Natural and cause-specific mortality and long-term exposure to particle components in a pooled cohort of 323,782 participants in Europe: the ELAPSE project

ABSTRACT Background Controversy has emerged about the benefits compared with harms of dairy fat, including concerns over long-term effects. Previous observational studies have assessed self-reported estimates of consumption or a single biomarker measure at baseline, which may lead to suboptimal estimation of true risk. Objective The aim of this study was to investigate prospective associations of serial measures of plasma phospholipid fatty acids pentadecanoic (15:0), heptadecanoic (17:0), and trans-palmitoleic (trans-16:1n–7) acids with total mortality, cause-specific mortality, and cardiovascular disease (CVD) risk among older adults. Design Among 2907 US adults aged ≥65 y and free of CVD at baseline, circulating fatty acid concentrations were measured serially at baseline, 6 y, and 13 y. Deaths and CVD events were assessed and adjudicated centrally. Prospective associations were assessed by multivariate-adjusted Cox models incorporating time-dependent exposures and covariates. Results During 22 y of follow-up, 2428 deaths occurred, including 833 from CVD, 1595 from non-CVD causes, and 1301 incident CVD events. In multivariable models, circulating pentadecanoic, heptadecanoic, and trans-palmitoleic acids were not significantly associated with total mortality, with extreme-quintile HRs of 1.05 for pentadecanoic (95% CI: 0.91, 1.22), 1.07 for heptadecanoic (95% CI: 0.93, 1.23), and 1.05 for trans-palmitoleic (95% CI: 0.91, 1.20) acids. Circulating heptadecanoic acid was associated with lower CVD mortality (extreme-quintile HR: 0.77; 95% CI: 0.61, 0.98), especially stroke mortality, with a 42% lower risk when comparing extreme quintiles of heptadecanoic acid concentrations (HR: 0.58; 95% CI: 0.35, 0.97). In contrast, heptadecanoic acid was associated with a higher risk of non-CVD mortality (HR: 1.27; 95% CI: 1.07, 1.52), which was not clearly related to any single subtype of non-CVD death. No significant associations of pentadecanoic, heptadecanoic, or trans-palmitoleic acids were seen for total incident CVD, coronary heart disease, or stroke. Conclusions Long-term exposure to circulating phospholipid pentadecanoic, heptadecanoic, or trans-palmitoleic acids was not significantly associated with total mortality or incident CVD among older adults. High circulating heptadecanoic acid was inversely associated with CVD and stroke mortality and potentially associated with higher risk of non-CVD death.

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Association of Coronary Artery Calcium With Long-term, Cause-Specific Mortality Among Young Adults

JAMA Network Open ◽

10.1001/jamanetworkopen.2019.7440 ◽

2019 ◽

Vol 2 (7) ◽

pp. e197440 ◽

Cited By ~ 15

Author(s):

Michael D. Miedema ◽

Zeina A. Dardari ◽

Khurram Nasir ◽

Ron Blankstein ◽

Thomas Knickelbine ◽

...

Keyword(s):

Young Adults ◽

Coronary Artery ◽

Coronary Artery Calcium ◽

Specific Mortality

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Long-term seasonal and spatial patterns in mortality and survival of Calanus finmarchicus across the Atlantic Zone Monitoring Programme region, Northwest Atlantic

ICES Journal of Marine Science ◽

10.1093/icesjms/fsp167 ◽

2009 ◽

Vol 66 (9) ◽

pp. 1942-1958 ◽

Cited By ~ 32

Author(s):

Stéphane Plourde ◽

Pierre Pepin ◽

Erica J. H. Head

Keyword(s):

Population Growth ◽

Spatial Patterns ◽

Phytoplankton Biomass ◽

Mortality Rates ◽

Monitoring Programme ◽

Calanus Finmarchicus ◽

Northwest Atlantic ◽

Specific Mortality ◽

Main Factor

Abstract Plourde, S., Pepin, P., and Head, E. J. H. 2009. Long-term seasonal and spatial patterns in mortality and survival of Calanus finmarchicus across the Atlantic Zone Monitoring Programme region, Northwest Atlantic. – ICES Journal of Marine Science, 66: 1942–1958. The vertical life table method was used to estimate stage-specific daily mortality rates and survival from 1999 to 2006 for Calanus finmarchicus sampled in the Canadian Atlantic Zone Monitoring Programme, which covers the Newfoundland–Labrador Shelf (NLS), Gulf of St Lawrence (GSL), and Scotian Shelf (SS). Stage-specific mortality rates and survival showed significant regional and seasonal differences, with the largest signal associated with variations in temperature. Density-dependent mortality, associated with the abundance of C6 females, was the main factor influencing mortality in the egg–C1 transition during the period of population growth in spring on the SS, and in summer in the GSL and on the NLS. In autumn, mortality in egg–C1 was positively related to temperature and negatively related to phytoplankton biomass, with particularly high mortality rates on the SS. The integration of our results into stage-specific recruitment rates from egg to C5 revealed that C. finmarchicus populations experience their greatest loss (mortality) during the egg–C1 transition. Loss during development to C1 was greater in the GSL than in the other regions during the period of population growth, resulting in lower recruitment success in the GSL. In autumn, C. finmarchicus showed low stage-specific daily recruitment rates on the SS at high temperatures, and low phytoplankton biomass compared with those in the GSL and on the NLS. Our findings reinforce the necessity of describing regional and seasonal patterns in mortality and survival to understand factors controlling the population dynamics of C. finmarchicus.

