scholarly journals Prevention of Advanced Cancer by Vitamin D3 Supplementation: Interaction by Body Mass Index Revisited

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1408
Author(s):  
Hermann Brenner ◽  
Sabine Kuznia ◽  
Clarissa Laetsch ◽  
Tobias Niedermaier ◽  
Ben Schöttker

Meta-analyses of randomized controlled trials (RCTs) have demonstrated a protective effect of vitamin D3 (cholecalciferol) supplementation against cancer mortality. In the VITAL study, a RCT including 25,871 men ≥ 50 years and women ≥ 55 years, protective effects of vitamin D3 supplementation (2000 IU/day over a median of 5.3 years) with respect to incidence of any cancer and of advanced cancer (metastatic cancer or cancer death) were seen for normal-weight participants but not for overweight or obese participants. We aimed to explore potential reasons for this apparent variation of vitamin D effects by body mass index. We conducted complementary analyses of published data from the VITAL study on the association of body weight with cancer outcomes, stratified by vitamin D3 supplementation. Significantly increased risks of any cancer and of advanced cancer were seen among normal-weight participants compared to obese participants in the control group (relative risk (RR), 1.27; 95% confidence interval (CI), 1.07–1.52, and RR, 1.44; 95% CI, 1.04–1.97, respectively). No such patterns were seen in the intervention group. Among those with incident cancer, vitamin D3 supplementation was associated with a significantly reduced risk of advanced cancer (RR, 0.86; 95% CI, 0.74–0.99). The observed patterns point to pre-diagnostic weight loss of cancer patients and preventive effects of vitamin D3 supplementation from cancer progression as plausible explanations for the body mass index (BMI)—intervention interactions. Further research, including RCTs more comprehensively exploring the potential of adjuvant vitamin D therapy for cancer patients, should be pursued with priority.

Author(s):  
K. Subramanyam ◽  
Dr. P. Subhash Babu

Obesity has become one of the major health issues in India. WHO defines obesity as “A condition with excessive fat accumulation in the body to the extent that the health and wellbeing are adversely affected”. Obesity results from a complex interaction of genetic, behavioral, environmental and socioeconomic factors causing an imbalance in energy production and expenditure. Peak expiratory flow rate is the maximum rate of airflow that can be generated during forced expiratory manoeuvre starting from total lung capacity. The simplicity of the method is its main advantage. It is measured by using a standard Wright Peak Flow Meter or mini Wright Meter. The aim of the study is to see the effect of body mass index on Peak Expiratory Flow Rate values in young adults. The place of a study was done tertiary health care centre, in India for the period of 6 months. Study was performed on 80 subjects age group 20 -30 years, categorised as normal weight BMI =18.5 -24.99 kg/m2 and overweight BMI =25-29.99 kg/m2. There were 40 normal weight BMI (Group A) and 40 over weight BMI (Group B). BMI affects PEFR. Increase in BMI decreases PEFR. Early identification of risk individuals prior to the onset of disease is imperative in our developing country. Keywords: BMI, PEFR.


2021 ◽  
pp. 014556132098051
Author(s):  
Matula Tareerath ◽  
Peerachatra Mangmeesri

Objectives: To retrospectively investigate the reliability of the age-based formula, year/4 + 3.5 mm in predicting size and year/2 + 12 cm in predicting insertion depth of preformed endotracheal tubes in children and correlate these data with the body mass index. Patients and Methods: Patients were classified into 4 groups according to their nutritional status: thinness, normal weight, overweight, and obesity; we then retrospectively compared the actual size of endotracheal tube and insertion depth to the predicting age-based formula and to the respective bend-to-tip distance of the used preformed tubes. Results: Altogether, 300 patients were included. The actual endotracheal tube size corresponded with the Motoyama formula (64.7%, 90% CI: 60.0-69.1), except for thin patients, where the calculated size was too large (0.5 mm). The insertion depth could be predicted within the range of the bend-to-tip distance and age-based formula in 85.0% (90% CI: 81.3-88.0) of patients. Conclusion: Prediction of the size of cuffed preformed endotracheal tubes using the formula of Motoyama was accurate in most patients, except in thin patients (body mass index < −2 SD). The insertion depth of the tubes was mostly in the range of the age-based-formula to the bend-to-tip distance.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Louise Lundborg ◽  
Xingrong Liu ◽  
Katarina Åberg ◽  
Anna Sandström ◽  
Ellen L. Tilden ◽  
...  

