Relation of Serum Interleukin-33 Level to Disease Severity in Asthmatic Patients

2019 ◽  
Vol 27 (1) ◽  
pp. 95-98
Author(s):  
Sahar Z. Elazab
Keyword(s):  
Disease Severity ◽  
Interleukin 33 ◽  
Asthmatic Patients

scholarly journals Plasma neutrophil extracellular trap level is modified by disease severity and inhaled corticosteroids in chronic inflammatory lung diseases

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Zsófia Gál ◽  
András Gézsi ◽  
Éva Pállinger ◽  
Tamás Visnovitz ◽  
Adrienne Nagy ◽  
...  
Keyword(s):  
Disease Severity ◽  
Lung Diseases ◽  
Laser Scanning ◽  
Inhaled Corticosteroids ◽  
Laser Scanning Microscopy ◽  
Neutrophil Extracellular Trap ◽  
Confocal Laser ◽  
Trap Level ◽  
Asthmatic Patients ◽  
Extracellular Trap

AbstractA flow cytometry-based method was developed to quantify in vivo circulating neutrophil extracellular trap (NET) levels in plasma and compare them in patients with different chronic inflammatory lung diseases. Seventeen asthmatic and 11 control children, 12 adult controls, 46 asthmatic, 6 COPD and 6 adult patients with asthma-COPD overlap syndrome (ACOS) were recruited in the study. The presence of NETs in unstimulated cell-free plasma was confirmed and visualized by confocal laser-scanning microscopy. No significant differences were found in plasma NET levels between children and adults, children with or without asthma and adults with or without asthma, COPD or ACOS. When asthmatic patients were stratified according to their disease severity the average plasma NET level was significantly higher in asthmatic patients with more serious symptoms (adjusted p = 0.027). Patients with poorer pulmonary functions had higher plasma NET levels which negatively correlated with the FEV1 values (r = −0.39, p = 0.002). Patients who were medicated daily with inhaled corticosteroids (ICS) had significantly lower average plasma NET level than patients who did not or just occasionally used ICS (p = 0.027). If further studies confirm the NET-lowering effect of ICS in the circulation, it can be utilized in diseases where NETosis contributes to the pathogenesis.

Characterization of interleukin-33 and matrix metalloproteinase-28 in serum and their association with disease severity in patients with coronary heart disease

2014 ◽  
Vol 25 (6) ◽  
pp. 498-504 ◽  
Author(s):  
Cong-Lin Liu ◽  
De-Liang Shen ◽  
Kui Zhu ◽  
Jun-Nan Tang ◽  
Xiao-Fang Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Matrix Metalloproteinase ◽  
Disease Severity ◽  
Interleukin 33

scholarly journals Comparison of Interleukin-33 serum levels in asthmatic patients with a control group and relation with the severity of the disease

2017 ◽  
Vol 8 (1) ◽  
pp. 65 ◽  
Author(s):  
SeyedehAzra Shamsdin ◽  
Tooba Momen ◽  
Hamid Ahanchian ◽  
Mohsen Reisi ◽  
Armindokht Shahsanai ◽  
...  
Keyword(s):  
Serum Levels ◽  
Control Group ◽  
Interleukin 33 ◽  
Asthmatic Patients ◽  
Severity Of The Disease

Are leukocytes in asthmatic patients aging faster? A study of telomere length and disease severity

2013 ◽  
Vol 132 (2) ◽  
pp. 480-482.e2 ◽  
Author(s):  
Shigenori Kyoh ◽  
Narayanan Venkatesan ◽  
Audrey H. Poon ◽  
Michiyoshi Nishioka ◽  
Ting-Yu Lin ◽  
...  
Keyword(s):  
Telomere Length ◽  
Disease Severity ◽  
Asthmatic Patients

Characterization of Interleukin-33 and Soluble ST2 in Serum and Their Association with Disease Severity in Patients with Chronic Kidney Disease

