scholarly journals CORRELATION OF CHANGES OF ω-6 POLYUNSATURATED FATTY ACIDS AND FREE RADICAL PROCESSES IN ERYTHROCYTE MEMBRANES OF UMBILICAL CORD OF NEWBORNS WITH CYTOMEGALOVIRUS INFECTION

2017 ◽  
Vol 1 (3) ◽  
pp. 29-32 ◽  
Author(s):  
Ишутина ◽  
Nataliya Ishutina ◽  
Дорофиенко ◽  
Nikolay Dorofienko
Keyword(s):  
Fatty Acids ◽  
Free Radical ◽  
Polyunsaturated Fatty Acids ◽  
Umbilical Cord ◽  
Cytomegalovirus Infection ◽  
Erythrocyte Membranes ◽  
Free Radical Processes ◽  
Radical Processes

scholarly journals The effect of fenofibrate on expression of genes involved in fatty acids beta-oxidation and associated free-radical processes

2016 ◽  
Vol 62 (4) ◽  
pp. 426-430 ◽  
Author(s):  
A.P. Gureev ◽  
M.L. Shmatkova ◽  
V.Yu. Bashmakov ◽  
A.A. Starkov ◽  
V.N. Popov
Keyword(s):  
Fatty Acids ◽  
Free Radical ◽  
Metabolic Diseases ◽  
The Body ◽  
Antioxidant Systems ◽  
Peroxisome Proliferator ◽  
Ros Production ◽  
Free Radical Processes ◽  
Wide Range ◽  
Radical Processes

Fenofibrate is a synthetic ligand for peroxisome proliferator-activated receptors subtype alpha (PPARa); it is used for the treatment of a wide range of metabolic diseases such as hypertriglyceridemia, dyslipidemia, diabetes and various neurodegenerative diseases. We have studied the effect of fenofibrate on b-oxidation of fatty acids and related free-radical processes. The most effective concentration of fenofibrate (0.3%) added to the chow caused a significant decrease of the body weight of mice. The data obtained by quantitative PCR demonstrated increased hepatic gene expression responsible for b-oxidation of fatty acids in peroxisomes and mitochondria. Enhancement of oxidative processes caused a 2-fold increase in the rate of reactive oxygen species (ROS) production, as evidenced by determination of the level of lipid peroxidation (LPO) products in the liver. Mitochondrial antioxidant systems are more sensitive to elevated ROS production, as they respond by increased expression of SOD2 and PRDX3 genes, than cytoplasmic and peroxisomal antioxidant systems, where expression of CAT1, SOD1, PRDX5 genes remained unaltered.

scholarly journals Effects of low power laser radiation of blue, green and red ranges on free radical processes in rat blood in endotoxic shock

2013 ◽  
Vol 59 (4) ◽  
pp. 411-424 ◽  
Author(s):  
T.V. Machneva ◽  
N.V. Kosmacheva ◽  
Yu.A. Vladimirov ◽  
A.N. Osipov
Keyword(s):  
Free Radical ◽  
Laser Radiation ◽  
Low Power ◽  
Endotoxic Shock ◽  
Green Laser ◽  
Erythrocyte Membranes ◽  
Power Laser ◽  
Blood Leukocytes ◽  
Free Radical Processes ◽  
Radical Processes

This study was performed to investigate the effects of low power laser radiation in blue (441.2 nm), green (532.5 nm) and red (632.8 nm) wavelength ranges on free radical processes in experimental endotoxic shock in rats. The experimental model was produced by intraperitoneal injection of lipopolysacharide B (25 mg/kg) (LPS). The following parameters were assayed in the study: the chemiluminescent assay (to evaluate the free radical production by blood leukocytes), nitro blue tetrazolium assay (to monitor the superoxide dismutase activity of plasma) and cis -parinaric acid fluorescence (to estimate the intensity of lipid peroxidation in erythrocyte membranes). It was found that the low power laser radiation significantly influenced all investigated processes, in animals both treated and untreated without LPS injection. The most pronounced effects were observed in all groups of animals subjected to the low power laser radiation: at the dose of 0.75 J/cm2 green laser was most effective and at the dose of 1.5 J/cm2 green and red lasers provided maximal effects. The mechanisms of the observed phenomena are discussed.

Adaptogenic correction of free radical brain damage in subchronic exposure to sodium fl uoride

2020 ◽  
pp. 381-386
Author(s):  
A. G. Zhukova ◽  
L. G. Gorokhova ◽  
A. S. Kazitskaya ◽  
T. K. Yadykina ◽  
N. N. Mikhailova ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Free Radical ◽  
Brain Tissue ◽  
Free Radical Oxidation ◽  
Radical Oxidation ◽  
Free Radical Processes ◽  
Subchronic Exposure ◽  
Antioxidant Defense Enzymes ◽  
Radical Processes ◽  
Complex Drug

Introduction. Fluorine compounds in small doses, but with prolonged exposure, cause various disorders in organs at the cellular and molecular levels. Activation of free-radical processes plays an important role in the damaging eff ect of fl uorides. Th erefore, one of the most eff ective ways to limit fl uorine-induced damage is to directly aff ect free-radical processes using herbal preparations with antioxidant properties.The aim of the study is to study the eff ect of a dihydroquercetin-based drug on the activity of free radical processes in brain tissue under subchronic exposure to sodium fl uoride (NaF).Materials and methods. Th e work was performed on white male laboratory rats weighing 200-250 g. Th e rats were divided into 3 groups: 1 — control; 2 — rats with chronic exposure to sodium fl uoride (NaF) for 9 weeks; 3 — rats receiving a NAF solution with simultaneous administration of a complex drug based on dihydroquercetin at a dose of 3 mg/kg in 1% starch gel for 3, 6 and 9 weeks. The activity of free radical oxidation and antioxidant defense enzymes — superoxide dismutase (SOD) and catalase-was determined in the cerebral cortex. Th e level of expression of hypoxia-induced transcription factor HIF — 1A and inducible forms of proteins HSP72 and HSP32 were determined in the cytosolic fraction of brain tissue.Results. In the early stages of subchronic fl uoride exposure (1-3 weeks), the expression of protective proteins HIF-1α, HSP72, HSP32 and catalase was shown in the rat cortex, as a result of which the activity of free-radical processes was maintained at the control level. An increase in the timing of fl uoride intake to 9 weeks led to a decrease in antioxidant protection and signifi cant activation of free radical oxidation in brain tissue. Daily administration of a complex drug with dihydroquercetin for 3, 6 and 9 weeks to rats with subchronic fl uoride exposure led to a decrease in the severity of pro- and antioxidant balance disorders in the cerebral cortex. At the same time, the greatest protective eff ect of dihydroquercetin with fl uoride exposure was manifested by the 9th week of its administration.Conclusions. When subchronic intake of fl uorides in the body, the drug based on dihydroquercetin has a neuroprotective eff ect, which is manifested by an increase in the activity of antioxidant enzymes of fr ee radical oxidation and catalase and the resistance of the cortex to induced fr ee radical oxidation.

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