The Ameliorative Effect of Cleome Droserifolia (Samwa) on Myocardial Injury Associated with Diabetes in Male Rats

2017 ◽  
Vol 69 (4) ◽  
pp. 2222-2231
Author(s):  
M. M. El-Komy ◽  
M. H. Serag ◽  
A. A. Emsalam
Keyword(s):  
Myocardial Injury ◽  
Male Rats ◽  
Ameliorative Effect

Ameliorative effect of Alpinia officinarum Hance extract on nonylphenol‐induced reproductive toxicity in male rats

Andrologia ◽  
2021 ◽  
Author(s):  
Marzieh Pirzadeh ◽  
Mohammad Barary ◽  
Seyed Mohammad Hosseini ◽  
Sohrab Kazemi ◽  
Ali Akbar Moghadamnia
Keyword(s):  
Reproductive Toxicity ◽  
Male Rats ◽  
Alpinia Officinarum ◽  
Ameliorative Effect

scholarly journals Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 682
Author(s):  
Yasmina K. Mahmoud ◽  
Ahmed A. Ali ◽  
Heba M. A. Abdelrazek ◽  
Tahany Saleh Aldayel ◽  
Mohamed M. Abdel-Daim ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Histopathological Examination ◽  
Memory Performance ◽  
Elevated Serum ◽  
Corticosterone Level ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Serum Corticosterone ◽  
Group I ◽  
Ameliorative Effect

The ameliorative effect of L-arginine (LA) and L-carnitine (LC) against fipronil (FPN)-induced neurotoxicity was explored. In this case, 36 adult male rats were randomly divided into six groups: group I received distilled water, group II received 500 mg/kg LA, group III received 100 mg/kg LC, group IV received 4.85 mg/kg FPN, group V received 4.85 mg/kg FPN and 500 mg/kg LA and group VI received 4.85 mg/kg FPN and 100 mg/kg LC for 6 weeks. Cognitive performance was assessed using Barnes maze (BM). Serum corticosterone, brain total antioxidant capacity (TAC), malondialdehyde (MDA) and dopamine were measured. Histopathology and immunohistochemistry of ionized calcium-binding adaptor (Iba-1), doublecortin (DCX) and serotonin (S-2A) receptors were performed. Fipronil induced noticeable deterioration in spatial learning and memory performance. In addition, FPN significantly (p < 0.05) diminished brain antioxidant defense system and dopamine coincide with elevated serum corticosterone level. Histopathological examination revealed degenerative and necrotic changes. Furthermore, Iba-1 and DCX were significantly expressed in cortex and hippocampus whereas S-2A receptors were significantly lowered in FPN group. However, administration of LA or LC alleviated FPN-induced deteriorations. In conclusion, LA and LC could be prospective candidates for mitigation of FPN-induced neurotoxicity via their antioxidant, anti-inflammatory and neuropotentiating effects.

Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats

2013 ◽  
Vol 30 (1) ◽  
pp. 26-43 ◽  
Author(s):  
Manar Hamed Arafa ◽  
Dalia AbdElmoain Mohamed ◽  
Hebatallah Husseini Atteia
Keyword(s):  
Pulmonary Toxicity ◽  
Male Rats ◽  
Ameliorative Effect ◽  
Acetyl Cysteine

Ameliorative effect of gallic acid on doxorubicin-induced cardiac dysfunction in rats

2018 ◽  
Vol 29 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Temiday O. Omóbòwálé ◽  
Ademola A. Oyagbemi ◽  
Ayorinde M. Folasire ◽  
Temitayo O. Ajibade ◽  
Ebunoluwa R. Asenuga ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Antineoplastic Agent ◽  
Male Rats ◽  
Protective Effects ◽  
Cardiac Damage ◽  
Antioxidant Defence ◽  
Defence System ◽  
Wistar Strain ◽  
Antioxidant Defence System ◽  
Ameliorative Effect

AbstractBackground:The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because of the myriad of toxic sequelae associated with it. The aim of this study was to assess the protective effects of gallic acid (GA) on DOX-induced cardiac toxicity in rats.Methods:Sixty male rats (Wistar strain) were used in this study. They were divided into six groups (A–F) each containing 10 animals. Group A was the control. Rats in Groups B, C, and D were treated with DOX at the dosage of 15 mg/kg body weight i.p. Prior to this treatment, rats in Groups C and D had been treated orally with GA for 7 days at the dosage of 60 and 120 mg/kg, respectively. Animals from Groups E and F received only 60 and 120 mg/kg GA, respectively, which were administered orally for 7 days.Results:The exposure of rats to DOX led to a significant (p<0.05) decrease in the cardiac antioxidant defence system and elevation of creatine kinase myocardial band and lactate dehydrogenase. The electrocardiography results showed a significant decrease in heart rate, QRS, and QT-segment prolongation. GA alone improved the antioxidant defence system.Conclusions:The GA pretreatment significantly alleviated GA-associated ECG abnormalities, restored the antioxidant status and prevented cardiac damage.

scholarly journals Selenium supplementation ameliorated paraquat-induced haemotoxicity in male rats