AbstractTo evaluate associations between early-pregnancy body mass index (BMI) and active first stage labour duration, accounting for possible interaction with maternal age, we conducted a cohort study of women with spontaneous onset of labour allocated to Robson group 1. Quantile regression analysis was performed to estimate first stage labour duration between BMI categories in two maternal age subgroups (more and less than 30 years). Results show that obesity (BMI > 30) among younger women (< 30 years) increased the median labour duration of first stage by 30 min compared with normal weight women (BMI < 25), and time difference estimated at the 90th quantile was more than 1 h. Active first stage labour time differences between obese and normal weight women was modified by maternal age. In conclusion: (a) obesity is associated with longer duration of first stage of labour, and (b) maternal age is an effect modifier for this association. This novel finding of an effect modification between BMI and maternal age contributes to the body of evidence that supports a more individualized approach when describing labour duration.


Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2641 ◽  
Author(s):  
Rebeca Reyes-Garcia ◽  
Antonia Garcia-Martin ◽  
Santiago Palacios ◽  
Nancy Salas ◽  
Nicolas Mendoza ◽  
...  

Background: Milk products fortified with vitamin D may constitute an alternative to pharmacological supplements for reaching the optimal levels of serum 25-hydroxyvitamin D [25(OH)D]. Our aim was to analyze the response of serum 25(OH)D and its predictive factors in postmenopausal healthy women after a dietary intervention with a milk fortified with vitamin D and calcium. Methods: We designed a prospective study including 305 healthy postmenopausal women who consumed a fortified milk with calcium (900 mg/500 mL) and vitamin D3 (600 IU/500 mL) daily for 24 months. Results: The 25(OH)D concentrations at 24 months were correlated to weight, to body mass index, to the percentage of fat, triglycerides and to baseline 25(OH)D levels. We found significant differences in the levels of 25(OH)D at 24 months according to baseline 25(OH)D levels (p < 0.001) and body mass index (p = 0.019) expressed at quartiles. Multivariate analysis showed an association between levels of 25(OH)D after the intervention and at baseline 25(OH)D (Beta = 0.47, p < 0.001) and percentage of body fat (Beta = −0.227, p = 0.049), regardless of the body mass index. Conclusions: In healthy postmenopausal women, the improvement in 25(OH)D after an intervention with a fortified milk for 24 months depends mainly on the baseline levels of serum 25(OH)D and on the percentage of body fat.


Author(s):  
Rosalia Vazquez-Arevalo ◽  
Alberto Rodríguez Nabor ◽  
Xochitl López Aguilar ◽  
Juan Manuel Mancilla-Díaz

Abstract The objective of this research was to determine the body perception (BP) of preschoolers and compare it with the one reported by their parents. A total of 48 preschoolers participated (Mage = 5 years, SD = 0.5), 21 boys, 27 girls, and their parents (47 fathers and 48 mothers). The children were weighed and measured, also they answered the instrument Seven Figures of Collins (SFC) and seven questions about food, beauty and health. The parents answered the Body Image Questionnaire, the Stunkard Figures, as well as the SFCs to identify the real (RF) and ideal figure(IF) of their children. When children described themselves, they mostly referred the normal figure, coinciding with their parents. A very small proportion of preschoolers perceived themselves with obesity (around 29-30%); while any parent identified their children with obesity. 50% of preschoolers chose thinner silhouettes than their body mass index (BMI), but not emaciated. For RF, most parents chose normal weight for boys and light overweight for girls; for IF parents chose, for both sexes, the one with light overweight. In conclusion, the preschool BP disagreed between reality and perception, regardless of their BMI and gender. The parents also did not have an adequate BP for their children. Resumen El objetivo de esta investigación fue conocer la percepción corporal (PC) de preescolares y compararla con la que sus padres tienen de ellos. Participaron 48 preescolares (Medad = 5 años, DE = 0.5), 21 niños y 27 niñas, y sus padres (47 papás y 48 mamás). Los niños fueron pesados y medidos, contestaron el instrumento Siete Figuras de Collins (SFC) y, con relación a éste, siete preguntas sobre alimentación, belleza y salud. A los padres se les aplicó el Cuestionario de Imagen Corporal, las Figuras de Stunkard, además de las SFC para que identificaran la figura real (FR) e ideal (FI) de sus hijos. Para describirse, los preescolares refirieron mayormente la figura normopeso, coincidiendo con sus padres. Fue mínima la proporción de preescolares que se percibieron con obesidad (presente en 29-30%); mientras que ningún padre la identificó en sus hijos. El 50% de los preescolares eligió siluetas más delgadas a su índice de masa corporal (IMC), pero no emaciadas. Como FR, la mayoría de los padres eligió la normopeso para los niños y con sobrepeso ligero para las niñas; como FI eligieron, para ambos sexos, aquélla con sobrepeso ligero. En conclusión, la PC del preescolar discrepó entre la real y la percibida, independientemente de su IMC y sexo. Los padres tampoco tuvieron una adecuada PC de sus hijos.


