scholarly journals REvisiting Lipids in REtinal Diseases: A Focused Review on Age-related Macular Degeneration and Diabetic Retinopathy

2020 ◽  
Vol 9 (3) ◽  
pp. 406
Author(s):  
Su Jin Park ◽  
Dong Ho Park
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Retinal Diseases ◽  
Age Related

scholarly journals Multifocal intraocular lenses and retinal diseases

2020 ◽  
Vol 258 (4) ◽  
pp. 805-813 ◽  
Author(s):  
Andrzej Grzybowski ◽  
Piotr Kanclerz ◽  
Raimo Tuuminen
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Degeneration ◽  
Contrast Sensitivity ◽  
Intraocular Lenses ◽  
Age Related Macular Degeneration ◽  
Visual Field Defects ◽  
Retinal Diseases ◽  
Epiretinal Membranes ◽  
Multifocal Intraocular Lenses ◽  
Age Related

Abstract Purpose Multifocal intraocular lenses (MIOLs) are often discouraged in patients with or at risk of retinal disorders (including diabetic retinopathy, age-related macular degeneration, and epiretinal membranes), as MIOLs are believed to reduce contrast sensitivity (CS). Concerns with MIOLs have also been raised in individuals with visual field defects, fixation instability or eccentric preferred retinal locations. The aim of this study is to review the influence of MIOL on quality of vision in patients with retinal diseases. Methods We reviewed the PubMed and Web of Science databases to identify relevant studies using the following keywords: multifocal intraocular lens, cataract surgery, cataract extraction, lens exchange, diabetic retinopathy, age-related macular degeneration, and contrast sensitivity. Results Studies evaluating CS in MIOLs present conflicting results: MIOLs either did not influence CS or resulted in worse performance under low-illuminance conditions and higher spatial frequencies when compared to monofocal IOLs. Nevertheless, MIOLs preserved CS levels within the age-matched normal range. Two studies reported that patients with concurrent retinal diseases receiving a MIOL, both unilaterally and bilaterally, reported a significant improvement in visual-related outcomes. Individuals with a monofocal IOL in one eye and a MIOL in the fellow eye reported greater subjective satisfaction with the MIOL. Conclusion We were unable to find evidence suggesting that patients with retinal diseases should be advised against MIOLs. Nevertheless, more research is needed to address the aforementioned concerns and to optimize the use of MIOLs in eyes with retinal disease.

scholarly journals Update of application of olfactory ensheathing cells and stem cells/exosomes in the treatment of retinal disorders

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Yang Yu ◽  
Licheng Li ◽  
Shu Lin ◽  
Jianmin Hu
Keyword(s):  
Stem Cells ◽  
Diabetic Retinopathy ◽  
Retinitis Pigmentosa ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Olfactory Ensheathing Cells ◽  
Retinal Diseases ◽  
Age Related ◽  
Retinal Disorders ◽  
Ensheathing Cells

AbstractAge-related macular degeneration, diabetic retinopathy, retinitis pigmentosa and other retinal disorders are the main causes of visual impairment worldwide. In the past, these retinal diseases, especially dry age-related macular degeneration, proliferative diabetic retinopathy and retinitis pigmentosa, were treated with traditional surgery and drugs. However, the effect was moderate. In recent years, researchers have used embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, olfactory ensheathing cells and other stem cells to conduct experiments and found that stem cells can inhibit inflammation, regulate immune response, secrete neurotrophic factors, and differentiate into retinal cells to replace and promote restoration of the damaged parts. These stem cells have the potential to treat retinal diseases. Whether it is in animal experiments or clinical trials, the increase in the number of retinal cells, maintenance of function and improvement of visual function all reflect the advanced of stem cells to treat retinal diseases, but its risk preserves the donor’s hidden pathogenic genes, immune rejection and tumorigenicity. With the development of exosomes study, researchers have discovered that exosomes come from a wide range of sources and can be secreted by almost all types of cells. Using exosomes with stem cell to treat retinal diseases is more effective than using stem cells alone. This review article summarizes the recent advances in the application of olfactory ensheathing cells and stem cells/exosomes in the treatment of retinal disorders.

scholarly journals A Research on Retinal Diseases Predictionin Image Processing

2020 ◽  
Vol 9 (3S) ◽  
pp. 384-388
Keyword(s):  
Image Processing ◽  
Diabetic Retinopathy ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Medical Applications ◽  
Retinal Diseases ◽  
Clear View ◽  
Age Related ◽  
Infected Area

In this paper, a detail survey on retinal diseases identification using image processing is discussed. The retinal diseases are glaucoma, cataract, hypersensitive retinopathy, diabetic retinopathy, age related macular degeneration. The image processing provides greater innovation in medical applications. Image processing gives clear view to determine the infected area. Different algorithms and different procedure were followed here. The survey of detection in retinal diseases includes algorithms are elaborated and compared which are useful for researchers in image processing .This help the researcher get a detailed view of image processing in retinal diseases identification.

