scholarly journals A giant testicular mixed germ cell tumour

2016 ◽  
Vol 98 (8) ◽  
pp. e171-e172 ◽  
Author(s):  
A Reekhaye ◽  
A Harris ◽  
S Nagarajan ◽  
D Chadwick
Keyword(s):  
Computed Tomography ◽  
United Kingdom ◽  
Germ Cell ◽  
Germ Cell Tumour ◽  
Testicular Tumour ◽  
Medical Attention ◽  
The United Kingdom ◽  
Scrotal Swelling ◽  
Germ Cell Testicular Tumour ◽  
Active Disease

We present a case that we believe to be the largest mixed germ cell testicular tumour reported in the United Kingdom. A 23-year-old male was admitted to our urology department with a large scrotal swelling. The patient was found to have a giant left testicular tumour and a solitary lung metastasis at presentation. He underwent an emergency radical orchidectomy and subsequently received four cycles of bleomycin, etoposide and cisplatin chemotherapy. Four months after starting treatment, the tumour markers had normalised and a repeat staging computed tomography showed no active disease. The tumour reached that size because of the patient’s failure to seek medical attention due to fear and embarrassment.

scholarly journals Availability of computed tomography of the brain in the United Kingdom.

BMJ ◽  
1989 ◽  
Vol 298 (6682) ◽  
pp. 1219-1220 ◽  
Author(s):  
R. L. Hewer ◽  
V. A. Wood
Keyword(s):  
Computed Tomography ◽  
United Kingdom ◽  
The United Kingdom ◽  
The Brain

scholarly journals Results of the United Kingdom children's cancer study group's malignant germ cell tumor studies

Cancer ◽  
1990 ◽  
Vol 63 (9) ◽  
pp. 1657-1667 ◽  
Author(s):  
Jillian R. Mann ◽  
Dorothy Pearson ◽  
Ann Barrett ◽  
Faro Raafat ◽  
Janet M. Barnes ◽  
...  
Keyword(s):  
United Kingdom ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Cancer Study ◽  
The United Kingdom ◽  
Tumor Studies ◽  
Malignant Germ Cell Tumor

Metachronous testicular tumour recurrence in extra-gonadal germ cell tumour: A case report and review of the literature

2020 ◽  
pp. 205141581989276
Author(s):  
Benjamin Storey ◽  
Avi Raman ◽  
Alexander Grant
Keyword(s):  
Germ Cell ◽  
Residual Disease ◽  
Abdominal Mass ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Tissue Type ◽  
Testicular Tumour ◽  
Retroperitoneal Lymph Node Dissection ◽  
Level Of Evidence ◽  
Platinum Based Chemotherapy

A 24-year-old male presented in 2014 with left sided abdominal pain and a palpable abdominal mass. After appropriate investigation a diagnosis of an extra-gonadal germ cell tumour was made and he was treated with platinum based chemotherapy. He then underwent retroperitoneal lymph node dissection due to residual disease identified on imaging with no specific tissue type identified on the histological sample. In early 2019 he presented to his General Practitioner with a left sided testicular lump and was diagnosed with non-seminomatous germ cell tumour of the testis, an uncommon condition; metachronous testicular tumour. Level of Evidence: 5

Burned-out testicular germ cell tumour presenting as acute inferior vena cava syndrome

2020 ◽  
Vol 13 (11) ◽  
pp. e237481
Author(s):  
Peter de Souza ◽  
Chun Wah So ◽  
Deepak Batura ◽  
Wade Gayed ◽  
Eirini Vrentzou
Keyword(s):  
Inferior Vena Cava ◽  
Germ Cell ◽  
Inferior Vena ◽  
Germ Cell Tumour ◽  
Vena Cava ◽  
Testicular Tumour ◽  
Residual Tumour ◽  
Testicular Germ Cell Tumour ◽  
Testicular Germ Cell ◽  
Tissue Mass

Germ cell tumours (GCT) are the most common testicular neoplasms, seen mainly in young adults. Rarely they can affect extragonadal tissues, either as primary tumours or as metastases, most commonly to retroperitoneal lymph nodes. A ‘burned-out’ testicular tumour is a metastatic GCT with a relatively occult primary testicular tumour, which has histologically spontaneously regressed. We report a case of a 26-year-old man who presented with an acute history of lower back pain and leg swelling. CT demonstrated a large retroperitoneal soft tissue mass causing right-sided hydronephrosis with inferior vena cava and iliofemoral vein thrombosis. Although clinical examination of the testis was normal, ultrasound imaging of the scrotum identified a burned-out testicular primary. Orchiectomy confirmed the diagnosis and the patient responded well to chemotherapy, with no viable residual tumour on follow-up imaging. However, despite nephrostomy insertion, a dimercaptosuccinic acid (DMSA) scan demonstrated loss of function of the right kidney after treatment.

