Oro - Facial Manifestations , Oxidative Stress Marker and Antioxidant in Serum and Saliva of Patients with Beta Thalassemia Major

2015 ◽  
Vol 27 (2) ◽  
pp. 93-97
Author(s):  
Muaid S. Abbas Shamsah ◽  
Taghreed Fadhil Zaidan
Keyword(s):  
Oxidative Stress ◽  
Thalassemia Major ◽  
Oxidative Stress Marker ◽  
Beta Thalassemia ◽  
Stress Marker ◽  
Beta Thalassemia Major

scholarly journals Assessment of thiol/disulfide balance as an oxidative stress marker in children with β-thalassemia major

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Ahmet Guzelcicek ◽  
Gokhan Cakirca ◽  
Ozcan Erel ◽  
Abdullah Solmaz
Keyword(s):  
Oxidative Stress ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Oxidative Stress Marker ◽  
Creative Commons ◽  
Pediatric Hematology ◽  
Stress Marker ◽  
Oxidative Stress Status ◽  
Blood Specimens

Objective: We aimed to investigate the oxidative stress status in children with β-thalassemia major (β-TM) by measuring native thiol (SH), disulfide (SS) and total thiol (SH + SS) plasma levels. Methods: This study was carried out from November 2017 to March 2018 at the Pediatric Hematology Clinic of the Harran University Medical Faculty Hospital. Blood specimens were collected from 100 participants, including 50 β-TM patients and 50 controls, and SH, SS and SH+SS levels were detected through a newly developed method. Results: SH, SS, SH+SS levels and SS/SH ratio were markedly higher in β-TM patients than in controls. In β-TM group, SH and SH+SS levels were positively correlated with age, albumin and total bilirubin. Serum ferritin level was positively correlated with SH, SH+SS, aspartate transaminase and alanine transaminase. Conclusions: We found that the SS/SH ratio was high in patients with β-TM, which shows increased oxidative stress. This ratio may be considered as a tool for the determination of oxidative status in such patients due to easily calculate, suitable for routine use and economical. How to cite this:Guzelcicek A, Cakirca G, Erel O, Abdullah Solmaz4. Assessment of thiol/disulfide balance as an oxidative stress marker in children with β-thalassemia major. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.307 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients: A Review of the Literature

Anemia ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Q. Shazia ◽  
Z. H. Mohammad ◽  
Taibur Rahman ◽  
Hossain Uddin Shekhar
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Antioxidant Enzymes ◽  
Tissue Injury ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Trace Element Levels ◽  
Serum Trace Elements

Beta thalassemia major is an inherited disease resulting from reduction or total lack of beta globin chains. Patients with this disease need repeated blood transfusion for survival. This may cause oxidative stress and tissue injury due to iron overload, altered antioxidant enzymes, and other essential trace element levels. The aim of this review is to scrutinize the relationship between oxidative stress and serum trace elements, degree of damage caused by oxidative stress, and the role of antioxidant enzymes in beta thalassemia major patients. The findings indicate that oxidative stress in patients with beta thalassemia major is mainly caused by tissue injury due to over production of free radical by secondary iron overload, alteration in serum trace elements and antioxidant enzymes level. The role of trace elements like selenium, copper, iron, and zinc in beta thalassemia major patients reveals a significant change of these trace elements. Studies published on the status of antioxidant enzymes like catalase, superoxide dismutase, glutathione, and glutathione S-transferase in beta thalassemia patients also showed variable results. The administration of selective antioxidants along with essential trace elements and minerals to reduce the extent of oxidative damage and related complications in beta thalassemia major still need further evaluation.

scholarly journals Genetic Variation in SOD1Gene Promoter Ins/Del and Its Influence on Oxidative Stress in Beta Thalassemia Major Patients

2020 ◽  
Author(s):  
Poonam Tripathi ◽  
Sarita Agarwal ◽  
Aditya Narayan Sarangi
Keyword(s):  
Oxidative Stress ◽  
Human Peripheral Blood ◽  
In Silico Analysis ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Loss Of Function ◽  
Sod Activity ◽  
Beta Thalassemia Major ◽  
The Status ◽  
Polymerase Chain

