scholarly journals Diabetic Myonecrosis: Uncommon Complications in Common Diseases

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Sisira Sran ◽  
Manpreet Sran ◽  
Nicole Ferguson ◽  
Prachi Anand
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Antiphospholipid Syndrome ◽  
Ischemia Reperfusion ◽  
Microvascular Complications ◽  
Poor Glycemic Control ◽  
Thigh Pain ◽  
Muscle Infarction ◽  
Common Diseases

We report a case of sudden thigh pain from spontaneous quadriceps necrosis, also known as diabetic myonecrosis, in a 28-year-old patient with poorly controlled diabetes mellitus. Diabetic muscle infarction is a rare end-organ complication seen in patients with poor glycemic control and advanced chronic microvascular complications. Proposed mechanisms involve atherosclerotic microvascular occlusion, ischemia-reperfusion related injury, vasculitis with microthrombi formation, and an acquired antiphospholipid syndrome. Diabetic myonecrosis most commonly presents as sudden thigh pain with swelling and should be considered in any patient who has poorly controlled diabetes mellitus.

scholarly journals Diabetic Myonecrosis: Rare Complication of a Common Disease

2018 ◽  
Vol 8 (3) ◽  
pp. 263-265
Author(s):  
Muhammad Saiful Islam ◽  
Rafi Nazrul Islam ◽  
Mohammad Sakhawat Hossen Khan ◽  
Wasim Md Mohosin Ul Haque ◽  
Mohammad Ashraful Islam
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Antiphospholipid Syndrome ◽  
Clinical Presentation ◽  
Ischemia Reperfusion ◽  
Rare Complication ◽  
Microvascular Complications ◽  
Left Thigh ◽  
Common Disease ◽  
Adductor Muscles

We report a case of sudden left thigh pain in adductor muscles of medial compartment, known as diabetic myonecrosis, in a 50-year-old patient with poorly controlled diabetes mellitus. Diabetic muscle infarction is a rare end-organ complication seen in patients with poor glycemic control and advanced chronic microvascular complications. Proposed mechanisms involve atherosclerotic microvascular occlusion, ischemia-reperfusion related injury, vasculitis with microthrombi formation, and an acquired antiphospholipid syndrome. The clinical presentation is swelling, pain, and tenderness of the involved muscle, most commonly the thigh muscles. Management consists of conservative measures including analgesia and rest.Birdem Med J 2018; 8(3): 263-265

scholarly journals ABNORMALITY OF LIPID METABOLISM IN PATIENTS WITH DIABETES MELLITUS TYPE 1 AND POOR GLYCEMIC CONTROL WITH AND WITHOUT DIABETIC MICROANGIOPATHIES

2016 ◽  
Vol 1 (6) ◽  
pp. 113-117
Author(s):  
Хамнуева ◽  
Larisa Khamnueva ◽  
Съемщиков ◽  
Vladimir Syomshchikov ◽  
Чугунова ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Glycemic Control ◽  
Disease Risk ◽  
Microvascular Complications ◽  
Cardiovascular Disease Risk ◽  
Poor Glycemic Control ◽  
High Density Lipoproteins ◽  
Very Low Density Lipoproteins

Hyperglycemia and dyslipidemia are common metabolic abnormalities in adults with type 1 diabetes mellitus (T1DM) and both increase cardiovascular disease risk. Normalization of lipid metabolism is a mandatory element in preven-tion of diabetic micro- and macroangiopathies in patients with T1DM and it is directly related to improvement of health outcome. We aimed to investigate serum lipid profiles in patients with T1DM and poor glycemic control. Among observed patients with T1DM, 76% were classified as having dyslipidemia, dyslipidemia rate was higher in patients with diabetic microangiopathies. Patients with T1DM and microvascular complications, arterial hypertension (AH) and the level of glycated hemoglobin (HbA1c) >8% had significantly higher levels of total cholesterol (TC), very low density lipoproteins (VLDL), triglycerides (TG) and non-high density lipoproteins (non-HDL). Therefore, management of patients with T1DM at the outpatient stage requires a strict control of lipid metabolism.

scholarly journals Correlation of C-Peptide and HbA1c in Type II Diabetes Mellitus

2021 ◽  
Vol 8 (6) ◽  
pp. 297-303
Author(s):  
V. Aruna
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Poor Glycemic Control ◽  
Diabetic Patients ◽  
C Peptide ◽  
Lipid Parameters

