Development of a Highly Sensitive Label-Free Nucleic Acid Biosensor

2012 ◽  
Author(s):  
Bailin Zhang ◽  
Shatha Dallo ◽  
Ralph Peterson ◽  
Syed Hussain ◽  
Tao Weitao ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Label Free ◽  
Highly Sensitive

scholarly journals Ultraspecific and Highly Sensitive Nucleic Acid Detection by Integrating a DNA Catalytic Network with a Label-Free Microcavity

Small ◽  
2014 ◽  
Vol 10 (10) ◽  
pp. 2067-2076 ◽  
Author(s):  
Yuqiang Wu ◽  
David Yu Zhang ◽  
Peng Yin ◽  
Frank Vollmer
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Detection ◽  
Label Free ◽  
Highly Sensitive ◽  
Catalytic Network

scholarly journals Optical Monitoring of the Production Quality of Si-Nanoribbon Chips Intended for the Detection of ASD-Associated Oligonucleotides

Micromachines ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 147
Author(s):  
Kristina A. Malsagova ◽  
Tatyana O. Pleshakova ◽  
Vladimir P. Popov ◽  
Igor N. Kupriyanov ◽  
Rafael A. Galiullin ◽  
...  
Keyword(s):  
Production Quality ◽  
Autism Spectrum ◽  
Covalent Immobilization ◽  
Biological Macromolecules ◽  
Label Free ◽  
Raman Scattering Spectroscopy ◽  
Dna Oligonucleotides ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Gas-phase etching and optical lithography were employed for the fabrication of a silicon nanoribbon chip (Si-NR chip). The quality of the so-fabricated silicon nanoribbons (Si-NRs) was monitored by optical Raman scattering spectroscopy. It was demonstrated that the structures of the Si-NRs were virtually defect-free, meaning they could be used for highly sensitive detection of biological macromolecules. The Si-NR chips were then used for the highly sensitive nanoelectronics detection of DNA oligonucleotides (oDNAs), which represent synthetic analogs of 106a-5p microRNA (miR-106a-5p), associated with the development of autism spectrum disorders in children. The specificity of the analysis was attained by the sensitization of the Si-NR chip sur-face by covalent immobilization of oDNA probes, whose nucleotide sequence was complementary to the known sequence of miR-106a-5p. The use of the Si-NR chip was demonstrated to al-low for the rapid label-free real-time detection of oDNA at ultra-low (~10−17 M) concentrations.

Application strategies of peptide nucleic acids toward electrochemical nucleic acid sensors

The Analyst ◽  
2021 ◽  
Author(s):  
Qingteng Lai ◽  
Wei Chen ◽  
Yanke Zhang ◽  
Zheng-Chun Liu
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Dna Probes ◽  
Highly Sensitive ◽  
Increased Sensitivity ◽  
Acid Sensors

Peptide nucleic acids (PNAs) have attracted tremendous interest in the fabrication of highly sensitive electrochemical nucleic acid biosensor due to their higher stability and increased sensitivity than common DNA probes....

Label-Free Highly Sensitive Hybrid Plasmonic Biosensor for the Detection of DNA Hybridization

2017 ◽  
Vol 35 (22) ◽  
pp. 4851-4858 ◽  
Author(s):  
Mohamed Farhat O. Hameed ◽  
Ahmed Samy Saadeldin ◽  
Essam M. A. Elkaramany ◽  
Salah S. A. Obayya
Keyword(s):  
Dna Hybridization ◽  
Label Free ◽  
Highly Sensitive

Label-free electrochemical detection of prostate-specific antigen based on nucleic acid aptamer

2015 ◽  
Vol 68 ◽  
pp. 49-54 ◽  
Author(s):  
M. Souada ◽  
B. Piro ◽  
S. Reisberg ◽  
G. Anquetin ◽  
V. Noël ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Prostate Specific Antigen ◽  
Electrochemical Detection ◽  
Specific Antigen ◽  
Label Free
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