2019 ◽  
Vol 75 (4) ◽  
pp. 231-237 ◽  
Author(s):  
Xiaomin Sun ◽  
Kumpei Tanisawa ◽  
Yuping Zhang ◽  
Tomoko Ito ◽  
Satomi Oshima ◽  
...  

Introduction: This study aimed to clarify whether 1 year of vitamin D3 supplementation has a direct effect on body composition and physical fitness in healthy adults. Methods: Ninety-five participants randomly received either 420 IU vitamin D3 per day (n = 48) or placebo (n = 47) in a double-blind manner for 1 year. Lean body mass and percentage body fat were determined. Physical fitness including hand grip strength, leg extension power and cardiorespiratory fitness (CRF) were assessed. Serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH]2D) concentrations were assessed using ELISA kits. Results: Serum 25(OH)D and (1,25[OH]2D) concentrations significantly increased by approximately 11.2 ± 9.2 ng/mL (pinteraction <0.001)and 7.0 ± 7.8 pg/mL (pinteraction <0.001) after 1 year of vitamin D3 supplementation respectively. Lean body mass significantly increased from 43.8 ± 9.6 to 44.3 ± 9.8 kg in vitamin D group, while no change was observed in placebo group (from 42.6 ± 8.9 to 42.4± 8.9 kg) after 1 year intervention. Furthermore, no treatment effects on other indicators of body composition and physical fitness were observed. Conclusions:One year of vitamin D supplementation effectively improves lean body mass, but not muscle strength and CRF in healthy adults.


2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6625-6625
Author(s):  
D. Gupta ◽  
K. Trukova ◽  
P. G. Vashi ◽  
A. Adams ◽  
G. M. Lambert ◽  
...  

6625 Background: The association between vitamin D and obesity remains unsettled with studies reporting conflicting findings on the relationship between the two. This association assumes even greater importance in cancer because of the alleged role of vitamin D in cancer risk and survival. Currently, the dietary recommendations for Vitamin D do not take into account a person's body mass index (BMI). We investigated the relationship between serum 25-hydroxy-vitamin D [25(OH)D] and BMI in a large sample of cancer patients. Methods: A consecutive case series of 740 cancer patients seen at Cancer Treatment Centers of America from Jan 08 to June 08. Serum 25(OH)D was measured at presentation to the hospital. The cohort was divided in 4 BMI groups (<18.5, 18.5–24.9, 25–29.9, and >30.0 kg/m2). Correlation between 25(OH)D and BMI was evaluated using Spearman correlation coefficient. Mean 25(OH)D was compared across the 4 BMI groups using ANOVA. Linear regression was used to quantify the relationship between BMI and 25(OH)D. Results: Of 740 patients, 303 were males and 437 females. The mean age at presentation was 55.7 years (SD = 10.2). The mean BMI was 27.9 kg/m2 (SD = 6.7). Most common cancers were lung (134, 18.1%), breast (131, 17.7%), colorectal (97, 13.1%), pancreas (86, 11.6%), prostate (45, 6.1%) and ovarian (39, 5.3%). The mean serum 25(OH)D was 21.9 ng/ml (SD = 13.5). Analysis revealed that as BMI groups increased from normal to overweight or obese classifications, there was a significant decrease in 25(OH)D (Table). The Spearman correlation between 25(OH)D and BMI was -0.20 (p = 0.001). Every 1 kg/m2 increase in BMI was significantly associated with a 0.43 ng/ml decline in serum 25(OH)D (p = 0.001). Conclusions: We found that obese cancer patients (BMI >=30 kg/m2) had significantly lower levels of serum 25(OH)D as compared to nonobese patients (BMI <30 kg/m2). BMI should be taken into account when assessing a patient's vitamin D status and more aggressive vitamin D supplementation should be considered in obese cancer patients. [Table: see text] No significant financial relationships to disclose.