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Long-Term Exposure to Silica Dust and Risk of Total and Cause-Specific Mortality in Chinese Workers: A Cohort Study

PLoS Medicine ◽

10.1371/journal.pmed.1001206 ◽

2012 ◽

Vol 9 (4) ◽

pp. e1001206 ◽

Cited By ~ 110

Author(s):

Weihong Chen ◽

Yuewei Liu ◽

Haijiao Wang ◽

Eva Hnizdo ◽

Yi Sun ◽

...

Keyword(s):

Cohort Study ◽

Silica Dust ◽

Specific Mortality ◽

Chinese Workers

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Subsequent Migration of Immigrants Within Australia, 1981–2016

Population Research and Policy Review ◽

10.1007/s11113-018-9482-4 ◽

2018 ◽

Vol 37 (6) ◽

pp. 1053-1077 ◽

Cited By ~ 10

Author(s):

James Raymer ◽

Bernard Baffour

Keyword(s):

Internal Migration ◽

Total Population ◽

Census Data ◽

Mortality Data ◽

Host Countries ◽

Immigrant Populations ◽

The United Kingdom ◽

Specific Mortality ◽

Relative Attractiveness

Abstract Australia is a major immigration country and immigrants currently represent around 28% of the total population. The aim of this research is to understand the long-term consequences of this immigration and, particularly, how migrants respond to opportunities within the country after arriving through the process of subsequent (internal) migration. The focus is on major immigrant groups in Australia, including persons born in the United Kingdom, New Zealand, China and India, and how their patterns differ from persons born in Australia. To conduct this analysis, we have gathered data for a 35-year period based on quinquennial census data. We also obtained birthplace-specific mortality data for constructing multiregional life tables for the immigrant populations. Subsequent migration is important for understanding population redistribution, and the relative attractiveness of destinations within host countries. Our results highlight the importance of subsequent migration and the diversity of migration behaviours amongst different immigrant groups in the context of overall declines in internal migration since 1981.

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Abstract 3012: Long-term aspirin use and total and cancer-specific mortality

10.1158/1538-7445.am2017-3012 ◽

2017 ◽

Author(s):

Yin Cao ◽

Meir Stampfer ◽

Walter Willett ◽

Donna Spiegelman ◽

JoAnn Manson ◽

...

Keyword(s):

Specific Mortality ◽

Cancer Specific Mortality

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Patient Age and Survival After Surgery for Esophageal Cancer

Annals of Surgical Oncology ◽

10.1245/s10434-020-08653-w ◽

2020 ◽

Vol 28 (1) ◽

pp. 159-166 ◽

Cited By ~ 1

Author(s):

Jesper Lagergren ◽

Matteo Bottai ◽

Giola Santoni

Keyword(s):

Esophageal Cancer ◽

Short Term ◽

Term Survival ◽

Long Term Survival ◽

Flexible Parametric Model ◽

All Cause Mortality ◽

Specific Mortality ◽

Disease Specific Mortality ◽

Disease Specific

Abstract Background Esophagectomy for esophageal cancer is associated with a substantial risk of life-threatening complications and a limited long-term survival. This study aimed to clarify the controversial questions of how age influences short-term and long-term survival. Methods This population-based cohort study included almost all patients who underwent curatively intended esophagectomy for esophageal cancer in Sweden in 1987–2010, with follow-up through 2016. The exposure was age, analyzed both as a continuous and categorical variable. The probability of mortality was computed using a novel flexible parametric model approach. The reported probabilities are proper measures of the risk of dying, and the related odds ratios (OR) are therefore more suitable measures of association than hazard ratios. The outcomes were 90-day all-cause mortality, 5-year all-cause mortality, and 5-year disease-specific mortality. A novel flexible parametric model was used to derive the instantaneous probability of dying and the related OR along with 95% confidence intervals (CIs), adjusted for sex, education, comorbidity, tumor histology, pathological tumor stage, and resection margin status. Results Among 1737 included patients, the median age was 65.6 years. When analyzed as a continuous variable, older age was associated with slightly higher odds of 90-day all-cause mortality (OR 1.05, 95% CI 1.02–1.07), 5-year all-cause mortality (OR 1.02, 95% CI 1.01–1.03), and 5-year disease-specific mortality (OR 1.01, 95% CI 1.01–1.02). Compared with patients aged < 70 years, those aged 70–74 years had no increased risk of any mortality outcome, while patients aged ≥ 75 years had higher odds of 90-day mortality (OR 2.85, 95% CI 1.68–4.84), 5-year all-cause mortality (OR 1.56, 95% CI 1.27–1.92), and 5-year disease-specific mortality (OR 1.38, 95% CI 1.09–1.76). Conclusions Patient age 75 years or older at esophagectomy for esophageal cancer appears to be an independent risk factor for higher short-term mortality and lower long-term survival.

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