scholarly journals Neurogenesis in Neurotoxin-induced Animal Models for Parkinson's Disease-A Review of the Current Status

2009 ◽  
Vol 22 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Xi Jun He ◽  
Hiroyuki Nakayama
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Current Status

scholarly journals Effectiveness and mechanisms of adipose-derived stem cell therapy in animal models of Parkinson’s disease: a systematic review and meta-analysis

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Keya Li ◽  
Xinyue Li ◽  
Guiying Shi ◽  
Xuepei Lei ◽  
Yiying Huang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Therapeutic Option ◽  
Meta Analysis ◽  
Future Application ◽  
Neuroprotective Effects ◽  
Standard Mean Difference ◽  
Study Characteristics

AbstractAnimal models provide an opportunity to assess the optimal treatment way and the underlying mechanisms of direct clinical application of adipose-derived stem cells (ADSCs). Previous studies have evaluated the effects of primitive and induced ADSCs in animal models of Parkinson’s disease (PD). Here, eight databases were systematically searched for studies on the effects and in vivo changes caused by ADSC intervention. Quality assessment was conducted using a 10-item risk of bias tool. For the subsequent meta-analysis, study characteristics were extracted and effect sizes were computed. Ten out of 2324 published articles (n = 169 animals) were selected for further meta-analysis. After ADSC therapy, the rotation behavior (10 experiments, n = 156 animals) and rotarod performance (3 experiments, n = 54 animals) were improved (P < 0.000 01 and P = 0.000 3, respectively). The rotation behavior test reflected functional recovery, which may be due to the neurogenesis from neuronally differentiated ADSCs, resulting in a higher pooled effect size of standard mean difference (SMD) (− 2.59; 95% CI, − 3.57 to − 1.61) when compared to that of primitive cells (− 2.18; 95% CI, − 3.29 to − 1.07). Stratified analyses by different time intervals indicated that ADSC intervention exhibited a long-term effect. Following the transplantation of ADSCs, tyrosine hydroxylase-positive neurons recovered in the lesion area with pooled SMD of 13.36 [6.85, 19.86]. Transplantation of ADSCs is a therapeutic option that shows long-lasting effects in animal models of PD. The potential mechanisms of ADSCs involve neurogenesis and neuroprotective effects. The standardized induction of neural form of transplanted ADSCs can lead to a future application in clinical practice.

Antidyskinetic effect of A2Aand 5HT1A/1Breceptor ligands in two animal models of Parkinson's disease

2016 ◽  
Vol 31 (4) ◽  
pp. 501-511 ◽  
Author(s):  
Annalisa Pinna ◽  
Wai Kin D. Ko ◽  
Giulia Costa ◽  
Elisabetta Tronci ◽  
Camino Fidalgo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models

scholarly journals Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Kyota Fujita ◽  
Yusaku Nakabeppu ◽  
Mami Noda
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Animal Studies ◽  
Clinical Symptoms ◽  
Therapeutic Effects ◽  
Therapeutic Approaches ◽  
Cellular Apoptosis ◽  
6 Hydroxydopamine

Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons. Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen. Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models. Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD.

scholarly journals Tango Therapy: Current Status and the Next Perspective

2018 ◽  
Vol 3 (8) ◽  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dance Therapy ◽  
Well Being ◽  
Medical Application ◽  
Whole Body ◽  
Current Status ◽  
Argentine Tango ◽  
Systemic Analysis ◽  
Health And Well Being

Dance is basically a complex physical activity which either casually or formally organized in which people take part for fitness, health and well-being, social relationships or competition and a worldwide human activity that involves complex whole body movements through space synchronized to music. Dance-related reviews of evidence have examined the effectiveness of dance therapy on psychological and physical health and well-being outcomes in patients with cancer, for schizophrenia, and on depression. Dance therapy was officially described firstly in 1948. The medical application of dance therapy was well reviewed in neurologic conditions. Dance has been used extensively for the treatment of gait and balance dysfunction in individuals with Parkinson’s disease. Especially, Argentine tango is the most frequently employed dance form in the treatment of Parkinson’s disease. Tango therapy may hold promise as an intervention to improve gait, balance, and mobility in a variety of neurological conditions. Tango therapy was approached from dance therapy to the current status of medical application. A more systemic analysis of tango movement for proper and effective therapeutic application of tango is necessary for medical purposes.

scholarly journals Etiologies of insomnia in Parkinson's disease – Lessons from human studies and animal models

2022 ◽  
pp. 113976
Author(s):  
Aviv D. Mizrahi-Kliger ◽  
Lucia K. Feldmann ◽  
Andrea A. Kuhn ◽  
Hagai Bergman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Human Studies
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