2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 7060-7060
Author(s):  
Catherine Handy Marshall ◽  
Paul A McAuley ◽  
Hua-Ling Tsai ◽  
Zeina Dardari ◽  
Mouaz H Al-Mallah ◽  
...  

7060 Background: The obesity paradox –i.e. inverse associations between body mass index (BMI) and mortality – has been reported in patients with cancer, heart failure, and diabetes. However, the influence of cardiorespiratory fitness (CRF) on this relationship is not well established. This study assesses the association of BMI and CRF with all-cause mortality among cancer patients. Methods: The Henry Ford (HF) FIT Project is a retrospective cohort study of 69,885 consecutive patients who underwent physician-referred exercise stress testing from 1991 through 2009. Cancer diagnosis was identified through linkage to the HF tumor registry. We included patients 40-70 years old, with BMI recorded, at time of exercise test, with a history of cancer > 6 months prior. BMI was categorized as normal (18.5-24.9kg/m2), overweight (25-29.9kg/m2), or obese ( > = 30kg/m2). All-cause mortality was obtained from the National Death Index. Because of a significant interaction between BMI and cancer type, patients with breast or prostate cancer were excluded. Multivariable adjusted Cox proportional hazard models were used to evaluate the association of CRF andBMI with all-cause mortality; adjusted for age at exercise test, sex, diabetes, smoking, cancer stage, and time from cancer diagnosis to exercise test. Results: Included were 676 patients with a mean age of 58 years (SD 7.5), 51% female, 70% White, 25% Black, with a median of 4.8 years from diagnosis to exercise test and median follow up time of 10.3 years. Among patients achieving < 10 METs, those who are overweight and obese had a lower risk of mortality HR 0.47 (95% CI 0.25,0.86) and HR 0.44 (95% CI 0.26, 0.74, respectively), compared to those with normal BMI. Among patients with METs > = 10, those who were overweight had the lowest risk of all-cause mortality (HR 0.23, 95% CI 0.09-0.62) compared to normal weight, while no statistically significant different risk of mortality was observed when comparing those who are obese to normal weight (HR 0.37, 95% CI 0.13-1.06). In an analysis combining BMI and fitness groups (four categories), those with BMI > = 25 and METs > = 10 had the lowest risk of all-cause mortality (Table). Conclusions: In non-breast/non-prostate cancer patients, increased BMI is associated with improved overall survival in those with METs < 10, while a U-shaped relationship between BMI and all-cause mortality exists among those with METs > = 10. [Table: see text]


2016 ◽  
Vol 54 (3) ◽  
pp. 161-172 ◽  
Author(s):  
Teodora Gabriela Alexescu ◽  
Angela Cozma ◽  
Adela Sitar-Tăut ◽  
V. Negrean ◽  
M.I. Handru ◽  
...  

Abstract Background. Obesity and overweight are two pathologies that are more and more frequent in the XXIst century diagnosis and are causing high morbidity and mortality rates in the general population, especially through cardiovascular complications.Aims. Identification and early diagnosis of cardiac changes in overweight and obese patients. Material and method. We carried out a sectional, analytical and observational study on 111 subjects: 27 normal weight subjects and 84 overweight and obese patients, which were submitted to a clinical exam, biochemical exams and 2D ultrasound.Results. The presence of diastolic dysfunction is twice more frequent in overweight patients in comparison to normal weight ones (30% vs 15%) and 5 times more frequent in obese patients than normal weight ones (75% vs 15%). The size increase of the interventricular septum is correlated with the body mass index, there being statistically significant differences between normal weight vs overweight vs obese patients, as well as between overweight and obese ones. Within the whole group and within the groups, both the left ventricle mass (g) as well as the left ventricle mass to body surface ratio (g/m²) are statistically significantly higher in patients with present diastolic dysfunction (E/A < 1). This indicates a relation between the presence of diastolic dysfunction, increased left ventricle mass and body mass index (p < 0.05).Conclusions. Overweight and obese patients, unlike normal weight ones, present early cardiac changes, such as: a decrease of left ventricle ejection fraction, diastolic dysfunction, thickening of the interventricular septum, increase of the left ventricle mass both per se as well as in ratio to body surface.