Type 2 Diabetes Mellitus (Non Insulin Dependent Diabetes Mellitus -NIDDM) is a chronic metabolic disorder most prevalent in India with microvascular complications. Several studies were underway to identify biomarkers to detect complications associated with increasing duration of disease. The present study was done to understand the role of Connecting peptide (C-peptide) in pathogenesis of microvascular changes and it’s correlation to dyslipidemia of T2DM. The study was done at Government General Hospital, Guntur. In this study 61 known T2 DM patients and 51 age sex matched controls were selected. Their fasting blood samples were analysed for FBS, HbA1C, Urea, Creatinine, Total Cholesterol, High Density Lipoprotein Cholesterol and C-peptide. Dyslipidemia was not observed in Diabetic patients compared to controls (TC, HDLC & NonHDL p = 0.363, 0.294 & 0.336 respectively). HbA1C and C-peptide showed significant correlation between cases and controls (P = <0.00001). C-peptide showed significant correlation with lipid parameters & lipid ratios in individuals with poor glycemic control identified by HbA1c value of >9%. (ANOVA p = <0.0001) Pearson’s correlation showed negative relation of HbA1c and C-peptide with lipid parameters TC, HDLC & Non HDLC (r = 0.378, 0.732, 0.313 and 0.81, 0.91 & 0.843 consecutively). C-peptide showed significant variation with Non HDL / HDL ratio & Non HDL / TC ratio (p = <0.002 & <0.00007) in diabetic patients with poor glycemic control identified by HbA1c of > 9%. We conclude that C-peptide would be a good marker to assess degree of function of pancreas and predictor of atherogenic complication in longstanding NIDDM. Keywords: Type 2 Diabetes Mellitus, C-peptide, HbA1c, Atherogenesis.

scholarly journals Correlation between atherogenic factors in complicated and uncomplicated type 2 diabetes mellitus

2020 ◽  
Vol 7 (7) ◽  
pp. 1083
Author(s):  
Rajdeepak V. S. ◽  
Rekha G. ◽  
Jayashree S. C.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
Glucose Production ◽  
Poor Glycemic Control ◽  
Complications Of Diabetes

Background: Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. The factors contributing to hyperglycemia include reduced insulin secretion, decreased glucose utilization and increased glucose production. The vascular complications of DM are subdivided into microvascular (retinopathy, neuropathy, nephropathy) and macrovascular complications (coronary artery disease, peripheral vascular disease, cerebrovascular disease). There is an observed disparity between various vascular complications of diabetes and the atherogenic factors.Methods: The patients with type 2 diabetes mellitus attending outpatient and inpatient departments in Dr. B. R. Ambedkar Medical College and hospital, from September 2014 to September 2016 were selected for this study. All patients were subjected to detailed history, physical examination and laboratory investigations with respect to complications of diabetes mellitus.Results: In this study, 76% of the patients had poor glycemic control with elevated HbA1c >7%. 38% of patients had normal BMI. 36% of patients were overweight and 26% were obese. 62% of patients were either overweight or obese. Hypercholesterolemia was seen in 26% of patients with poor glycemic control. Hyperhomocysteinemia was present in 38% of patients with microvascular complications and 33% of patients with macrovascular complications.Conclusions: Type 2 diabetes mellitus showed a strong correlation between glycemic status and incidence of diabetes complications. Hypercholesterolemia and hyperhomocysteinemia have added to the increased incidence of complications as additional factors in metabolic derangements as a consequence of poor glycemic control.

Poor Glycemic Control Induces Hypertension in Diabetes Mellitus

Hypertension ◽  
1996 ◽  
Vol 27 (3) ◽  
pp. 735-739 ◽  
Author(s):  
Michael W. Brands ◽  
Timothy E. Hopkins
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Poor Glycemic Control

scholarly journals Diabetes Complications and their Relation to Glycemic Control among Patients Attending Diabetic Clinic at King Khalid National Guard Hospital in Jeddah, Saudi Arabia

2011 ◽  
Vol 1 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Abdullah M. Krawagh ◽  
Abdullah M. Alzahrani ◽  
Tariq A. Naser
Keyword(s):  
Diabetes Mellitus ◽  
Saudi Arabia ◽  
Heart Disease ◽  
Glycemic Control ◽  
Ischemic Heart Disease ◽  
National Guard ◽  
Microvascular Complications ◽  
Ischemic Heart ◽  
Diabetic Clinic

This study addresses the prevalence of ischemic heart disease, hypertension and long-term complications of diabetes mellitus among patients attending the diabetic clinic and their relation to glycemic control. Methods: A study was conducted on a cross-section on all consecutive patients attending the diabetic clinic at King Khalid National Guard Hospital in Jeddah, Saudi Arabia, from January 2007 to January 2008. The degree of glycemic control was gauged using blood level of glycosylated hemoglobin (HbA1C) and classified into good (less 7%), fair (7.1-8%), poor (8.1-9%) and very poor (greater than 9%). All patients were screened for hypertension, ischemic heart disease and microvascular complications. Results: Two hundred and ten patients were recruited in the study. Glycemic control was good in 17 (8.1%), fair in 49 (23.2%), poor in 56 (26.6%) and very poor in 88 (41.9%). There was high prevalence of retinopathy (76; 36%), microalbuminuria (80; 37.9%), neuropathy (108; 51.2%) and ischemic heart disease (51; 24.2%), especially among patients with poor and very poor control. Although the presence of hypertension, frank nephropathy and peripheral vascular disease was also disturbingly high among diabetic patients, their frequency was the same among good, fair, poor and very poor glycemic control groups. Conclusion: The prevalence of long-term complications of diabetes mellitus was alarmingly high among Saudi nationals. Microvascular complications and ischemic heart disease were also noticed to be more common in diabetics with poor and very poor glycemic control. This emphasizes the need of national awareness program about the gravity of the problem.

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