko-methodological and applied potential which is shown in spheres of lawmaking and law-enforcement activity. Thus, right understanding represents research tools of the subject of knowledge which allow to study all range legal and, the based on them, state phenomena for the purpose of obtaining reliable knowledge of state and legal reality. In this regard integrative approach in right understanding which has rich history of the formation and development is of special interest, allows to perceive the right as integrally complete phenomenon, as much as possible retrieves its regulatory abilities and, provides achievement of criteria of scientific research: comprehensiveness, objectivity, historicism. Materials and Methods. In article an attempt of the analysis of integrative approach in right understanding from a position of history of origin of his ideas and assessment of the current state is made. A result of studying of scientific literature, generalization and comparison of the different points of view fat formulation of author’s determination of category “right understanding” and submission of the evidence-based integrative theory of right understanding which as much as possible conforms to requirements of time and has essential regulatory and guarding potential. Results. In article the category right understanding is comprehensively considered, different integrative theories of right understanding from a position of their origin and development are submitted, the value of modern integrative approach in right understanding is shown, perspectives of its further development are evaluated. Discussion and Conclusion. The author comes to the conclusion about the theoretical and methodological consistency and inevitability of the integrative approach in law understanding, which acts as a scientifically grounded type of legal thinking capable of comprehending the law on a truly scientific basis.

scholarly journals Influence of a Natural Plant Antioxidant on the Ageing Process of Ethylene-norbornene Copolymer (Topas)

2021 ◽  
Vol 22 (8) ◽  
pp. 4018
Author(s):  
Anna Masek ◽  
Angelika Plota
Keyword(s):  
Mechanical Properties ◽  
Food Packaging ◽  
Colour Change ◽  
Good Alternative ◽  
Plant Origin ◽  
Aging Behavior ◽  
Current State ◽  
Ft Ir ◽  
Potential Use

In the field of polymer technology, a variety of mainly synthetic additives are used to stabilize the materials during processing. However, natural compounds of plant origin can be a green alternative to chemicals such as synthetic polyphenols. An analysis of the effect of hesperidin on the aging behavior of ethylene-norbornene copolymer was performed. The evaluation of changes in the tested samples was possible by applying the following tests: determination of the surface energy and OIT values, mechanical properties analysis, colour change measurements, FT-IR and TGA analyses. The obtained results proved that hesperidin can be effectively used as natural stabilizer for polymers. Furthermore, as a result of this compound addition to Topas-silica composites, their surface and physico-mechanical properties have been improved and the resistance to aging significantly increased. Additionally, hesperidin can act as a dye or colour indicator and only few scientific reports describe a possibility of using flavonoids to detect changes in products during their service life, e.g., in food packaging. In the available literature, there is no information about the potential use of hesperidin as a stabilizer for cycloolefin copolymers. Therefore, this approach may contribute not only to the current state of knowledge, but also presents an eco-friendly solution that can be a good alternative to synthetic stabilizers.

scholarly journals EANM position paper on the role of radiobiology in nuclear medicine

2021 ◽  
Author(s):  
An Aerts ◽  
Uta Eberlein ◽  
Sören Holm ◽  
Roland Hustinx ◽  
Mark Konijnenberg ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Absorbed Dose ◽  
Added Value ◽  
External Irradiation ◽  
Executive Summary ◽  
Dose Rates ◽  
Biological Responses ◽  
Medical Physicists ◽  
Radiation Induced

Executive SummaryWith an increasing variety of radiopharmaceuticals for diagnostic or therapeutic nuclear medicine as valuable diagnostic or treatment option, radiobiology plays an important role in supporting optimizations. This comprises particularly safety and efficacy of radionuclide therapies, specifically tailored to each patient. As absorbed dose rates and absorbed dose distributions in space and time are very different between external irradiation and systemic radionuclide exposure, distinct radiation-induced biological responses are expected in nuclear medicine, which need to be explored. This calls for a dedicated nuclear medicine radiobiology. Radiobiology findings and absorbed dose measurements will enable an improved estimation and prediction of efficacy and adverse effects. Moreover, a better understanding on the fundamental biological mechanisms underlying tumor and normal tissue responses will help to identify predictive and prognostic biomarkers as well as biomarkers for treatment follow-up. In addition, radiobiology can form the basis for the development of radiosensitizing strategies and radioprotectant agents. Thus, EANM believes that, beyond in vitro and preclinical evaluations, radiobiology will bring important added value to clinical studies and to clinical teams. Therefore, EANM strongly supports active collaboration between radiochemists, radiopharmacists, radiobiologists, medical physicists, and physicians to foster research toward precision nuclear medicine.

Current State of Legislation, Law Enforcement and Judicial Practice in the Sphere of Conclusion, Modification and Termination of Lease Agreements for Land Plots, Concluded for Construction Purposes

2020 ◽  
Vol 1 ◽  
pp. 16-23
Author(s):  
V. V. Cheremukhin ◽  
Keyword(s):  
Law Enforcement ◽  
System Analysis ◽  
Legal Regulation ◽  
Scientific Development ◽  
Synthesis System ◽  
Judicial Practice ◽  
Current State ◽  
General Scientific ◽  
Statistical Indicators

Construction, as a sphere of the national economy, has impressive statistical indicators, determining the importance and relevance of its proper legal regulation, especially in terms of land use for relevant purposes. This article discusses the current situation in the sphere of provision of land plots for construction purposes, further alteration and termination of the relevant lease relations; provides a detailed analysis of the current legislation, law enforcement and judicial practice in such sphere. The purpose of the article is to analyze and summarize legislation judicial and law enforcement practice in this area, as well as the development of specific directions for a comprehensive dissertation research, proposals for improving the legislation regulating these relations. This goal is achieved by solving tasks such as studying of the existing legal regulation of disputed legal relations, law enforcement and judicial practice, identification of problematic and conflict-of-laws issues in the field under consideration, review of the degree of scientific development of the research topic, determination of trends in the development of this sphere of legal relations, development of specific proposals for changing legislation and law enforcement practice. General scientific (synthesis, system analysis, analogy) and special (formal-legal, comparative-legal) methods are used to solve the above problems. Based on the results of consideration of these issues, the author formulates the main problems of the legal relations under consideration, an assessment of the current degree of scientific development of this field is given, the main directions of the planned scientific research are also outlined, proposals are formulated to improve legislation and law enforcement practice.

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