Background: A genetic polymorphism of 50 bp insertion/deletion (Ins/Del) (rs 36232792) in the promoter region of the SOD1 was reported to influence the enzyme activity. The aims of the present study are to evaluate the status of this polymorphism on the SOD1 levels in human peripheral blood cells and its association with risk of oxidative stress in beta thalassemia major patients. Material and Methods: The study was carried out on 200 thalassemia major patients and 200 healthy controls healthy. The SOD1 genotypes were determined using a polymerase chain reaction (PCR)-based method. Serum SOD activity were assessed using SOD assay kit. In-silico analysis was assessed using loss-of-function (LofTool) (PMID: 27563026). Results: No association was found between the insertion/deletion (Ins/Del) polymorphism of SOD1 and risk of oxidative stress in thalassemia major patients Conclusion: The results of this study indicated that the oxidative stress is not affected by the Ins/ Del polymorphism of SOD1 in thalassemia major patients. Further research with larger sample size and with other genes of antioxidant system is required.

scholarly journals Oxidative stress and disturbance in antioxidant balance in beta thalassemia major

2008 ◽  
Vol 23 (4) ◽  
pp. 337-340 ◽  
Author(s):  
Rahul A. Ghone ◽  
K. M. Kumbar ◽  
A. N. Suryakar ◽  
R. V. Katkam ◽  
N. G. Joshi
Keyword(s):  
Oxidative Stress ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major

Ischemia modified albumin: An oxidative stress marker in β-thalassemia major

2012 ◽  
Vol 413 (9-10) ◽  
pp. 907-910 ◽  
Author(s):  
Samir M. Awadallah ◽  
Manar F. Atoum ◽  
Nisreen A. Nimer ◽  
Suleiman A. Saleh
Keyword(s):  
Oxidative Stress ◽  
Thalassemia Major ◽  
Oxidative Stress Marker ◽  
Ischemia Modified Albumin ◽  
Stress Marker

scholarly journals Beta-Thalassemia Major and Female Fertility: The Role of Iron and Iron-Induced Oxidative Stress

Anemia ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Paraskevi Roussou ◽  
Nikolaos J. Tsagarakis ◽  
Dimitrios Kountouras ◽  
Sarantis Livadas ◽  
Evanthia Diamanti-Kandarakis
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Tissue Injury ◽  
Hypogonadotropic Hypogonadism ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Number Of Patients ◽  
Endocrine Organs ◽  
Reproductive Techniques

Endocrine complications due to haemosiderosis are present in a significant number of patients with beta-thalassemia major (BTM) worldwide and often become barriers in their desire for parenthood. Thus, although spontaneous fertility can occur, the majority of females with BTM is infertile due to hypogonadotropic hypogonadism (HH) and need assisted reproductive techniques. Infertility in these women seems to be attributed to iron deposition and iron-induced oxidative stress (OS) in various endocrine organs, such as hypothalamus, pituitary, and female reproductive system, but also through the iron effect on other organs, such as liver and pancreas, contributing to the impaired metabolism of hormones and serum antioxidants. Nevertheless, the gonadal function of these patients is usually intact and fertility is usually retrievable. Meanwhile, a significant prooxidants/antioxidants imbalance with subsequent increased (OS) exists in patients with BTM, which is mainly caused by tissue injury due to overproduction of free radicals by secondary iron overload, but also due to alteration in serum trace elements and antioxidant enzymes. Not only using the appropriate antioxidants, essential trace elements, and minerals, but also regulating the advanced glycation end products, could probably reduce the extent of oxidative damage and related complications and retrieve BTM women’s infertility.

Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative stress as a novel promising treatment in children having beta-thalassemia major

2019 ◽  
Vol 16 ◽  
pp. 100245 ◽  
Author(s):  
Mohamed El-Shanshory ◽  
Nahed Mohammed Hablas ◽  
Moutasem Salih Aboonq ◽  
Ahmed R. Fakhreldin ◽  
Mohammed Attia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Iron Overload ◽  
Nigella Sativa ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Promising Treatment
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