scholarly journals Review of Subthreshold Diode Micropulse Laser Treatment for Retinal Diseases

2018 ◽  
Vol 1 (1) ◽  
pp. 62-70
Author(s):  
Juhn AT ◽  
Shyu AP ◽  
Benjamin J ◽  
Zhang Y
Keyword(s):  
Diabetic Retinopathy ◽  
Treatment Modality ◽  
Branch Retinal Vein Occlusion ◽  
Age Related Macular Degeneration ◽  
Clinical Settings ◽  
Retinal Diseases ◽  
Micropulse Laser ◽  
Vein Occlusion ◽  
Age Related ◽  
New Treatment

Subthreshold Diode Micropulse (SDM) laser is a relatively new treatment modality that confers very little to no anatomical risk to the retina. However, its efficacy is still being studied, and the scenario where SDM is most useful is still being elucidated. This paper reviews articles from 1997 to 2017 and reviews the settings, results, and outcomes of SDM in various clinical settings including diabetic macular edema, branch retinal vein occlusion, central serous Chorioretinopathy, proliferative diabetic retinopathy, and age-related macular degeneration.

scholarly journals The prevalence of undiagnosed age-related sight threatening diseases in self-proclaimed healthy individuals

2019 ◽  
Author(s):  
Sophie Lemmens ◽  
João Barbosa Breda ◽  
Karel Van Keer ◽  
Tine Jacobs ◽  
Ruben Van Landeghem ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Degeneration ◽  
Significant Proportion ◽  
Clinical Findings ◽  
Age Related Macular Degeneration ◽  
Ophthalmological Examination ◽  
Healthy Elderly ◽  
Age Related ◽  
Medical Questionnaire

Abstract Background Age-related conditions such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DRP) and cataract have become the major cause of visual impairment and blindness in high-income countries and carry a major socio-economic burden. The aim of the current study is to investigate the prevalence of age-related eye diseases such as glaucoma, age-related macular degeneration, diabetic retinopathy and cataract in a cohort of self-proclaimed healthy elderly, and thus get a rough estimation of the prevalence of undiagnosed age-related eye conditions in the Belgian population.Methods Individuals aged 55 and older without ophthalmological complaints were asked to fill in a general medical questionnaire and underwent an ophthalmological examination, which included a biomicroscopic examination, intraocular pressure measurement, axial length measurement, and acquisition of fundus pictures and Optical Coherence Tomography scans. Information regarding follow-up was collected in the subset of participants who received the advice of referral to an ophthalmologist or the advice to have more frequent follow-up visits, based on the ophthalmological changes detected in their evaluation.Results The cohort included 102 people and comprised 46% men (median age 70 years, range 57-85 years). Referral for additional examinations based on clinical findings, was made in 26 participants (25%). The advice to have more regular follow-up ophthalmologist visits was given to nine additional participants (9%). No significant correlations between baseline characteristics, including eye care consumption, and the need for referral could be identified. Follow-up information was available for 25 out of 26 referred volunteers (96%). Out of these, four (16%) underwent a therapeutical intervention based on study referral, up until 18 months after study participation. All four interventions took place in the age group 65 - 74 years.Conclusions This study shows that even in an elderly population with self-proclaimed healthy eyes and good general health, a significant proportion of subjects showed ocular findings that need regular follow up and/or intervention. Moreover, the frequency of prior ophthalmological examinations does not seem to be relevant to this proportion, meaning that everyone above 55 years old needs a routine ophthalmological evaluation.

scholarly journals Improving Efficiency in Separating Blood Vessels from Retinal Images with Deep Learning Techniques

2019 ◽  
Vol 8 (2S11) ◽  
pp. 3637-3640
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Macular Degeneration ◽  
Blood Vessels ◽  
Age Related Macular Degeneration ◽  
Retinal Images ◽  
Retinal Vessels ◽  
Age Related ◽  
Learning Techniques ◽  
Retinal Pathologies

Retinal vessels ID means to isolate the distinctive retinal configuration issues, either wide or restricted from fundus picture foundation, for example, optic circle, macula, and unusual sores. Retinal vessels recognizable proof investigations are drawing in increasingly more consideration today because of pivotal data contained in structure which is helpful for the identification and analysis of an assortment of retinal pathologies included yet not restricted to: Diabetic Retinopathy (DR), glaucoma, hypertension, and Age-related Macular Degeneration (AMD). With the advancement of right around two decades, the inventive methodologies applying PC supported systems for portioning retinal vessels winding up increasingly significant and coming nearer. Various kinds of retinal vessels segmentation strategies discussed by using Deep Learning methods. At that point, the pre-processing activities and the best in class strategies for retinal vessels distinguishing proof are presented.

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