Enhancing Hip Fracture Risk Prediction in Older Adults by Accounting for the Femur’s Shape and Bone Mineral Density Distribution

OrthoMedia ◽  
2022 ◽  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Density Distribution ◽  
Risk Prediction ◽  
Bone Mineral ◽  
Mineral Density ◽  
Fracture Risk Prediction ◽  
Bone Mineral Density Distribution

The impact of degenerative conditions in the spine on bone mineral density and fracture risk prediction

1996 ◽  
Vol 6 (1) ◽  
pp. 43-49 ◽  
Author(s):  
P. Recke1 ◽  
M. A. Hansen ◽  
K. Overgaard ◽  
C. Christiansen
Keyword(s):  
Bone Mineral Density ◽  
Fracture Risk ◽  
Risk Prediction ◽  
Bone Mineral ◽  
Mineral Density ◽  
The Impact ◽  
Fracture Risk Prediction

scholarly journals The Effect of Quantitative Computed Tomography Acquisition Protocols on Bone Mineral Density Estimation

2015 ◽  
Vol 137 (11) ◽  
Author(s):  
Hugo Giambini ◽  
Dan Dragomir-Daescu ◽  
Paul M. Huddleston ◽  
Jon J. Camp ◽  
Kai-Nan An ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Fracture Risk ◽  
Risk Prediction ◽  
Material Property ◽  
Bone Mineral ◽  
Quantitative Computed Tomography ◽  
Patient Specific ◽  
Mineral Density ◽  
Fracture Risk Prediction

Osteoporosis is characterized by bony material loss and decreased bone strength leading to a significant increase in fracture risk. Patient-specific quantitative computed tomography (QCT) finite element (FE) models may be used to predict fracture under physiological loading. Material properties for the FE models used to predict fracture are obtained by converting grayscale values from the CT into volumetric bone mineral density (vBMD) using calibration phantoms. If there are any variations arising from the CT acquisition protocol, vBMD estimation and material property assignment could be affected, thus, affecting fracture risk prediction. We hypothesized that material property assignments may be dependent on scanning and postprocessing settings including voltage, current, and reconstruction kernel, thus potentially having an effect in fracture risk prediction. A rabbit femur and a standard calibration phantom were imaged by QCT using different protocols. Cortical and cancellous regions were segmented, their average Hounsfield unit (HU) values obtained and converted to vBMD. Estimated vBMD for the cortical and cancellous regions were affected by voltage and kernel but not by current. Our study demonstrated that there exists a significant variation in the estimated vBMD values obtained with different scanning acquisitions. In addition, the large noise differences observed utilizing different scanning parameters could have an important negative effect on small subregions containing fewer voxels.

Fracture Risk Prediction Using Phalangeal Bone Mineral Density or FRAX®?—A Danish Cohort Study on Men and Women

2014 ◽  
Vol 17 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Teresa Friis-Holmberg ◽  
Katrine Hass Rubin ◽  
Kim Brixen ◽  
Janne Schurmann Tolstrup ◽  
Mickael Bech
Keyword(s):  
Bone Mineral Density ◽  
Cohort Study ◽  
Fracture Risk ◽  
Risk Prediction ◽  
Bone Mineral ◽  
Mineral Density ◽  
Men And Women ◽  
Danish Cohort ◽  
Phalangeal Bone ◽  
Fracture Risk Prediction

Absolute Fracture-Risk Prediction by a Combination of Calcaneal Quantitative Ultrasound and Bone Mineral Density

2011 ◽  
Vol 90 (2) ◽  
pp. 128-136 ◽  
Author(s):  
Mei Y. Chan ◽  
Nguyen D. Nguyen ◽  
Jacqueline R. Center ◽  
John A. Eisman ◽  
Tuan V. Nguyen
Keyword(s):  
Bone Mineral Density ◽  
Fracture Risk ◽  
Risk Prediction ◽  
Bone Mineral ◽  
Quantitative Ultrasound ◽  
Mineral Density ◽  
Calcaneal Quantitative Ultrasound ◽  
Fracture Risk Prediction

scholarly journals Weight loss since early adulthood, later life risk of fracture hospitalizations, and bone mineral density: a prospective cohort study of 0.5 million Chinese adults

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Zewei Shen ◽  
◽  
Canqing Yu ◽  
Yu Guo ◽  
Zheng Bian ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Early Adulthood ◽  
Broadband Ultrasound Attenuation ◽  
Later Life ◽  
Mineral Density

Abstract Summary In a Chinese population from both urban and rural areas, weight loss of ≥ 5 kg from early adulthood to midlife was associated with a higher risk of hip fracture and lower BMD in later life. Introduction This study investigates the association of the long-term weight loss from young adulthood through the middle ages with the subsequent 10-year risk of hospitalized fracture and calcaneus bone mineral density (BMD). Methods China Kadoorie Biobank (CKB) was established during 2004–2008 in ten areas across China. Weight at age 25 years was self-reported at baseline, and weight at baseline and resurvey was measured by the calibrated equipment. Outcomes were hospitalized fracture during follow-up and calcaneus BMD measured at resurvey. Analysis for fracture risk included 411,812 participants who were free of fracture in the last 5 years before baseline, cancer, or stroke at any time before baseline. Analysis for BMD included 21,453 participants who participated in the resurvey of 2013–2014 with the same exclusion criteria as above. Results The mean age was 50.8 at baseline and 58.4 at resurvey. Median weight change from age 25 to baseline was 4.4 kg, with 20.7% losing weight and 58.5% gaining weight. During a median follow-up of 10.1 years, we documented 13,065 cases of first diagnosed fracture hospitalizations, including 1222 hip fracture. Compared with participants whose weight was stable (± 2.4 kg), the adjusted hazard ratios (95% CIs) for those with weight loss of ≥ 5.0 kg from age 25 to baseline was 1.39 (1.17 to 1.66) for hip fracture. Weight loss was not associated with fracture risk at other sites. Those with weight loss from age 25 to resurvey had the lowest BMD measures, with β (95% CIs) of − 4.52 (− 5.08 to − 3.96) for broadband ultrasound attenuation (BUA), − 4.83 (− 6.98, − 2.67) for speed of sound (SOS), and − 4.36 (− 5.22, − 3.49) for stiffness index (SI). Conclusions Weight loss from early adulthood to midlife was associated with a higher risk of hip fracture and lower BMD in later life.

scholarly journals Late stages of mineralization and their signature on the bone mineral density distribution

2018 ◽  
Vol 59 (sup1) ◽  
pp. 74-80 ◽  
Author(s):  
Pascal R. Buenzli ◽  
Chloé Lerebours ◽  
Andreas Roschger ◽  
Paul Roschger ◽  
Richard Weinkamer
Keyword(s):  
Bone Mineral Density ◽  
Density Distribution ◽  
Bone Mineral ◽  
Mineral Density ◽  
Late Stages ◽  
Bone Mineral Density Distribution
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