2020 ◽  
pp. 17-21
Keyword(s):  
Group Iv ◽  
Selenium Supplementation ◽  
Male Rats ◽  
Haematological Parameters ◽  
Group V ◽  
Once Daily ◽  
Group Iii ◽  
Group I ◽  
Ameliorative Effect ◽  
Haematological Changes

Introduction: The study was aimed at determining the haematological changes induced by 7 days paraquat exposure in rats and the ameliorative effect of selenium. Methods: Fifty-two adult male rats weighing between 150g and 200g were used for the study. The animals re randomly divided into five (5) groups of eight (8) rats each viz: Group I (DW) was administered distilled water only (2 ml/kg), group II (P1) was paraquat 15 mg/kg, group III (P1 + S) was paraquat (15 mg/kg) and selenium (0.3 mg/kg) an hour later, group IV (P2) was paraquat 30 mg/kg, while group V (P2 + S) was paraquat (30 mg/kg) and selenium (0.3 mg/kg) an hour later. Treatments were administered per os by gavage once daily for a week. Blood samples were analysed on the last day of administration. Results: The results of the study revealed that there were no significant differences (p >0.05) in haematological parameters in paraquat-induced toxicity in rats. Significance: The result of this research has shown that 7 days paraquat administration at 15 and 30 mg/kg has no detrimental effect on haematological parameters in rats, thus selenium supplementation cannot be justified to ameliorate its effect.

scholarly journals Effect of Tiger Nut Meal on Some Sex Hormones and Sperm Cells in Androgen-induced Benign Prostate Hyperplasia in Adult Male Wistar Rats

2020 ◽  
pp. 74-82
Author(s):  
D. I. Izunwanne ◽  
J. N. Egwurugwu ◽  
C. L. Emegano
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Semen Analysis ◽  
Reproductive Function ◽  
Reproductive Hormones ◽  
Male Rats ◽  
Estradiol Valerate ◽  
Sperm Cells ◽  
Prostate Hyperplasia ◽  
Ameliorative Effect ◽  
Benign Prostate

Introduction: It is generally believed that Cyperus esculentus (tiger nut) has some fertility boosting effects. However, scientific validation of some of the fertility boosting potentials as well as the ameliorative effect of tiger nut on Benign Prostate Hyperplasia (BPH) is lacking. Objective: The aim of the project is to determine the effect of tiger nuts in reproductive function in rats induced with Benign Prostate Hyperplasia (BPH). Methods: A total of sixty (60) male rats weighing between 160 – 200 g were used in this study. They were divided into six groups of ten rats per group. Benign prostate hyperplasia was induced in three groups of the rats (as stated in methodology) with 30 mg/kg sub-cutaneous injections of hormones containing dihydrotestosterone (DHT) and estradiol valerate dissolved in olive oil in the ratio of 10:1 (three times in a week, one day interval). Administration of tiger nut meal commenced immediately and lasted for two months. At the end of administration, assay of reproductive hormones (FSH, LH and Testosterone) was done. Comprehensive semen analysis was also done including (count, motility & morphology). Results: The study showed that the induction of BPH resulted in a very significant reduction of FSH while the administration of the tiger nut meal did not show any significant effect on FSH (P 0.05). The same trend was also observed on the effect of the tiger nut meal on LH level. For testosterone, it was observed that after the initial decrease as a result of the induction of infertility, 20% tiger nut meal administration significantly increased the testosterone level to 2.10±0.06 ng/ml from 0.30±0.01 ng/ml in the infertility-induced group. The effect of tiger nut meal on semen analyses namely, normal sperm cells and sperm motility showed a significant increase (P<0.05) following the induction of infertility. The effect of the tiger nut meal on sperm morphological toxicities were also examined. Sperm abnormalities like sperm cells with twisted tails were examined. Conclusion: The administration of tiger nut significantly ameliorated the abnormalities and thus, restored the morphology of the sperm cells such that it can enhance fertility.

scholarly journals Effect of Thymus vulgaris leaf extract on cadmium-induced testicular toxicity in rats

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Remigius Ibe Onoja ◽  
Chinwe Uzoma Chukwudi ◽  
Emmanuel Uchechukwu Ugwueze ◽  
Davinson Chuka Anyogu ◽  
Wilson Obidah ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Sperm Count ◽  
Treated Group ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Thymus Vulgaris ◽  
Testicular Toxicity ◽  
Histological Changes ◽  
Ameliorative Effect ◽  
Testicular Injury

Abstract Background Cadmium (Cd) is a known metallohormone which mimics the action of steroid hormones with adverse effect on testicular function. It is highly toxic and a prevalent environmental contaminant with no conventional antidote. This study investigates the possible ameliorative effects of Thymus vulgaris extract on testicular toxicity induced by Cd in male rats. Results The testicular and epididymal weights, serum concentration of follicle stimulating hormone, luteinizing hormone, and testosterone were significantly (p ≤ 0.05) lower in the cadmium-treated group compared to the control. Necrosis of germ cells of the seminiferous tubules was observed in the testicular tissues of the cadmium-treated group. Administration of extract showed mild but non-significant (p ≥ 0.05) protective effect on the cadmium-induced decrease in sex hormones and sperm count as well as oxidative stress and histological changes. Conclusion Thymus vulgaris leaf extract had weak ameliorative effect on cadmium-induced testicular injury in rats but with promising antioxidant activity.

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