Mauritian Joint Child Health Project: A Multigenerational Family Study Emerging from a Prospective Birth Cohort Study: Initial Alcohol-related Outcomes in the Offspring Generation

2021 ◽  
pp. 193-232
Author(s):  
Susan E. Luczak ◽  
Shameem Oomur ◽  
Kristina Jackson ◽  
Tashneem Mahoomed

This chapter investigates parental factors in offspring alcohol involvement in the families of the Joint Child Health Project (JCHP), a longitudinal study that has followed a 1969-1970 birth cohort on the east African island nation of Mauritius since 1972. We were particularly interested in whether parent-child gender played a role in these parent-child alcohol relationships. The analytic sample included 1,147 13-24-year-old offspring of the original JCHP birth cohort. Both child-and parent-rated parental drinking norms and behaviors were associated with child alcohol use and binge drinking. Parental predictors of offspring drinking differed for daughters and sons, with daughter alcohol involvement related to both mother and father alcohol-related factors, whereas son alcohol involvement was more associated with paternal factors. These results highlight the value of longitudinal, multi-informant family studies for eludicating how familial factors combine to influence drinking behaviors of younger generations during developmental periods when drinking and high-risk drinking typically emerge.

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1500
Author(s):  
Jabulani R. Ncayiyana ◽  
Leonardo Martinez ◽  
Elizabeth Goddard ◽  
Landon Myer ◽  
Heather J. Zar

Early-life vitamin D deficiency is associated with adverse child health outcomes, but the prevalence of vitamin D deficiency and its correlates in infants remains underexplored, particularly in sub-Saharan Africa. We aimed to investigate the prevalence of vitamin D deficiency and its correlates among young infants in South Africa. This study included 744 infants, aged 6–10 weeks from the Drakenstein Child Health Study, a population-based birth cohort. Infants were categorized into distinct categories based on serum 25(OH)D concentration level including deficient (<50 nmol/L), insufficient (50–74 nmol/L), and sufficient (≥75 nmol/L). Using multivariable Tobit and logistic regression models, we examined the correlates of serum 25(OH)D3 levels. The overall prevalence of vitamin D deficiency was 81% (95% confidence intervals (CI]) 78–83). Multivariable regression analysis showed that serum 25(OH)D3 concentration was independently associated with study site, socioeconomic status, and sex. Birth in winter and breastfeeding were the strongest predictors of lower serum 25(OH)D3 concentration levels. Compared to non-breastfed children, children breastfed were at higher risk of vitamin D deficiency (AOR, 1.96; 95% CI, 1.04–3.67) and breastfeeding for more than one month was associated with greater likelihood of vitamin D deficiency (AOR, 5.40; 95% CI, 2.37–12.32) and lower vitamin D concentrations (−16.22 nmol/L; 95% CI, −21.06, −11.39). Vitamin D deficiency in infants is ubiquitous, under-recognised, and strongly associated with season of birth and breastfeeding in this setting. Nutritional interventions with vitamin D supplementation in national health programs in low- and middle-income countries are urgently needed to improve early-life vitamin D status in infants.


BMJ Open ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. e034513
Author(s):  
Marly A Cardoso ◽  
Alicia Matijasevich ◽  
Maira Barreto Malta ◽  
Barbara Hatzlhoffer Lourenco ◽  
Suely G A Gimeno ◽  
...  

PurposeMaternal and Child Health and Nutrition in Acre, Brazil (MINA-Brazil) is a longitudinal, prospective population-based birth cohort, set-up to understand the effects of early environmental exposures and maternal lifestyle choices on growth and development of the Amazonian children.ParticipantsMother–baby pairs (n=1246) were enrolled at delivery from July 2015 to June 2016 in Cruzeiro do Sul, Acre, Brazil. Mothers of 43.7% of the cohort were recruited in the study during pregnancy from February 2015 to January 2016. Study visits took place during pregnancy, delivery, at 1 month, 6 months, 1 year and 2 years after delivery. In addition to clinical and epidemiological data, samples collected by the MINA-Brazil study include plasma, serum and extracted DNA from blood and faeces, which are stored in a biobank.Findings to dateKey baseline reports found a high prevalence of gestational night blindness (11.5%; 95% CI 9.97% to 13.25%) and maternal anaemia (39.4%; 95% CI 36.84% to 41.95%) at delivery. Antenatal malaria episodes (74.6% ofPlasmodium vivax) were diagnosed in 8.0% of the women and were associated with an average reduction in birth weight z-scores of 0.35 (95% CI 0.14 to 0.57) and in birth length z-scores of 0.31 (95% CI 0.08 to 0.54), compared with malaria-free pregnancies. At 2-year follow-up, data collection strategies combined telephone calls, WhatsApp, social media community and home visits to minimise losses of follow-up (retention rate of 79.5%).Future plansA 5-year follow-up visit is planned in 2021 with similar interviews and biospecimens collection. The findings from this prospective cohort will provide novel insights into the roles of prenatal and postnatal factors in determining early childhood development in an Amazonian population.


BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e017086 ◽  
Author(s):  
Ginden Chen ◽  
Wan-Lin Chiang ◽  
Bih-Ching Shu ◽  
Yue Leon Guo ◽  
Shu-Ti Chiou ◽  
...  

ObjectivesWhether birth by caesarean section (CS) increases the occurrence of neurodevelopmental disorders, asthma or obesity in childhood is controversial. We tried to demonstrate the association between children born by CS and the occurrence of the above three diseases at the age of 5.5 years.MethodsThe database of the Taiwan Birth Cohort Study which was designed to assess the developmental trajectories of 24 200 children born in 2005 was used in this study. Associations between children born by CS and these three diseases were evaluated before and after controlling for gestational age (GA) at birth, children’s characteristics and disease-related predisposing factors.ResultsChildren born by CS had significant increases in neurodevelopmental disorders (20%), asthma (14%) and obesity (18%) compared with children born by vaginal delivery. The association between neurodevelopmental disorders and CS was attenuated after controlling for GA at birth (OR 1.15; 95% CI 0.98 to 1.34). Occurrence of neurodevelopmental disorders steadily declined with increasing GA up to ≤40–42 weeks. CS and childhood asthma were not significantly associated after controlling for parental history of asthma and GA at birth. Obesity in childhood remained significantly associated with CS (OR 1.13; 95% CI 1.04 to 1.24) after controlling for GA and disease-related factors.ConclusionsOur results implied that the association between CS birth and children’s neurodevelopmental disorders was significantly influenced by GA. CS birth was weakly associated with childhood asthma since parental asthma and preterm births are stronger predisposing factors. The association between CS birth and childhood obesity was robust after controlling for disease-related factors.


2014 ◽  
Vol 135 ◽  
pp. 37-44 ◽  
Author(s):  
Susan E. Luczak ◽  
Carol A. Prescott ◽  
Cyril Dalais ◽  
Adrian Raine ◽  
Peter H. Venables ◽  
...  

1991 ◽  
Vol 5 (2) ◽  
pp. 211-233 ◽  
Author(s):  
D. Yach ◽  
N. Cameron ◽  
N. Padayachee ◽  
L. Wagstaff ◽  
L. Richter ◽  
...  

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