Relation between Oxidative Stress and Carotid Intima-Media Thickness in Beta-Thalassemia Major Patients

2014 ◽  
Vol 17 (10.2014) ◽  
pp. 0-0
Keyword(s):  
Oxidative Stress ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Media Thickness

DETERMINANTS OF CAROTID INTIMA-MEDIA THICKNESS IN BETA-THALASSEMIA MAJOR

2008 ◽  
Vol 9 (1) ◽  
pp. 246
Author(s):  
A. Tavridou ◽  
A. Vryonidou ◽  
G. Karapostolakis ◽  
N. Giannoulakos ◽  
C. Phenekos ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Media Thickness

Interrelationship Of Oxidative Stress And Inflammatory State With Carotid Intima-Media Thickness

2019 ◽  
Vol 287 ◽  
pp. e175
Author(s):  
M. Janczura ◽  
T. Iwaniec ◽  
A. Gielicz ◽  
K. Kotula-Horowitz ◽  
A. Stanisz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Inflammatory State

scholarly journals Early detection of premature atherosclerosis in β-thalassemia patients by measuring carotid intima-media thickness

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
W E Ibrahim ◽  
O I Youssef ◽  
H G A Ali ◽  
D M A Alnagar
Keyword(s):  
Carotid Artery ◽  
Early Detection ◽  
Iron Overload ◽  
Lipid Profile ◽  
Intima Media Thickness ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Thalassemia Intermedia ◽  
Premature Atherosclerosis ◽  
Media Thickness

Abstract Background Beta-thalassemia patients still suffer from many complications. Transfused patients may develop complications related to iron overload including growth retardation and failure or delay of sexual maturation, cardiac involvement (dilated cardiomyopathy or rarely arrhythmia), liver (fibrosis and cirrhosis), endocrine glands (diabetes mellitus, hypogonadism, insufficiency of parathyroid, thyroid, pituitary and less commonly, adrenal glands). Purpose The present study was undertaken to evaluate the role of Carotid artery intima media thickness (CIMT) measurement as an early detector of premature atherosclerosis in beta-thalassemia children and early adolescents and its relation to biochemical risk factors as iron overload and lipid profile. Patients and Method Twenty-two β-thalassemia major (TM), 8 β-thalassemia intermedia (TI) with confirmed diagnosis of beta-thalassemia (major and intermedia) proved by clinical and laboratory investigations, frequent blood transfusion, chelation therapy with their age ranging from 10 to18 years old and 30 age-and sex matched healthy controls were included. Lipid profile (by colorimetric assay), serum ferritin, and CIMT measurements using high-resolution B-mode ultrasonography were estimated. Results CIMT of thalassemic patients (major and intermedia) was highly significantly increased compared to controls with no significant difference between β-thalassemia major and β thalassemia intermedia groups could be detected. CIMT was positively correlated with serum ferritin, TG, Total cholesterol level in both diseased groups and LDL level in B-TM group only. This provides a good evidence of the presence of premature atherosclerosis in vascular-free TM and TI patients and its relation to increased body iron and dyslipidemia. Conclusion Carotid artery intima media thickness represented a simple, accurate and non-invasive method for early detection of premature atherosclerosis which started early in β- thalassemia patients This study identified a relationship between body iron status, dyslipidemia and increased carotid IMT..

Are Uremia, Diabetes, and Atherosclerosis Linked With Impaired Antioxidant Mechanisms?