Seminoma and sarcoid: A confusing collision.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 339-339
Author(s):  
Claire Brady ◽  
Richard Martin Bambury ◽  
MinYuen Teo ◽  
Alamani El-Gammal ◽  
Julie McCarthy ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Cancer Patients ◽  
Oral Prednisone ◽  
Germ Cell Tumour ◽  
Mediastinal Lymphadenopathy ◽  
High Dose ◽  
Cell Transplant ◽  
Mediastinal Adenopathy ◽  
Scrotal Swelling

339 Background: In patients with active or prior malignancy, the presence of mediastinal lymphadenopathy is often assumed to indicate metastases. However, sarcoidosis can imitate malignancy on CT and PET imaging. The incidence of sarcoidosis or “sarcoid-like reaction” in cancer patients (especially testicular germ cell tumor patients) appears to be higher than in the general population. Methods: We report a series of 4 testicular cancer patients with mediastinal adenopathy mimicking metastatic disease. Subsequent investigations and follow-up revealed sarcoid-like reaction without active malignancy. Results: A 25 year old man presented with a neck swelling and was found to have left cervical adenopathy, mediastinal adenopathy and a right testicular mass. Biopsy of the cervical nodes revealed a mixed seminoma and non-seminomatous germ cell tumour. After 4 cycles of chemotherapy PET/CT revealed persistent hypermetabolic mediastinal adenopathy. Transbronchial needle aspirate (TBNA) revealed non-caseating granulomas (NCGs). After right orchiectomy and retroperitoneal lymph node dissection he remains in complete remission. A 26 year old man presented with scrotal swelling and investigations revealed bilateral testicular seminoma. CT revealed mediastinal adenopathy. TBNA revealed NCGs and he remains disease free after orchiectomy. A 42 year old man presented with right sided scrotal swelling. CT revealed mediastinal adenopathy. TBNA revealed NCGs. He was treated successfully with orchiectomy and chemotherapy for stage 1 seminoma. A 20 yr old man had mediastinal adenopathy on a surveillance CT 5 years after high dose chemotherapy and stem cell transplant for platinum-refractory seminoma. TBNA revealed NCGs and the adenopathy resolved with oral prednisone therapy. Conclusions: Sarcoid-like reaction in cancer patients may be due to an immunologic hypersensitivity to tumor-associated antigens. Although the precise pathogenesis is unknown, the clinical relevance of this phenomenon is clear. There is a need for histologic confirmation of suspected metastatic mediastinal adenopathy in patients with testicular cancer. We are collecting more cases in other malignancies and will present an update.

P81 Poster Cardiac computed tomography as part of nurse-led assessment in acute medical admissions in the United Kingdom

2011 ◽  
Vol 10 (1_suppl) ◽  
pp. 19-19
Author(s):  
L. Bryan ◽  
C.M. Patterson ◽  
M.K.J. Duncan ◽  
J.R. Collinson ◽  
S.P.G. Padley
Keyword(s):  
Computed Tomography ◽  
United Kingdom ◽  
Cardiac Computed Tomography ◽  
The United Kingdom

Care of Children at a Large Outdoor Music Festival in the United Kingdom

2010 ◽  
Vol 25 (3) ◽  
pp. 223-226 ◽  
Author(s):  
Carl P. McQueen
Keyword(s):  
United Kingdom ◽  
Adult Population ◽  
Medical Attention ◽  
Valuable Insight ◽  
Music Festivals ◽  
Music Festival ◽  
Mass Gatherings ◽  
The United Kingdom ◽  
Special Events ◽  
The Uk

