Preparation of low-molecular-weight chitosan derivative zinc complexes and their effect on the growth of liver cancer cells in vitro

2009 ◽  
Vol 81 (12) ◽  
pp. 2397-2405 ◽  
Author(s):  
Rong-Min Wang ◽  
Nai-Pu He ◽  
Peng-Fei Song ◽  
Yu-Feng He ◽  
Lan Ding ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Schiff Base ◽  
Light Scattering ◽  
Liver Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Electrostatic Interactions ◽  
Low Molecular Weight ◽  
Liver Cancer Cells

Low-molecular-weight (LMW) chitosan salicylaldehyde Schiff-base and its zinc(II) complexes were synthesized and characterized by Fourier transform-infrared (FT-IR) spectra, transmission electron microscopy (TEM), dynamic light scattering (DLS), gel permeation chromatography-multiangle laser light scattering (GPC-MALLS), and elemental analysis. The results of electrophoretic analysis suggest that the Zn complexes bound to DNA by means of electrostatic interactions and intercalation. The effect of the Zn complexes on the growth of SMMC-7721 liver cancer cells was investigated by sulforhodamine B assay in vitro. The results reveal that the growth of liver cancer cells was inhibited by LMW-chitosan and their Zn complexes. The inhibition rate of the Zn complexes was higher than that of LMW-chitosan ligand. The LMW-chitosan Schiff-base Zn complex exhibited higher anticancer activity than the LMW-chitosan Zn complex. Combining LMW-chitosan with Schiff-base and Zn improved its anticancer activity, which we ascribe to the synergistic effect between the chitosan matrix and the planar construction of the Zn complexes.

Encapsulation of a Ru(η6-p-cymene) complex of the antibacterial drug trimethoprim into a polydiacetylene-phospholipid assembly to enhance its in vitro anticancer and antibacterial activities

2020 ◽  
Vol 44 (46) ◽  
pp. 20047-20059
Author(s):  
Durairaj Gopalakrishnan ◽  
Chezhiyan Sumithaa ◽  
Arumugam Madan Kumar ◽  
Nattamai S. P. Bhuvanesh ◽  
Suvankar Ghorai ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Antibacterial Activities ◽  
Antibacterial Drug ◽  
First Report ◽  
Liver Cancer Cells ◽  
Arene Complex

The first report of a Ru(arene)–liposome nanoaggregate to enhance the in vitro anticancer activity of a Ru–arene complex in liver cancer cells.

In vitro study of doxorubicin-loaded thermo- and pH-tunable carriers for targeted drug delivery to liver cancer cells

2021 ◽  
Vol 104 ◽  
pp. 93-105
Author(s):  
Sikhumbuzo Charles Kunene ◽  
Kuen-Song Lin ◽  
Meng-Tzu Weng ◽  
Maria Janina Carrera Espinoza ◽  
Chun-Ming Wu
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Liver Cancer Cells ◽  
Targeted Drug

scholarly journals Synergistic Interaction between the HDAC Inhibitor, MPT0E028, and Sorafenib in Liver Cancer Cells In Vitro and In Vivo

2014 ◽  
Vol 20 (5) ◽  
pp. 1274-1287 ◽  
Author(s):  
Chun-Han Chen ◽  
Mei-Chuan Chen ◽  
Jing-Chi Wang ◽  
An-Chi Tsai ◽  
Ching-Shih Chen ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Hdac Inhibitor ◽  
Synergistic Interaction ◽  
Liver Cancer Cells

The interaction of bacterial magnetosomes and human liver cancer cells in vitro

2017 ◽  
Vol 427 ◽  
pp. 105-110 ◽  
Author(s):  
Pingping Wang ◽  
Chuanfang Chen ◽  
Changyou Chen ◽  
Yue Li ◽  
Weidong Pan ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells
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