scholarly journals ABNORMALITY OF LIPID METABOLISM IN PATIENTS WITH DIABETES MELLITUS TYPE 1 AND POOR GLYCEMIC CONTROL WITH AND WITHOUT DIABETIC MICROANGIOPATHIES

2016 ◽  
Vol 1 (6) ◽  
pp. 113-117
Author(s):  
Хамнуева ◽  
Larisa Khamnueva ◽  
Съемщиков ◽  
Vladimir Syomshchikov ◽  
Чугунова ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Glycemic Control ◽  
Disease Risk ◽  
Microvascular Complications ◽  
Cardiovascular Disease Risk ◽  
Poor Glycemic Control ◽  
High Density Lipoproteins ◽  
Very Low Density Lipoproteins

Hyperglycemia and dyslipidemia are common metabolic abnormalities in adults with type 1 diabetes mellitus (T1DM) and both increase cardiovascular disease risk. Normalization of lipid metabolism is a mandatory element in preven-tion of diabetic micro- and macroangiopathies in patients with T1DM and it is directly related to improvement of health outcome. We aimed to investigate serum lipid profiles in patients with T1DM and poor glycemic control. Among observed patients with T1DM, 76% were classified as having dyslipidemia, dyslipidemia rate was higher in patients with diabetic microangiopathies. Patients with T1DM and microvascular complications, arterial hypertension (AH) and the level of glycated hemoglobin (HbA1c) >8% had significantly higher levels of total cholesterol (TC), very low density lipoproteins (VLDL), triglycerides (TG) and non-high density lipoproteins (non-HDL). Therefore, management of patients with T1DM at the outpatient stage requires a strict control of lipid metabolism.

Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control

2014 ◽  
Vol 16 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Thanh Nguyen ◽  
Joyce Obeid ◽  
Rachel G Walker ◽  
Matthew P Krause ◽  
Thomas J Hawke ◽  
...  
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Poor Glycemic Control

scholarly journals Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus

2018 ◽  
Vol 8 (2) ◽  
pp. 110-116
Author(s):  
Emina Panjeta ◽  
Radivoj Jadrić ◽  
Mirsad Panjeta ◽  
Jozo Ćorić ◽  
Amela Dervišević
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Lipid Profile ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Poor Glycemic Control ◽  
Atherogenic Index ◽  
High Density Lipoproteins ◽  
Good Glycemic Control

Introduction: Diabetes mellitus type 2 has become a global health-care problem of modern society due to a pronounced increase of prevalence to pandemic proportions and vascular complications. At present, glycated hemoglobin (HbA1c) is widely accepted as a measure of glycemic control in established diabetes. The aim of this study was to analyze the lipid profile in serum of patients with diabetes mellitus type 2, and its relationship with HbA1c levels. Methods: The observational cross-sectional study included 60 diabetic patients, 30 men, and 30 women, age 32–94 years. Patients were assigned into two groups based on HbA1c values; Group 1: HbA1c ≤ 7% (good glycemic control) and Group 2: HbA1c > 7% (poor glycemic control). We analyzed the concentration of glucose, HbA1c, and lipid profile including total cholesterol levels, triglycerides (TAG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). Results: Significantly lower values of glucose concentration, TAG and the ratio TAG/HDLc were obtained in the group of patients with good glycemic control. (p < 0.0005) Patients with good glycemic control had lower values of Castelli 1 and Castelli 2 index, and atherogenic index of plasma, compared to patients with poor glycemic control, but this difference was not significant. (p > 0.005) Our study revealed a significant positive correlation between HbA1c and triglyceride level (r = 0.375; p = 0.003) and HbA1c and ratio triglyceride/HDLc (r = 0.335; p = 0.009). Conclusion: HbA1c can also be used as a predictor of dyslipidemia in type 2 diabetics in addition to as a glycemic control parameter.

scholarly journals Diabetic Myonecrosis: Uncommon Complications in Common Diseases

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Sisira Sran ◽  
Manpreet Sran ◽  
Nicole Ferguson ◽  
Prachi Anand
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Antiphospholipid Syndrome ◽  
Ischemia Reperfusion ◽  
Microvascular Complications ◽  
Poor Glycemic Control ◽  
Thigh Pain ◽  
Muscle Infarction ◽  
Common Diseases

We report a case of sudden thigh pain from spontaneous quadriceps necrosis, also known as diabetic myonecrosis, in a 28-year-old patient with poorly controlled diabetes mellitus. Diabetic muscle infarction is a rare end-organ complication seen in patients with poor glycemic control and advanced chronic microvascular complications. Proposed mechanisms involve atherosclerotic microvascular occlusion, ischemia-reperfusion related injury, vasculitis with microthrombi formation, and an acquired antiphospholipid syndrome. Diabetic myonecrosis most commonly presents as sudden thigh pain with swelling and should be considered in any patient who has poorly controlled diabetes mellitus.

scholarly journals Fibrinogen and Factor VII Levels Improve With Glycemic Control in Patients With Type 1 Diabetes Mellitus Who Have Microvascular Complications

2001 ◽  
Vol 161 (1) ◽  
pp. 98 ◽  
Author(s):  
John A. D'Elia ◽  
Larry A. Weinrauch ◽  
Ray E. Gleason ◽  
Izabela Lipinska ◽  
Joanne Keough ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Factor Vii

scholarly journals Correlation of C-Peptide and HbA1c in Type II Diabetes Mellitus

2021 ◽  
Vol 8 (6) ◽  
pp. 297-303
Author(s):  
V. Aruna
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Poor Glycemic Control ◽  
Diabetic Patients ◽  
C Peptide ◽  
Lipid Parameters

Type 2 Diabetes Mellitus (Non Insulin Dependent Diabetes Mellitus -NIDDM) is a chronic metabolic disorder most prevalent in India with microvascular complications. Several studies were underway to identify biomarkers to detect complications associated with increasing duration of disease. The present study was done to understand the role of Connecting peptide (C-peptide) in pathogenesis of microvascular changes and it’s correlation to dyslipidemia of T2DM. The study was done at Government General Hospital, Guntur. In this study 61 known T2 DM patients and 51 age sex matched controls were selected. Their fasting blood samples were analysed for FBS, HbA1C, Urea, Creatinine, Total Cholesterol, High Density Lipoprotein Cholesterol and C-peptide. Dyslipidemia was not observed in Diabetic patients compared to controls (TC, HDLC & NonHDL p = 0.363, 0.294 & 0.336 respectively). HbA1C and C-peptide showed significant correlation between cases and controls (P = <0.00001). C-peptide showed significant correlation with lipid parameters & lipid ratios in individuals with poor glycemic control identified by HbA1c value of >9%. (ANOVA p = <0.0001) Pearson’s correlation showed negative relation of HbA1c and C-peptide with lipid parameters TC, HDLC & Non HDLC (r = 0.378, 0.732, 0.313 and 0.81, 0.91 & 0.843 consecutively). C-peptide showed significant variation with Non HDL / HDL ratio & Non HDL / TC ratio (p = <0.002 & <0.00007) in diabetic patients with poor glycemic control identified by HbA1c of > 9%. We conclude that C-peptide would be a good marker to assess degree of function of pancreas and predictor of atherogenic complication in longstanding NIDDM. Keywords: Type 2 Diabetes Mellitus, C-peptide, HbA1c, Atherogenesis.

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