Highly sensitive and label-free electrochemical biosensor based on gold nanostructures for studying the interaction of prostate cancer gene sequence with epirubicin anti-cancer drug

2021 ◽  
pp. 106668
Author(s):  
Rokhsareh Abedi ◽  
Jahan Bakhsh Raoof ◽  
Ayemeh Bagheri Hashkavayi ◽  
Maryam Asghary
Keyword(s):  
Prostate Cancer ◽  
Gene Sequence ◽  
Electrochemical Biosensor ◽  
Gold Nanostructures ◽  
Cancer Drug ◽  
Cancer Gene ◽  
Label Free ◽  
Highly Sensitive ◽  
Anti Cancer

scholarly journals Optimization of the Electrodeposition of Gold Nanoparticles for the Application of Highly Sensitive, Label-Free Biosensor

Biosensors ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 50 ◽  
Author(s):  
Hao-Chun Chiang ◽  
Yanyan Wang ◽  
Qi Zhang ◽  
Kalle Levon
Keyword(s):  
Gold Nanoparticles ◽  
Signal Amplification ◽  
Electrochemical Biosensor ◽  
Aqueous Electrolyte ◽  
Label Free ◽  
Reduction Step ◽  
Glucose Biosensors ◽  
Highly Sensitive ◽  
Amperometric Glucose Biosensors ◽  
Aunp Surface

A highly sensitive electrochemical biosensor with a signal amplification platform of electrodeposited gold nanoparticle (AuNP) has been developed and characterized. The sizes of the synthesized AuNP were found to be critical for the performance of biosensor in which the sizes were dependent on HAuCl4 and acid concentrations; as well as on scan cycles and scan rates in the gold electro-reduction step. Systematic investigations of the adsorption of proteins with different sizes from aqueous electrolyte solution onto the electrodeposited AuNP surface were performed with a potentiometric method and calibrated by design of experiment (DOE). The resulting amperometric glucose biosensors was demonstrated to have a low detection limit (> 50 μM) and a wide linear range after optimization with AuNP electrodeposition.

Highly sensitive detection of anti-cancer drug based on bimetallic reduced graphene oxide nanocomposite

Chemosphere ◽  
2021 ◽  
pp. 132281
Author(s):  
Bathinapatla Sravani ◽  
S. Kiranmai ◽  
G. Rajasekhar Reddy ◽  
Jong Pil Park ◽  
Y. Veera Manohara Reddy ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Sensitive Detection ◽  
Cancer Drug ◽  
Reduced Graphene ◽  
Highly Sensitive ◽  
Anti Cancer ◽  
Highly Sensitive Detection

scholarly journals An electrochemical biosensor for prostate cancer biomarker detection using graphene oxide-gold nanostructures

2019 ◽  
Vol 19 (3) ◽  
pp. 206-216 ◽  
Author(s):  
Zahra Akbari jonous ◽  
Javad Shabani Shayeh ◽  
Fatemeh Yazdian ◽  
Amir Yadegari ◽  
Mohadeseh Hashemi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Graphene Oxide ◽  
Electrochemical Biosensor ◽  
Cancer Biomarker ◽  
Gold Nanostructures ◽  
Biomarker Detection

scholarly journals Drug Repositioning of the α1-Adrenergic Receptor Antagonist Naftopidil: A Potential New Anti-Cancer Drug?

2020 ◽  
Vol 21 (15) ◽  
pp. 5339
Author(s):  
Romane Florent ◽  
Laurent Poulain ◽  
Monique N'Diaye
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Adrenergic Receptor ◽  
Drug Repositioning ◽  
Failure Process ◽  
Drug Repurposing ◽  
Cancer Drug ◽  
Cancer Management ◽  
Anti Cancer ◽  
Cancer Types

Failure of conventional treatments is often observed in cancer management and this requires the development of alternative therapeutic strategies. However, new drug development is known to be a high-failure process because of the possibility of a lower efficacy than expected for the drug or appearance of non-manageable side effects. Another way to find alternative therapeutic drugs consists in identifying new applications for drugs already approved for a particular disease: a concept named “drug repurposing”. In this context, several studies demonstrated the potential anti-tumour activity exerted by α1-adrenergic receptor antagonists and notably renewed interest for naftopidil as an anti-cancer drug. Naftopidil is used for benign prostatic hyperplasia management in Japan and a retrospective study brought out a reduced incidence of prostate cancer in patients that had been prescribed this drug. Further studies showed that naftopidil exerted anti-proliferative and cytotoxic effects on prostate cancer as well as several other cancer types in vitro, as well as ex vivo and in vivo. Moreover, naftopidil was demonstrated to modulate the expression of Bcl-2 family pro-apoptotic members which could be used to sensitise cancer cells to targeting therapies and to overcome resistance of cancer cells to apoptosis. For most of these anti-cancer effects, the molecular pathway is either not fully deciphered or shown to involve α1-adrenergic receptor-independent pathway, suggesting off target transduction signals. In order to improve its efficacy, naftopidil analogues were designed and shown to be effective in several studies. Thereby, naftopidil appears to display anti-cancer properties on different cancer types and could be considered as a candidate for drug repurposing although its anti-cancerous activities need to be studied more deeply in prospective randomized clinical trials.

Label-free fluorescence imaging of cytochrome c in living systems and anti-cancer drug screening with nitrogen doped carbon quantum dots

Nanoscale ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 5342-5349 ◽  
Author(s):  
Haijuan Zhang ◽  
Baoxin Zhang ◽  
Cuixia Di ◽  
Mohammad Chand Ali ◽  
Jia Chen ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Drug Screening ◽  
Fluorescence Probe ◽  
Carbon Quantum Dots ◽  
Living Systems ◽  
Cancer Drug ◽  
Label Free ◽  
Nitrogen Doped ◽  
Anti Cancer ◽  
Nitrogen Doped Carbon

A label-free fluorescence probe based on N-doped CDs for imaging of Cyt c in living systems and anti-cancer drug screening.

Sign in / Sign up

Export Citation Format

Share Document