AbstractIntroduction:Limited data exist on the standard of care provided for children at mass gatherings and special events (MGSE). Some studies provide valuable insight into the proportion of pediatric patients that can be expected at various types of MGSEs, but an accurate breakdown of the range of pediatric conditions treated at major events has yet to be produced. Such data are essential for the preparation of MGSEs so that the health and safety of children at such events can be adequately safeguarded. The aim of this study is to examine the care requirements for children at a large, outdoor music festival in the United Kingdom.Methods:A retrospective review of all patient report forms (PRFs) from a large, outdoor music festival held in Leeds (UK) in 2003. Data were extracted from the PRFs using a standardized proforma and analyzed using an Excel computer program.Results:Pediatric cases contributed approximately 15% to the overall workload at the event. Children presented with a range of conditions that varied from those seen in the adult population. Children were more likely than adults to present for medical attention following crush injuries (OR = 2.536; 95% CI = 1.537–4.187); after a collapse/syncopal episode (OR = 2.687; 95% CI = 1.442–5.007); or complaining of nausea (OR = 3.484; 95% CI = 2.089–5.813). Alcohol/drugs were less likely to be involved in the precipitating cause for medical attention in children compared to adults (OR = 0.477; 95% CI = 0.250–0.912). No critical care incidents involving children were encountered during the event.Conclusions:Mass gatherings and special events in the UK, such as outdoor music festivals, can involve a large number of children who access medical care for a different range of conditions compared to adults. The care of children at large, outdoor music events should not be overlooked. Event planning in the UK should include measures to ensure that appropriately trained and equipped medical teams are used at music festivals to safeguard the welfare of children who may attend. Further research into this exciting area is required.

scholarly journals SP4.2.5 Did COVID-19 change the way we treat appendicitis?

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Libor Hurt ◽  
Nicholas Mowbray ◽  
Anna Powell-Chandler ◽  
Nicola Reeves ◽  
Susan Chandler ◽  
...  
Keyword(s):  
Computed Tomography ◽  
United Kingdom ◽  
Acute Appendicitis ◽  
Conservative Approach ◽  
Prospective Audit ◽  
Radiological Findings ◽  
The United Kingdom ◽  
South Wales ◽  
Radiological Data ◽  
Operation Rate

Abstract Intro/aims In repsonse to the COVID-19 pandemic, the United Kingdom (UK) commenced a national lockdown in March 2020. Initial guidance advocated the avoidance of aerosol generating procedures and hence we hypothesised there would be a decrease in the use of surgery to treat acute appendicitis. Methods A prospective audit was undertaken across 4 hospitals in South Wales, UK, during April 2020. Patients over 18 years of age with suspected or confirmed appendicitis were identified and data was collected including their history, radiological findings, management, and re-admission. Comparison was made with theatre and radiological data from April 2018 and 2019. Results A total of 254 patients were treated over the 3-year period; 95 patients in 2018, 95 in 2019 and 64 in 2020. During the lockdown, the use of Computed Tomography (CT) increased from 36.3% to 85.9% (p < 0.001). An antibiotic only approach to treat appendicits rose from 6.2% to 40.6% (p < 0.001). Four patients in the lockdown cohort failed the conservative approach and required an appendicectomy. The overall rate of laparoscopic appendicectomy was reduced from 85.3% to 17.2% (p < 0.001). A malignancy was identified in 3% of cases. Conclusions Whilst less patients presented with acute appendicitis compared to previous years, there was still a significant reduction in the operation rate. The data aligns with the literature confirming the antibiotic-only approach to be safe with a low failure rate. It is essential however that patients are fully consented for this approach including the risk of a missed malignancy.

scholarly journals CRYPTORCHIDISM WITH BILATERAL SYNCHRONOUS TESTICULAR GERM CELL TUMOUR

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Dr. Garima Choudhary ◽  
Dr. Vanita Kumar ◽  
Dr. Sharda Dawan ◽  
Dr. Qadir Fatima ◽  
Dr. Neelu Gupta
Keyword(s):  
Risk Factors ◽  
Germ Cell ◽  
Undescended Testis ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Testicular Tumour ◽  
Testicular Germ Cell Tumour ◽  
Testicular Germ Cell ◽  
Genitourinary System

Cryptorchidism or undescended testis is a very common anomaly of the male genitourinary system. It is one of the established risk factors for testicular tumour. The commonest malignancy noted in cryptorchidism is seminoma testis. The presence of bilateral synchronous testicular tumour in cryptorchidism is very rare.  

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