2011 ◽  
Vol 32 (3) ◽  
pp. 587-594 ◽  
Author(s):  
Yu-Shi Bao ◽  
Shi-Ping Na ◽  
Ping Zhang ◽  
Xi-Bei Jia ◽  
Rui-Chan Liu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Severity ◽  
Soluble St2 ◽  
Interleukin 33

Leukotriene EM4plasma levels in adult asthmatic patients with variable disease severity

Allergy ◽  
1997 ◽  
Vol 52 (5) ◽  
pp. 589-592 ◽  
Author(s):  
C. Chavis ◽  
T. Vyve ◽  
P. Chanez ◽  
M. Farce ◽  
J. Bousquet ◽  
...  
Keyword(s):  
Disease Severity ◽  
Asthmatic Patients ◽  
Adult Asthmatic

scholarly journals Serum levels of interleukin-33 in alopecia areata: relation to disease severity and chronicity

2021 ◽  
Vol 18 (3) ◽  
pp. 210
Author(s):  
FairouzK Badran ◽  
AmiraA Eid ◽  
YasmineA Issa ◽  
EmanM Abdel Maksoud
Keyword(s):  
Disease Severity ◽  
Alopecia Areata ◽  
Serum Levels ◽  
Interleukin 33

scholarly journals Interleukin-33 contributes to disease severity in Dengue virus infection in mice

Immunology ◽  
2018 ◽  
Vol 155 (4) ◽  
pp. 477-490 ◽  
Author(s):  
Rafael E. Marques ◽  
Anne-Gaëlle Besnard ◽  
Isabelle Maillet ◽  
Caio T. Fagundes ◽  
Danielle G. Souza ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Dengue Virus Infection ◽  
Interleukin 33

Anti-IgE Significantly Changes Circulating Interleukin-25, Vitamin-D and Interleukin-33 Levels in Patients with Allergic Asthma

2019 ◽  
Vol 25 (35) ◽  
pp. 3784-3795 ◽  
Author(s):  
Arzu D. Yalcin ◽  
Rusen Uzun
Keyword(s):  
Significant Relationship ◽  
Eosinophil Cationic Protein ◽  
Length Of Hospital Stay ◽  
Specific Ige ◽  
The Other ◽  
Act Scores ◽  
Asthma Control Test ◽  
Cationic Protein ◽  
Interleukin 33 ◽  
Asthmatic Patients

Background: Multi-center, randomized-controlled trials and observational studies have demonstrated that, in severe asthmatic patients receiving omalizumab treatment, the frequency of exacerbations, the number of urgent adverse events, and the need for oral steroids tend to decrease. Material and Method: This study included a total of 32 patients. The patients were divided into two groups as Group IA (pre-omalizumab) and Group IB (post-omalizumab). Serum IL-25 and IL-33 levels were measured and the number of emergency admissions, length of hospitalization (day), Asthma Control Test (ACT) scores, eosinophil cationic protein (ECP), and fractional exhaled nitric oxide (FeNO) value were analyzed. Results: ACT and FeNO values increased after omalizumab treatment, while IL-33, IL-25 levels decreased after the completion of omalizumab treatment. Furthermore, there was a weak, positive, and significant relationship between the changes in the ECP levels and IL-33 levels (r=0.38, p=0.03). Conclusion: To the best of our knowledge, this is the first study to compare circulating IL-25 and IL-33 levels with specific IgE synthesis in the literature. Multivariate correlation analysis showed that the changes in serum IL-33 levels were significantly correlated with the changes in the mite sIgE levels and length of hospital stay (Fmodel=11.2, p=0.01, r2=0.45). On the other hand, there was no significant relationship between the other variables and changes in the IL-25 levels.

scholarly journals Serum levels of Interleukin-33 and its soluble receptor ST2 in asthmatic patients

2014 ◽  
Vol 63 (2) ◽  
pp. 279-284 ◽  
Author(s):  
Ensaf A. Azazi ◽  
Ashraf E. Elshora ◽  
Enas A. Tantawy ◽  
Marwa A. Elsayd
Keyword(s):  
Serum Levels ◽  
Soluble Receptor ◽  
Interleukin 33 ◽  
Asthmatic Patients
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