scholarly journals Prospective Cohort Study of Lead Exposure and Electrocardiographic Conduction Disturbances in the Department of Veterans Affairs Normative Aging Study

2011 ◽  
Vol 119 (7) ◽  
pp. 940-944 ◽  
Author(s):  
Ki-Do Eum ◽  
Linda H. Nie ◽  
Joel Schwartz ◽  
Pantel S. Vokonas ◽  
David Sparrow ◽  
...  
1998 ◽  
Vol 82 (5) ◽  
pp. 594-599 ◽  
Author(s):  
Yawen Cheng ◽  
Joel Schwartz ◽  
Pantel S Vokonas ◽  
Scott T Weiss ◽  
Antonio Aro ◽  
...  

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2750 ◽  
Author(s):  
Xin Wang ◽  
Douglas Kim ◽  
Katherine L. Tucker ◽  
Marc G. Weisskopf ◽  
David Sparrow ◽  
...  

Bone is a major storage site as well as an endogenous source of lead in the human body. Dietary sodium and potassium intake may play a role in the mobilization of lead from bone to the circulation. We examined whether association between bone lead and urinary lead, a marker of mobilized lead in plasma, was modified by dietary intake of sodium and potassium among 318 men, aged 48–93 years, in the Veterans Affairs (VA) Normative Aging Study. Dietary sodium and potassium were assessed by flame photometry using 24-h urine samples, and a sodium-to-potassium ratio was calculated from the resulting measures. Patella and tibia bone lead concentrations were measured by K-shell-x-ray fluorescence. Urinary lead was measured by inductively coupled plasma mass spectroscopy in 24-h urine samples. Linear regression models were used to regress creatinine clearance-corrected urinary lead on bone lead, testing multiplicative interactions with tertiles of sodium, potassium, and sodium-to-potassium ratio, separately. After adjustment for age, body mass index, smoking, vitamin C intake, calcium, and total energy intake, participants in the highest tertile of sodium-to-potassium ratio showed 28.1% (95% CI: 12.5%, 45.9%) greater urinary lead per doubling increase in patella lead, whereas those in the second and lowest tertiles had 13.8% (95% CI: −1.7%, 31.7%) and 5.5% (95% CI: −8.0%, 21.0%) greater urinary lead, respectively (p-for-interaction = 0.04). No statistically significant effect modification by either sodium or potassium intake alone was observed. These findings suggest that relatively high intake of sodium relative to potassium may play an important role in the mobilization of lead from bone into the circulation.


1994 ◽  
Vol 140 (9) ◽  
pp. 821-829 ◽  
Author(s):  
Marinelle Payton ◽  
Howard Hu ◽  
David Sparrow ◽  
Scott T. Weiss

2009 ◽  
Vol 139 (12) ◽  
pp. 2329-2336 ◽  
Author(s):  
Ondine van de Rest ◽  
Avron Spiro ◽  
Elizabeth Krall-Kaye ◽  
Johanna M. Geleijnse ◽  
Lisette C. P. G. M. de Groot ◽  
...  

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Kelly Bakulski ◽  
Sung Kyun Park ◽  
Howard Hu ◽  
Huiling Nie ◽  
David Sparrow ◽  
...  

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