2008 ◽  
Vol 56 (2) ◽  
pp. 545-552 ◽  
Author(s):  
Belda Dursun ◽  
Evrim Dursun ◽  
Irfan Capraz ◽  
Tomris Ozben ◽  
Ali Apaydin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intima Media Thickness ◽  
Chronic Kidney Failure ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Carotid Imt ◽  
Accelerated Atherosclerosis ◽  
Media Thickness ◽  
Diabetes Status ◽  
Antioxidant Mechanisms

BackgroundOxidative stress is a new risk factor for atherosclerosis. Increased oxidative stress in hemodialysis (HD) patients may arise from uremia-associated metabolic/humoral abnormalities and bioincompatibility of dialysis. Patients with diabetes mellitus (DM) may be subject to an additional risk. Respective influences of uremia, diabetes, and HD duration in accelerated atherosclerosis and oxidative stress have not been clarified yet.MethodsThe study was performed on 24 nondiabetic HD patients, 23 diabetic HD patients, 20 stages 3 to 4 chronic kidney disease patients, and 21 diabetic patients without overt nephropathy. Carotid intima-media thickness, a surrogate of atherosclerosis, was measured by high-resolution B-mode ultrasonography. Oxidant status was determined by lipid peroxidation as expressed by malondialdehyde (MDA); antioxidant status was determined by superoxide dismutase, catalase, glutathione peroxidase, reduced intracellular glutathione, and plasma thiol.ResultsIntima-media thickness (IMT) was higher in patients undergoing HD but not different between nondiabetic HD patients and diabetic HD patients. No correlation was found between the duration of HD and intima-media thickness. Antioxidants were generally lower in HD patients. Intima-media thickness was positively correlated with MDA and negatively correlated with plasma thiol. Among other risk factors, only age was correlated with intima-media thickness.ConclusionsIncreased carotid IMT in HD patients is independent of duration of HD or diabetes status. Age and MDA are the significant predictors of carotid IMT. Increased oxidative stress due to impaired antioxidant mechanisms, particularly reduced plasma thiol redox potential, may account for accelerated atherosclerosis in high-risk patients with chronic kidney failure and/or DM.

scholarly journals A Pilot Study Providing Evidence for a Relationship between a Composite Lifestyle Score and Risk of Higher Carotid Intima-Media Thickness: Is There a Link to Oxidative Stress?

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Neda Seyedsadjadi ◽  
Jade Berg ◽  
Ayse A. Bilgin ◽  
Ross Grant
Keyword(s):  
Oxidative Stress ◽  
Cell Damage ◽  
Interleukin 1 ◽  
Antioxidant Properties ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Blood Collection ◽  
Lifestyle Behaviours ◽  
Media Thickness ◽  
Increased Risk

Lifestyle behaviours have been closely linked to the progressive cell damage associated with oxidative stress (OS) and the development of cardiovascular disease (CVD). Early detection of lifestyle-linked OS may therefore be useful in the early identification of prodromal disease. To test this hypothesis, this study assessed the relationship between a comprehensive redox balance lifestyle score (RBLS) and carotid intima-media thickness (CIMT), a recognized marker for CVD, and plasma biomarkers of OS. In a cross-sectional study design, 100 apparently healthy middle-aged participants were asked to complete a comprehensive lifestyle questionnaire, followed by DXA scanning, CIMT ultrasonography, and blood collection. The RBLS was composed of lifestyle components with pro- and antioxidant properties with a higher score indicative of lower oxidative activity. Multiple linear regression and logistic regression analysis were performed for statistical analysis. The RBLS was significantly associated with the risk for increased CIMT that was independent of conventional CVD risk factors (χ29=35.60,P≤0.001). The adjusted model explained 42.4% of the variance in CIMT. Participants with RBLS below the median were at significantly increased risk of higher CIMT compared to participants with RBLS above the median (OR=3.60, 95% CI: 1.19–10.88,P=0.023). Significant associations were also observed between the RBLS, plasma total antioxidant capacity (TAC) (r99=0.28,P=0.006), hydroperoxide (HPX) (rs99=−0.28,P=0.005), TAC/HPX ratio (r98=0.41,P≤0.001),γ-glutamyltransferase (r97=−0.23,P=0.024), uric acid (r98=−0.20,P=0.045), and inflammatory C-reactive protein (rs97=−0.25,P=0.012) and interleukin-1β(r97=−0.21,P=0.040). These findings highlight the importance of identifying the collective influence of lifestyle behaviours on OS activity and its potential to remodel the vascular endothelium.

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