2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Trigisa Lasabuda ◽  
Pemsi M. Wowor ◽  
Yanti Mewo

Abstract: Obesity is one manifestation of nutritional problems, which need attention. Obesity is a state of excess body fat in absolute terms and relative. In 2000, the Directorate of Community Nutrition Ministry of Health recorded a total population of Indonesia are categorized as obese estimated 76.7 million (17.5%). Many factors play a role in the occurrence of obesity are largely an interaction between genetic factors and environmental factors, such as physical activity, social, economic, and nutrition. The obesity increases the risk of cardiovascular disease because its related with the metabolic syndrome or insulin resistance syndrome or / hyperinsulinemia, glucose intolerance / diabetes mellitus (DM), dyslipidemia, hypertension and other. This study uses a quantitative research design and cross-sectional approach which takes place from July to August, 2015. The total sample of 20 people were taken to the al-Fatah mosque Malalayang aged 9-21 years. The results of the research showed that respondent with weight less amounted to 8 respondent, respondents with normal weight is 10 respondents and it was the highest, respondent with pre-obesity is only one respondent, while respondent with obesity II also only 1 respondents. Conclusion: The results of this study concluded that the image of the body mass index (BMI) mosque al - Fatah Malalayang respondents with less weight have percentage of 40%, respondents with normal weight have a percentage of 45%, respondents with more weight percentage of 15%, the respondents with pre-obese weight have percentage of 5%, and the respondent with weight obesity II have a percentage of 10%.Keywords: obesity, body mass index (BMI), diabetes mellitus (DM).Abstrak: Obesitas merupakan salah satu manifestasi dari masalah gizi lebih, yang perlu mendapatkan perhatian. Pada tahun 2000, Direktorat Bina Gizi Masyarakat Departemen Kesehatan RI mencatat jumlah penduduk Indonesia yang masuk kategori obesitas diperkirakan 76.7 juta (17.5%) . Banyak faktor yang berperan dalam terjadinya obesitas yang sebagian besar merupakan interaksi antara faktor genetik dengan faktor lingkungan, antara lain aktivitas fisik, sosial ekonomi, dan nutrisi. Keadaan obesitas meningkatkan risiko penyakit-penyakit kardiovaskular karena keterkaitanya dengan sindrom metabolik atau atau sindrom resistensi insulin/hiperinsulinemia, intoleransi glukosa/Diabetes Melitus (DM), dyslipidemia, hipertensi dan lainnya. Penelitian ini menggunakan desain penelitian kuantitatif dan pendekatan cross sectional yang berlangsung dari Juli – Agustus 2015. total sampel berjumlah 20 orang yang diambil pada jamaah Masjid Al- Fatah Malalayang yang berusia 19 – 21 tahun. Berdasarkan hasil penelitian didapatkan bahwa responden yang memiki berat badan kurang berjumlah 8 responden, responden dengan berat badan normal 9 responden dan merupakan yang terbanyak, responden dengan pra obesitas 1 responden, sedangkan responden dengan badan obesitas II 2 responden. Simpulan: Dari hasil penelitian dapat disimpulkan bahwa gambaran Indeks Massa tubuh (IMT) masjid al – fatah malalayang responden dengan berat badan kurang memiliki persentase sebesar 40%, responden dengan berat badan normal memiliki persentase sebesar 45%, responden dengan berat badan lebih memiliki persentase sebesar 15%, responden dengan berat badan pra obesitas memiliki persentase sebesar 5%, Responden dengan berat badan obesitas II memiliki persentase sebesar 10%.Kata kunci: obesitas, indeks massa tubuh (IMT), diabetes mellitus (DM).


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