scholarly journals The benefits of vitamin D3 supplementation for menopausal women - literature review

2021 ◽  
Vol 11 (6) ◽  
pp. 47-51
Author(s):  
Katarzyna Cyboran ◽  
Monika Kuc ◽  
Jakub Lis ◽  
Damian Machaj ◽  
Jakub Polak

Witamina D to potoczna nazwa cholekalcyferolu i ergokalcyferolu. Występuje w postaci nieaktywnej, ale w wyniku hydroksylacji w pozycji 1 lub 25 staje się witaminą aktywną. Cholekalcyferol paszy z nieaktywnej formy pod wydanie UV w ciało ciało, natomiast ergosterol jest dostarczany do organizmu z pożywienia roślinnego. Witamina D ma znaczący wpływ na zdrowie kobiet po menopauzie. Poziom estrogenu spada u kobiety w okresie menopauzy. Ma to konsekwencje m.in. ubytki wapnia. To jest powód, dla którego kobiety w tym wieku znajduje się w grupie ryzyka zachorowania na osteoporozę. Witamina D pomaga w przyswajaniu wapnia i fosforu. Te minerały pełnią wolę wolę w okresie menopauzy.Kobiety w tej grupie wiekowej przyjmować od 1000 do 1500 mg dziennie. Nie zaleca się nadmiernego spożycia, przekroczenie normy nie przynosi lepszych efektów. Mimo to wykrycie niedoboru witaminy D u kobiet po menopauzie i rozpoczęcie leczenia pozytywnie wpływ na ich stan zdrowia. [1]

2020 ◽  
Vol 10 (5) ◽  
pp. 118
Author(s):  
Dominik Machaj ◽  
Katarzyna Cyboran ◽  
Alicja Płaczek ◽  
Marlena Baran ◽  
Michał Wojnowski

Author(s):  
Jean-Philippe Bonjour ◽  
Flore Dontot-Payen ◽  
Emilien Rouy ◽  
Stephane Walrand ◽  
Brigitte Rousseau

A 24 week-controlled trial was conducted in menopausal women (mean age:61.5) to assess serum 25-hydroyvitaminD (s25OHD) evolution in relation to three interdependent determinants: doses of supplemented (Suppl.) vitamin D3 (VitD3); baseline status; seasonality. Participants were randomized into 3 groups (Gr): Gr.Suppl.0, time-controls maintaining dietary habits; Gr.Suppl.5 and Gr.Suppl.10 consuming one and two 125 g servings of VitD3-fortified yogurts with 5 and 10 µg daily doses, respectively. The 16 intervention-weeks lasted from early-January to mid-August, the 8 follow-up-weeks from late-August to mid-October. Before enrollment, subjects were randomized into two s25OHD strata: “Low stratum (LoStr)“: 25-50 nmol/L; “High stratum (HiStr)“: >50-75 nmol/L. All enrolled participants remained compliant until study end: Gr.Suppl.0 (n=45), Gr.Suppl.5 (n=44) Gr.Suppl.10 (n=44). Over the 16 intervention and 8 follow-up weeks, s25OHD increased in both supplemented groups, more in Gr.Suppl.10 than Gr.Suppl.5. The constant rate of s25OHD per supplemental VitD3 microgram was greater in LoStr than HiStr. s25OHD increase was greater with late (mid-March) than early (mid-January) inclusion. In conclusion, this randomized trial demonstrates: -a dose-dependent s25OHD improvement related to fortified yogurt consumption; -an inversely baseline-dependent increase in s25OHD; -a seasonal effect that highlights the importance of vitamin D3 supplementation during winter, even at 5µg/d, in healthy menopausal women.


2018 ◽  
Vol 3 (3) ◽  
pp. 75-81 ◽  
Author(s):  
I.M. Madaeva ◽  
◽  
N.V. Semenova ◽  
V.A. Astafyev ◽  
E.B. Druzhinina ◽  
...  

GYNECOLOGY ◽  
2015 ◽  
Vol 17 (1) ◽  
pp. 34-40
Author(s):  
E.N. Andreeva ◽  
◽  
O.R. Grigoryan ◽  
Yu.S. Absatarova ◽  
◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1408
Author(s):  
Hermann Brenner ◽  
Sabine Kuznia ◽  
Clarissa Laetsch ◽  
Tobias Niedermaier ◽  
Ben Schöttker

Meta-analyses of randomized controlled trials (RCTs) have demonstrated a protective effect of vitamin D3 (cholecalciferol) supplementation against cancer mortality. In the VITAL study, a RCT including 25,871 men ≥ 50 years and women ≥ 55 years, protective effects of vitamin D3 supplementation (2000 IU/day over a median of 5.3 years) with respect to incidence of any cancer and of advanced cancer (metastatic cancer or cancer death) were seen for normal-weight participants but not for overweight or obese participants. We aimed to explore potential reasons for this apparent variation of vitamin D effects by body mass index. We conducted complementary analyses of published data from the VITAL study on the association of body weight with cancer outcomes, stratified by vitamin D3 supplementation. Significantly increased risks of any cancer and of advanced cancer were seen among normal-weight participants compared to obese participants in the control group (relative risk (RR), 1.27; 95% confidence interval (CI), 1.07–1.52, and RR, 1.44; 95% CI, 1.04–1.97, respectively). No such patterns were seen in the intervention group. Among those with incident cancer, vitamin D3 supplementation was associated with a significantly reduced risk of advanced cancer (RR, 0.86; 95% CI, 0.74–0.99). The observed patterns point to pre-diagnostic weight loss of cancer patients and preventive effects of vitamin D3 supplementation from cancer progression as plausible explanations for the body mass index (BMI)—intervention interactions. Further research, including RCTs more comprehensively exploring the potential of adjuvant vitamin D therapy for cancer patients, should be pursued with priority.


2021 ◽  
pp. 1-14
Author(s):  
Elham Kazemian ◽  
Sayed Hossein Davoodi ◽  
Mohammad Esmaeil Akbari ◽  
Nariman Moradi ◽  
Safoora Gharibzadeh ◽  
...  

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